[Federal Register Volume 59, Number 47 (Thursday, March 10, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-5493]


[[Page Unknown]]

[Federal Register: March 10, 1994]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES
 

National Toxicology Program (NTP) Board of Scientific Counselors' 
Meetings; Announcement of NTP Draft Technical Reports Projected for 
Public Review From June 1994 Through Fall 1995

    To earlier inform the public and allow interested parties to 
comment or obtain information on long-term toxicology and 
carcinogenesis studies prior to public peer review, the National 
Toxicology Program (NTP) again publishes in the Federal Register a 
current listing of draft Technical Reports projected for evaluation by 
the NTP Board of Scientific Counselors' Technical Reports Review 
Subcommittee during their next four meetings from June 1994 through the 
fall of 1995. We plan to continue updating the listing with 
announcements in the Federal Register once or twice a year. The next 
meeting dates are June 21-22, 1994 and November 29-30, 1994. Specific 
dates for 1995 meetings will be established at a later time.
    The attached table 1 lists draft Technical Reports for long-term 
studies on chemicals within known or approximate dates of reviews and 
includes Chemical Abstracts Service (CAS) registry numbers, primary 
use, route of administration, species, exposure levels, and NTP report 
numbers (if assigned).
    Technical Reports of short-time toxicity studies are currently 
reviewed by mail; however, when necessary may be reviewed in open 
meetings. The attached Table 2 lists the draft Technical Reports of 
short-term toxicity studies tentatively projected for review by mail 
during 1994 and also includes Chemical Abstracts Service (CAS) registry 
numbers, primary use, route of administration, species, exposure 
levels, and NTP report numbers (if assigned).
    Those interested in having more information about any of the 
studies listed in this announcement, should contact Central Data 
Management as early as possible by telephone or by mail to: MD-A0-01, 
NIEHS, P.O. Box 12233, Research Triangle Park (RTP), North Carolina 
27709 (919-541-3419). The program would welcome receiving toxicology 
and carcinogenesis data from completed, ongoing or planned studies by 
others as well as current production data, human exposure information, 
and use and use patterns.
    The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, 
Research Triangle Park, North Carolina 27709, telephone 919/541-3971, 
will furnish final agendas and other program information prior to a 
meeting, and summary minutes subsequent to a meeting.


    Attachments.

    Dated: March 3, 1994.
Richard Griesemer,
Deputy Director, National Toxicology Program.

     Table 1.--Long-Term Studies Tentatively Scheduled for Public Peer Review by the NTP Board of Scientific    
             Counselors' Technical Reports Review Subcommittee From June 21, 1994, Through Fall 1995            
----------------------------------------------------------------------------------------------------------------
                                                                                                          NTP TR
       Chemical name/Cas No.             Use        Route    Species            Exposure levels             No. 
----------------------------------------------------------------------------------------------------------------
                        Chemicals Tentatively Scheduled for Peer Review June 21-22, 1994                        
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Acetonitrile, 75-05-8..............  Solv......  Inhal.....  Rm.....  R:0, 100, 200, or 400 PPM M: 0,        447
                                                                       50, 100, or 200 PPM; 50/group.           
1-Amino-2,4-dibromoanthraquinone,    Dye.......  Feed......  Rm.....  R: 0, .2, .5, 1.0, 2.0, M: 0, 1.0,     383
 81-49-2.                                                              2.0 %/50/per group.                      
Benzethonium chloride, 121-54-0....  Germ......  Sp........  Rm.....  R&M: 0, 0.15, 0.5, 1.5 MG/KG/50/       438
                                                                       group.                                   
Tert-butyl alcohol, 75-65-0........  Phar......  Water.....  Rm.....  R: 0, 0.125, 0.25, 0.5% (M). 0,        436
                                                                       0.25, 0.5, 1.0% (F). M: 0, 0.5,          
                                                                       1.0, 2.0% (M&F)/50 per group.            
Init/prom comparative mouse study    Phar......  SP........  Mm.....  DMBA/Acetone (50, 25, 2.5UG), DMBA        
 (DMBA/TPA/BPO/MNNG) init/prom.                                        2.5, TPA 5UG, BPO 20MG, DMBA/TPA         
                                                                       (2.5, 25, 50UG/5UG), DMBA/BPO            
                                                                       (2.5, 25UG/20MG) and MNNG/Acetone        
                                                                       (1000, 500, 100UG), MNNG 100UG,          
                                                                       TPA, 5UG, BPO 20MG, MNNG/BPO             
                                                                       (100, 500, 1000UG/20MG), MNNG/TPA        
                                                                       (100, 1000UG/5UG).                       
Init/prom comparative mouse study    Phar......  Sp........  Mm.....  DMBA/Acetone (25, 2.5, 25UG), DMBA     441
 (DMBA/TPA/BPO/MNNG) imit/prom.                                        2.5, TPA 5 UG, BPO 20MG, DMBA/TPA        
                                                                       (.25, 2.5, 25/5UG), DMBA/BPO             
                                                                       (2.5, 25UG/20MG) and MNNG/Acetone        
                                                                       (1000, 500, 100UG), MNNG 100UG,          
                                                                       TPA 5UG, BPO 20MG, MNNG/BPO (100,        
                                                                       500, 1000UG/20MG), MNNG/TPA              
                                                                       (1000, 1000UG/5UG).                      
Init/prom comparative mouse study    Phar......  Sp........  Mm.....  DMBA/Acetone (25, 2.5, 25UG), DMBA     441
 (DMBA/TPA/BPO/MNNG) init/prom.                                        2.5, TPA 5UG, BPO 20MG, DMBA/TPA         
                                                                       (.25, 2.5, 25/5UG), DMBA/BPO             
                                                                       (2.5, 25UG/20MG) and MNNG/Acetone        
                                                                       (1000, 500, 100UG), MNNG 100UG,          
                                                                       TPA 5UG, BPO 20MG, MNNG/BPO (100,        
                                                                       500, 1000UG/20MG), MNNG/TPA              
                                                                       (1000, 1000UG/5UG)..                     
Init/prom comparative mouse study    Phar......  Sp........  Mm.....  DMBA/Acetone (25, 2.5, .25UG):         441
 (DMBA/TPA/BPO/MNNG) init/prom.                                        DMBA 2.5:TPA 1UG:BPO 20MG: DMBA/         
                                                                       TPA (.25, 2.5, 25/1UG): DMBA/BPO         
                                                                       (2.5, 25UG/20MG) and MNNG/Acetone        
                                                                       (1000, 500, 100UG): MNNG                 
                                                                       100UG:TPA 5UG:BPO 20MG: MNNG/BPO         
                                                                       (100, 500, 1000 UG/20MG).                
1-trans-delta-9-tetrahydro-          Phar......  Gav.......  Rm.....  R: 0, 12.5, 25, or 50; M: 0, 125,         
 cannabinol, 1972-08-3.                                                250, or 500 MG/KG; 50/group.             
----------------------------------------------------------------------------------------------------------------
                                                                                                                
