[Federal Register Volume 59, Number 99 (Tuesday, May 24, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-12567]


[[Page Unknown]]

[Federal Register: May 24, 1994]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service

 

National Toxicology Program; National Toxicology Program (NTP) 
Board of Scientific Counselors' Meeting; Review of Draft NTP Technical 
Reports

    Pursuant to Public Law 92-463, notice is hereby given of the next 
meeting of the NTP Board of Scientific Counselors' Technical Reports 
Review Subcommittee on June 21, 1994, in the Conference Center, 
Building 101, South Campus, National Institute of Environmental Health 
Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North 
Carolina. The meeting will begin at 8:30 a.m. and is open to the 
public. The primary agenda topic is the peer review of draft Technical 
Reports of long-term toxicology and carcinogenesis studies from the 
National Toxicology Program. Additionally, there will be a presentation 
titled ``Diet for Rats and Mice in NTP Studies--Recommendations.''
    Tentatively scheduled to be peer reviewed on June 21 are draft 
Technical Reports of five two-year studies and one report of 52-week 
studies, listed alphabetically along with supporting information in the 
attached table. All two-year studies were done using Fischer 344 rats 
and B6C3F1 mice, and the 52-week studies employed three strains of 
mice (B6C3F1, Swiss CD-1, and Sencar). The order of review is 
given in the far right column of the table. Copies of the draft Reports 
may be obtained, as available, from: Central Data Management, MD A0-01, 
P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-3419).
    Persons wanting to make a formal presentation regarding a 
particular Technical Report must notify the Executive Secretary by 
telephone, by FAX, or by mail no later than June 15, 1994, and provide 
a written copy in advance of the meeting so copies can be made and 
distributed to all Subcommittee members and staff and made available at 
the meeting for attendees. Oral presentations should supplement and not 
just repeat the written statement. Presentations should be limited to 
no more than five minutes.
    The program would welcome receiving toxicology and carcinogenesis 
information from completed, ongoing, or planned studies by others, as 
well as current production data, human exposure information, and use 
patterns on any of the chemicals listed in this announcement. Please 
contact Central Data Management at the address given above, and they 
will relay the information to the appropriate staff scientist.
    The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, 
Research Triangle Park, North Carolina 27709 (telephone 919/541-3971; 
FAX 919/541-2260 will furnish a roster of Subcommittee members prior to 
the meeting. Summary minutes subsequent to the meeting will be 
available upon request.

    Dated: May 16, 1994.
Richard A. Griesemer,
Deputy Director, National Toxicology Program.

