[Federal Register Volume 59, Number 178 (Thursday, September 15, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-22810]


[[Page Unknown]]

[Federal Register: September 15, 1994]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service

 

National Toxicology Program; Availability of Technical Report on 
Toxicology and Carcinogenesis Studies of Barium Chloride Dihydrate

    The HHS' National Toxicology Program announces the availability of 
the NTP Technical Report on the toxicology and carcinogenesis studies 
of barium chloride dihydrate, a white crystalline granule or powder, 
used in pigments, aluminum refining, leather tanning and coloring, the 
manufacture of magnesium metal, ceramics, glass, and paper products, as 
a pesticide, and in medicine as a cardiac stimulant.
    Toxicology and carcinogenicity studies were conducted by 
administering barium chloride dihydrate (99% pure) in drinking water at 
concentrations of 0, 500, 1,250, or 2,500 ppm to groups of 60 F344/N 
rats and B6C3F1 mice of each sex for two years.
    Under the conditions of these 2-year drinking water studies, there 
was no evidence of carcinogenic activity\1\ of barium chloride 
dihydrate in male or female F344/N rats that received 500, 1,250, or 
2,500 ppm. There was no evidence of carcinogenic activity of barium 
chloride dihydrate in male or female B6C3F1, mice that received 
500, 1,250, or 2,500 ppm.
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    \1\The NTP uses five categories of evidence of carcinogenic 
activity observed in each animal study: Two categories for positive 
results (``clear evidence'' and ``some evidence''), one category for 
uncertain findings (``equivocal evidence''), one category for no 
observable effect (``no evidence''), and one category for studies 
that cannot be evaluated because of major flaws (``inadequate 
study'').
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    There were chemical-related increased incidences of nephropathy in 
male and female mice.
    Questions or comments about the Technical Report should be directed 
to Central Data Management at P.O. Box 12233, Research Triangle Park, 
NC 27709 or telephone (919) 541-3419.
    Copies of Toxicology and Carcinogenesis Studies of Barium Chloride 
Dihydrate (CAS No. 10326-27-9) in F344/N Rats and B6C3F1 Mice 
(Drinking Water Studies) (TR-432) are available without charge from 
Central Data Management, NIEHS, MD A0-01, P.O. Box 12233, Research 
Triangle Park, NC 27709; telephone (919) 541-3419.

    Dated: September 8, 1994.
Kenneth Olden,
Director, National Toxicity Program.
[FR Doc. 94-22810 Filed 9-14-94; 8:45 am]
BILLING CODE 4140-01-M