[Federal Register Volume 59, Number 203 (Friday, October 21, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-26136]


[[Page Unknown]]

[Federal Register: October 21, 1994]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-88]

 

Availability of Draft Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Public Health Service (PHS), Department of Health and Human Services 
(HHS).

ACTION: Notice of availability.

-----------------------------------------------------------------------

SUMMARY: The Comprehensive Environmental Response, Compensation, and 
Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments 
and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9604(i)(3)] directs 
the Administrator of ATSDR to prepare toxicological profiles of 
priority hazardous substances and to revise and republish each 
toxicological profile as necessary. This notice announces the 
availability of 8 updated drafts and 2 new draft toxicological profiles 
prepared by ATSDR for review and comment.

DATES: To ensure consideration, comments on these draft toxicological 
profiles must be received on or before February 21, 1995. Comments 
received after the close of the public comment period will be 
considered at the discretion of ATSDR based upon what is deemed to be 
in the best interest of the general public.

ADDRESSES: Requests for copies of the draft toxicological profiles or 
comments regarding the draft toxicological profiles should be sent to 
the attention of Ms. Kim Fears, Division of Toxicology, Agency for 
Toxic Substances and Disease Registry, Mailstop E-29, 1600 Clifton 
Road, NE., Atlanta, Georgia 30333.
    Requests for the draft toxicological profiles must be in writing. 
Please specify the profiled hazardous substance(s) you wish to receive. 
ATSDR reserves the right to provide only one copy of each profile 
requested, free of charge. In case of extended distribution delays, 
requestors will be notified.
    Written comments and other data submitted in response to this 
notice and the draft toxicological profiles should bear the docket 
control number ATSDR-88. Send one copy of all comments and three copies 
of all supporting documents to the Division of Toxicology at the above 
address by the end of the comment period. All written comments and 
draft profiles will be available for public inspection at the ATSDR, 
Building 4, Executive Park Drive, Atlanta, Georgia (not a mailing 
address), from 8:00 a.m. until 4:30 p.m., Monday through Friday, except 
for legal holidays.
    Because all public comments regarding ATSDR toxicological profiles 
are available for public inspection, no confidential business 
information should be submitted in response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Kim Fears, Division of Toxicology, 
Agency for Toxic Substances and Disease Registry, Mailstop E-29, 1600 
Clifton Road, NE., Atlanta, Georgia 30333, telephone (404) 639-6304.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental 
Response, Compensation, and Liability Act (CERCLA or Superfund) (42 
U.S.C. 9601 et seq.) by establishing certain responsibilities for the 
ATSDR and the Environmental Protection Agency (EPA) with regard to 
hazardous substances which are most commonly found at facilities on the 
CERCLA National Priorities List (NPL). Among these statutory provisions 
is that the Administrator of ATSDR prepare toxicological profiles for 
substances included on the priority lists of hazardous substances. 
These lists identified the 275 hazardous substances which both Agencies 
determined pose the most significant potential threat to human health. 
The availability of the revised priority list of 275 hazardous 
substances was announced in the Federal Register on February 28, 1994 
(59 FR 9486). For prior versions of the list of substances see Federal 
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 
42067); October 17, 1991 (56 FR 52166); and October 28, 1992 (57 FR 
48801). CERCLA also requires ATSDR to assure the initiation of a 
research program to fill data needs associated with the substances.
    Section 104(i)(3) of CERCLA (42 U.S.C. 9604(i)(3)) outlines the 
content of these profiles. Each profile is required to include an 
examination, summary and interpretation of available toxicological 
information and epidemiologic evaluations. This information and data 
are to be used to ascertain the levels of significant human exposure 
for the substance and the associated health effects. The profiles must 
also include a determination of whether adequate information on the 
health effects of each substance is available or in the process of 
development. When adequate information is not available, ATSDR, in 
cooperation with the National Toxicology Program (NTP), is required to 
assure the initiation of a program of research designed to determine 
these health effects.
    Although key studies for each of the substances were considered 
during the profile development process, this Federal Register notice 
seeks to solicit any additional studies, particularly unpublished data 
and ongoing studies, which will be evaluated for possible addition to 
the profiles now or in the future.
    The following draft toxicological profiles are expected to be 
available to the public on or about October 17, 1994. 

------------------------------------------------------------------------
             Document and hazardous substance                  CAS No.  
------------------------------------------------------------------------
1. Carbon Disulfide (UPDATE)..............................       75-15-0
2. Creosote (UPDATE)......................................     8001-58-9
3. Diazinon...............................................      333-41-5
4. 1,2-Dichloroethene (trans/cis) (UPDATE)................      156-60-5
..........................................................      156-59-2
5. Endrin and Endrin Aldehyde (UPDATE)....................       72-20-8
..........................................................    53494-70-5
6. Hexachlorobenzene (UPDATE).............................      118-74-1
7. Methyl T-Butyl Ether...................................     1634-04-4
8. Selenium (UPDATE)......................................     7782-49-2
9. 1,1,2,2-Tetrachloroethane (UPDATE).....................       79-34-5
10. Toxaphene (UPDATE)....................................    8001-35-2 
------------------------------------------------------------------------

    All profiles issued as ``Drafts for Public Comment'' represent the 
agency's best efforts to provide important toxicological information on 
priority hazardous substances in compliance with the substantive and 
procedural requirements of Section 104(i)(3) of CERCLA, as amended. As 
in the past, we are seeking public comments and additional information 
which may be used to supplement these profiles. ATSDR remains committed 
to providing a public comment period for these documents as a means to 
best serve public health and our clients.

    Dated: October 17, 1994.
Claire V. Broome,
Deputy Administrator, Agency for Toxic Substances and Disease Registry.
[FR Doc. 94-26136 Filed 10-20-94; 8:45 am]
BILLING CODE 4163-70-P