[Federal Register Volume 59, Number 89 (Tuesday, May 10, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-11160]


[[Page Unknown]]

[Federal Register: May 10, 1994]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service

 

National Toxicology Program; Fiscal Year 1992 Annual Report

    The National Toxicology Program (NTP) announces the availability of 
the NTP Annual Plan for Fiscal Year 1992, solicits comments on it, and 
urges all interested persons to propose chemicals for possible 
toxicological evaluation. In the interest of accuracy due to the 
lateness of publication, the FY 1992 edition has been titled the NTP 
Annual Report.
    The fourteenth edition consists of two parts. First, the NTP Annual 
Report for Fiscal Year 1992 describes FY 1992 NTP plans in research, 
applied studies, methods development and validation efforts, as well as 
resources and FY 1991 program accomplishments. Second, the Review of 
Current DHHS, DOE, and EPA Research Related to Toxicology lists 
chemicals being studied by the various DHHS agencies, the Department of 
Energy, and the Environmental Protection Agency, and describes 
toxicology research and toxicology methods currently being developed by 
these agencies.

Background

    The National Toxicology Program (NTP) was established within the 
Public Health Service of the Department of Health and Human Services 
(DHHS) in November 1978. The continuing broad goals of the NTP are to 
coordinate and strengthen DHHS basic and applied toxicology research 
and methods development and validation, and to provide toxicological 
information for use by health research and regulatory agencies and 
others in protecting the public health. Overall objectives are to:
     Broaden the spectrum of toxicological information obtained 
on selected chemicals;
     Increase the numbers of chemicals studied, within funding 
limits;
     Develop and validate assays and protocols responsive to 
regulatory needs;
     Communicate Program plans and results to governmental 
agencies, the medical and scientific communities, and the public.
    The NTP coordinates selected toxicology activities of the National 
Institute of Environmental Health Sciences, National Institutes of 
Health; the National Center for Toxicological Research, Food and Drug 
Administration; and the National Institute for Occupational Safety and 
Health, Centers for Disease Control and Prevention.
    Primary program oversight is provided by the NTP Executive 
Committee, which links DHHS health research institutes and centers with 
Federal health regulatory agencies to ensure that the basic and applied 
toxicology research and development activities are responsive to 
regulatory and public health needs. Agencies represented on the 
Executive Committee are:
     Agency for Toxic Substances and Disease Registry
     Consumer Product Safety Commission
     Environmental Protection Agency
     Food and Drug Administration
     National Cancer Institute
     National Institute for Occupational Safety and Health
     National Institute of Environmental Health Sciences
     National Institutes of Health
     Occupational Safety and Health Administration
    The NTP Board of Scientific Counselors provides scientific 
oversight, advising the NTP Director and the NTP Executive Committee on 
scientific content and evaluating the scientific merit and overall 
quality of NTP science. The members (listed in the 1992 Annual Report) 
are appointed by the Secretary, DHHS. For the purposes of the Program, 
the NTP Director reports to the Assistant Secretary for Health.
    Scientific activities are divided into four major program areas: 
carcinogenesis; cellular and genetic toxicology; reproductive and 
developmental toxicology; and toxicologic characterization. The latter 
area covers activities in cardiac, immunologic, neurobehavioral, and 
respiratory toxicologies, and includes programs in chemical 
disposition, toxicities of AIDS therapeutics, and toxicity of Superfund 
chemicals. Program and project leaders, along with addresses and 
telephone numbers, are identified in the 1992 Annual Report.
    The chemical nomination and selection process is integral to the 
effective long-term operation of the NTP with respect to toxicological 
studies of chemicals using modern techniques and to the development and 
validation of new assay methods. Thus, the NTP welcomes nominations of 
chemicals for study from everyone. At a minimum, the nominator should 
give the name of the chemical or substance, the rationale for the 
nomination, and recommend the type study(s) to be considered. In 
addition, it is desirable, but not essential, to supplement each 
nomination with the following information, if known:
    I. Chemical and physical properties.
    II. Production, use, occurrence, and analysis data.
    III. Toxicology information.
    IV. Chemical disposition and structure-activity relationships.
    V. Planned or ongoing or recently completed toxicological and 
environmental studies.
    To receive the NTP Annual Report for Fiscal Year 1992, and the FY 
1992 Review of Current DHHS, DOE, and EPA Research Related to 
Toxicology, please write or telephone the NTP Central Data Management, 
P.O. Box 12233, MD A0-01, Research Triangle Park, N.C. 27709, 
(telephone 919/541-3419).
    Comments on the FY 1992 NTP Annual Report are requested and 
welcome. These should be addressed to Dr. Larry Hart, National 
Toxicology Program, P.O. Box 12233, Research Triangle Park, NC 27709, 
(telephone 919/541-3971).

    Dated: May 4, 1994.
Richard Griesemer,
Deputy Director, National Toxicology Program.
[FR Doc. 94-11160 Filed 5-9-94; 8:45 am]
BILLING CODE 4140-01-P