[Federal Register Volume 59, Number 93 (Monday, May 16, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-11867]


[[Page Unknown]]

[Federal Register: May 16, 1994]


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DEPARTMENT OF ENERGY
Office of Energy Research

 

Energy Research Financial Assistance Program Notice 94-17; 
Medical Applications Program

AGENCY: U.S. Department of Energy (DOE).

ACTION: Notice inviting grant applications.

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SUMMARY: The Office of Health and Environmental Research (OHER) of the 
Office of Energy Research (ER), U.S. Department of Energy, announces 
its interest in receiving applications to support one specific research 
area, Receptor-Targeted Cancer Imaging and Therapy with Genetically 
Modified Radiolabeled Probes, within the Medical Applications Program. 
The research applications should address the use of antibody-based 
molecular strategies to develop new radiolabeled molecules which will 
significantly advance the current state of tumor imaging and therapy 
for potential human use. Appropriate consideration should be given to 
receptor mediated localization and stability of the administered 
molecular form in vivo, its rate of clearance, selective delivery to 
the target in high yield with target-binding affinity, and specificity 
and selectivity for effective imaging and killing of cancer 
micrometastases. A well integrated multi-disciplinary team effort 
combining the areas of radiopharmaceutical chemistry, molecular 
immunology, and oncologic nuclear medicine to achieve the projected 
goals will be important.

DATES: Formal applications submitted in response to this Notice must be 
received 4:30 p.m., EDT, September 15, 1994, to be accepted for a merit 
review in November 1994, and to permit timely consideration for award 
in Fiscal Year 1995.

ADDRESSES: Formal applications referencing Program Notice 94-17 should 
be forwarded to: U.S. Department of Energy, Office of Energy Research, 
Acquisition and Assistance Management Division, ER-64 (GTN), 
Washington, DC 20585, Attn: Program Notice 94-17. The following address 
must be used when submitting applications by U.S. Postal Service 
Express Mail, any commercial mail delivery service, or when hand 
carried by the applicant: U.S. Department of Energy, Office of Energy 
Research, Acquisition and Assistance Management Division, ER-64, 19901 
Germantown Road, Germantown, Maryland 20874.

FOR FURTHER INFORMATION CONTACT: Dr. Prem C. Srivastava, Office of 
Health and Environmental Research, ER-73, U.S. Department of Energy, 
GTN, Washington, D.C. 20585, telephone: (301) 903-4071.

SUPPLEMENTARY INFORMATION: Potential applicants are strongly encouraged 
to submit a brief preapplication in accordance with 10 CFR 600.10 
(d)(2), which consists of two or three pages of narrative describing 
the research project objectives and methods of accomplishment. These 
will be reviewed relative to the scope and research objectives of the 
Medical Applications Program. Preapplications referencing Program 
Notice 94-17 should be received by June 15, 1994, and sent to Dr. Prem 
C. Srivastava, Office of Health and Environmental Research, ER-73, 
Department of Energy, GTN, Washington, DC 20585, FAX: (301) 903-0567. 
Telephone and FAX numbers are required to be part of the 
preapplication. A response to the preapplications discussing the 
program relevance of a formal application will be communicated by July 
15, 1994.
    It is anticipated that approximately $3 million will be available 
for grant awards during FY 1995 contingent upon availability of 
appropriated funds. Previous awards have ranged from $100,000 per year 
up to $400,000 per year with terms lasting up to 3 years. Similar award 
sizes are anticipated for new grants. Funding of multiple year new 
grant awards is expected, and is also contingent upon availability of 
funds.
    Information about development and submission of applications, 
eligibility limitations, evaluation and selection process, and other 
policies and procedures may be found in the Application Guide for the 
Office of Energy Research Financial Assistance Program and 10 CFR part 
605. The Application Guide is available from the Office of Health and 
Environmental Research, ER-73, U.S. Department of Energy, (GTN), 
Washington, DC 20585. Telephone requests may be made by calling (301) 
903-5349.

    The Catalog of Federal Domestic Assistance Number of this 
program is 81.049.
D.D. Mayhew,
Director, Office of Management, Office of Energy Research
[FR Doc. 94-11867 Filed 5-13-94; 8:45 am]
BILLING CODE 6450-01-P