  Summary Data and Levels of Evidence for Technical Reports Scheduled for Review at the Meeting of the Board of 
                          Scientific Counselors' Technical Reports Review Subcommittee                          
                                               [June 21-22, 1994]                                               
----------------------------------------------------------------------------------------------------------------
                                                                                                          Review
     Chemical CAS no.                TR no.                 Primary uses          Route/exposure levels    order
----------------------------------------------------------------------------------------------------------------
Acetonitrile 75-05-8.....  TR-447...................  Solvent in hydrocarbon    Inhalation (AIR): Rats:        6
                                                       extraction processes.     0, 100, 200, or 400            
                                                       Specialty solvent.        ppm, Mice: 0, 50, 100,         
                                                       Chemical intermediate.    or 200 ppm; 50/group.          
                                                       Separation of fatty                                      
                                                       acids from vegetable                                     
                                                       oils. Pharmaceuticals.                                   
1-Amino-2,4-Dibromo-       TR-383...................  In manufacture of dyes..  Dosed-Feed (FEED): Rats:       3
 Anthraquinone 81-49-2.                                                          0,.2,.5,1.0,2.0, Mice:         
                                                                                 0,1.0,2.0%; 50 per             
                                                                                 group.                         
Benzethonium Chloride 121- TR-493...................  Topical anti-infective    Topical (ETHANOL): Rats        1
 54-0.                                                 (vet) and antiseptic.     & Mice: 0, 0.15, 0.5,          
                                                       Germicide for cleansing   1.5 mg/kg/50/group.            
                                                       food and dairy                                           
                                                       utensils. In                                             
                                                       controlling swimming                                     
                                                       pool algae and dandruff.                                 
tert-Butyl Alcohol 75-65-  TR-436...................  Extraction of drugs.      Dosed-Water (DEIONIZED         4
 0.                                                    Denaturant in ethanol.    WATER): Rats: 0, 0.125,        
                                                       Dehydration agent. In     0.25, 0.5% (Male). 0,          
                                                       manufacture of            0.25, 0.5, 1.0%                
                                                       flotation agents, fruit   (Female). Mice: 0, 0.5,        
                                                       essences, plastics, and   1.0, 2.0% (Male &              
                                                       perfumes. Solvent.        Female)/50 per group.          
                                                       Chemical intermediate.                                   
                                                       Additive in unleaded                                     
                                                       gasoline.                                                
INIT/PROM Comparative      TR-441...................  Tumor initiator and       Topical (ACETONE): Mice        5
 Mouse Study (DMBA/TPA/                                promoter.                 only: DMBA/ACETONE (50,        
 BPO/MNNG).                                                                      25, 2.5 ug), DMBA 2.5,         
                                                                                 TPA 5 ug, BPO 20 mg,           
                                                                                 DMBA/TPA (2.5,25,50 ug/        
                                                                                 5 ug), DMBA/BPO (2.5,          
                                                                                 25 ug/20 mg) and MNNG/         
                                                                                 ACETONE (1000, 500, 100        
                                                                                 ug), MNNG 100 ug, TPA 5        
                                                                                 ug, BPO 20 mg, MNNG/BPO        
                                                                                 (100, 500, 1000 ug/20          
                                                                                 mg), MNNG/TPA (100,            
                                                                                 1000 ug/5 ug).                 
                           .........................  ........................  Topical (ACETONE): DMBA/        
                                                                                 ACETONE (25, 2.5, .25          
                                                                                 ug), DMBA 2.5, TPA 5           
                                                                                 ug, BPO 20 mg, DMBA/TPA        
                                                                                 (.25,2.5,25/5 ug), DMBA/       
                                                                                 BPO (2.5, 25 ug/20 mg)         
                                                                                 and MNNG/ACETONE (1000,        
                                                                                 500, 100 ug), MNNG 100         
                                                                                 ug, TPA 5 ug, HPO 20           
                                                                                 mg, MNNG/BPO (100, 500,        
                                                                                 1000 ug/20 mg), MNNG/          
                                                                                 TPA (1000, 1000 ug/5           
                                                                                 ug).                           
                           .........................  ........................  Topical (ACETONE): DMBA/        
                                                                                 ACETONE (25,2.5,.25            
                                                                                 ug): DMBA 2.5: TPA 1           
                                                                                 ug: BPO 20 mg: DMBA/TPA        
                                                                                 (.25,2.5,25/1 ug): DMBA/       
                                                                                 BPO (2.5, 25ug/20 mg)          
                                                                                 and MNNG/ACETONE (1000,        
                                                                                 500, 100 ug): MNNG 100         
                                                                                 ug: TPA 5 ug: BPO 20           
                                                                                 mg: MNNG/BPO (100, 500,        
                                                                                 1000 ug/20 mg).                
1-Trans-Delta-9-           TR-446...................  Topical use in            GAVAGE (CORN OIL) Rats:        2
 Tetrahydrocannabinol                                  hypertensive glaucomas.   0, 12.5, 25, or 50;            
 1972-08-3.                                            Active constituent of     Mice: 0, 125,250, or           
                                                       marijuana.                500 mg/kg/50/group.            
----------------------------------------------------------------------------------------------------------------

[FR Doc. 94-12567 Filed 5-23-94; 8:45 am]
BILLING CODE 4140-01-M