[Federal Register Volume 59, Number 89 (Tuesday, May 10, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-11160]
[[Page Unknown]]
[Federal Register: May 10, 1994]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program; Fiscal Year 1992 Annual Report
The National Toxicology Program (NTP) announces the availability of
the NTP Annual Plan for Fiscal Year 1992, solicits comments on it, and
urges all interested persons to propose chemicals for possible
toxicological evaluation. In the interest of accuracy due to the
lateness of publication, the FY 1992 edition has been titled the NTP
Annual Report.
The fourteenth edition consists of two parts. First, the NTP Annual
Report for Fiscal Year 1992 describes FY 1992 NTP plans in research,
applied studies, methods development and validation efforts, as well as
resources and FY 1991 program accomplishments. Second, the Review of
Current DHHS, DOE, and EPA Research Related to Toxicology lists
chemicals being studied by the various DHHS agencies, the Department of
Energy, and the Environmental Protection Agency, and describes
toxicology research and toxicology methods currently being developed by
these agencies.
Background
The National Toxicology Program (NTP) was established within the
Public Health Service of the Department of Health and Human Services
(DHHS) in November 1978. The continuing broad goals of the NTP are to
coordinate and strengthen DHHS basic and applied toxicology research
and methods development and validation, and to provide toxicological
information for use by health research and regulatory agencies and
others in protecting the public health. Overall objectives are to:
Broaden the spectrum of toxicological information obtained
on selected chemicals;
Increase the numbers of chemicals studied, within funding
limits;
Develop and validate assays and protocols responsive to
regulatory needs;
Communicate Program plans and results to governmental
agencies, the medical and scientific communities, and the public.
The NTP coordinates selected toxicology activities of the National
Institute of Environmental Health Sciences, National Institutes of
Health; the National Center for Toxicological Research, Food and Drug
Administration; and the National Institute for Occupational Safety and
Health, Centers for Disease Control and Prevention.
Primary program oversight is provided by the NTP Executive
Committee, which links DHHS health research institutes and centers with
Federal health regulatory agencies to ensure that the basic and applied
toxicology research and development activities are responsive to
regulatory and public health needs. Agencies represented on the
Executive Committee are:
Agency for Toxic Substances and Disease Registry
Consumer Product Safety Commission
Environmental Protection Agency
Food and Drug Administration
National Cancer Institute
National Institute for Occupational Safety and Health
National Institute of Environmental Health Sciences
National Institutes of Health
Occupational Safety and Health Administration
The NTP Board of Scientific Counselors provides scientific
oversight, advising the NTP Director and the NTP Executive Committee on
scientific content and evaluating the scientific merit and overall
quality of NTP science. The members (listed in the 1992 Annual Report)
are appointed by the Secretary, DHHS. For the purposes of the Program,
the NTP Director reports to the Assistant Secretary for Health.
Scientific activities are divided into four major program areas:
carcinogenesis; cellular and genetic toxicology; reproductive and
developmental toxicology; and toxicologic characterization. The latter
area covers activities in cardiac, immunologic, neurobehavioral, and
respiratory toxicologies, and includes programs in chemical
disposition, toxicities of AIDS therapeutics, and toxicity of Superfund
chemicals. Program and project leaders, along with addresses and
telephone numbers, are identified in the 1992 Annual Report.
The chemical nomination and selection process is integral to the
effective long-term operation of the NTP with respect to toxicological
studies of chemicals using modern techniques and to the development and
validation of new assay methods. Thus, the NTP welcomes nominations of
chemicals for study from everyone. At a minimum, the nominator should
give the name of the chemical or substance, the rationale for the
nomination, and recommend the type study(s) to be considered. In
addition, it is desirable, but not essential, to supplement each
nomination with the following information, if known:
I. Chemical and physical properties.
II. Production, use, occurrence, and analysis data.
III. Toxicology information.
IV. Chemical disposition and structure-activity relationships.
V. Planned or ongoing or recently completed toxicological and
environmental studies.
To receive the NTP Annual Report for Fiscal Year 1992, and the FY
1992 Review of Current DHHS, DOE, and EPA Research Related to
Toxicology, please write or telephone the NTP Central Data Management,
P.O. Box 12233, MD A0-01, Research Triangle Park, N.C. 27709,
(telephone 919/541-3419).
Comments on the FY 1992 NTP Annual Report are requested and
welcome. These should be addressed to Dr. Larry Hart, National
Toxicology Program, P.O. Box 12233, Research Triangle Park, NC 27709,
(telephone 919/541-3971).
Dated: May 4, 1994.
Richard Griesemer,
Deputy Director, National Toxicology Program.
[FR Doc. 94-11160 Filed 5-9-94; 8:45 am]
BILLING CODE 4140-01-P