                      Chemicals Tentatively Scheduled for Peer Review November 29-30, 1994                      
----------------------------------------------------------------------------------------------------------------
                                                                                                                
2,2-Bis(Bromomethyl)-1,3-            Flam......  Feed......  Rm.....  R: 0, 2500, 5000, or 10000 PPM; 70/       
 Propanediol, 3296-90-0.                                               group M: 0, 312, 625, or 1250            
                                                                       PPM; 60/group.                           
Isobutyl nitrite, 542-56-3.........  Intr......  Inhal.....  Rm.....  R&M: 0, 37, 75, or 150 PPM........        
Nickel (II) oxide, 1313-99-1.......  Intr......  Inhal.....  Rm.....  R: 0, .62, 1.25, or 2.5 M: 0,             
                                                                       1.25, 2.5, or 5.0 MG/M3; 50/group.       
Nickel sulfate hexahydrate, 10101-   Intr......  Inhal.....  Rm.....  R: 0, 0.125, 0.25, or 0.5 M: 0,           
 97-0.                                                                 .25, .5, or 1.0 MG/M3; 50/group.         
Nickel subsulfide, 12035-72-2......  Envh......  Inhal.....  Rm.....  R: 0, 0.075, or 0.15 M: 0, 0.6, or        
                                                                       1.2 MG/M3; 50/group.                     
Triethanolamine, 102-71-6..........  Dtrg......  Sp........  Rmm....  MR: 0, 32, 63, or 125; FR: 0, 63,         
                                                                       125, or 250; MM: 0, 200, 630, or         
                                                                       2000; FM: 0, 100, 300, or 1000 MG/       
                                                                       KG; 60/group.                            
----------------------------------------------------------------------------------------------------------------
                           Chemicals Tentatively Scheduled for Peer Review Summer 1995                          
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Butyl benzyl phthalate, 85-68-7....  Plas......  Feed......  Rr.....  MR: 0, .3%, .6%, or 1.2%; 60/group        
                                                                       FR: 0, .6%, 1.2%, or 2.4%; 60/           
                                                                       group.                                   
T-butylhydroquinone, 1948-33-0.....  Food......  Feed......  Rmr....  R&M: 0, 0.125, 0.25, or 0.5% in           
                                                                       feed; 70 rats, 60 mice.                  
Codeine, 76-57-3...................  Phar......  Feed......  Rm.....  R: 0, 400, 800, or 1600 M: 0, 750,        
                                                                       1500, or 3000 PPM; 60/group.             
1,2-dihydro-2,2,4-                   Rubr......  Sp........  Rmm....  Rats: 0, 60, or 100 MG/KG, Mice:          
 trimethylquinoline (monomer), 147-                                    0, 6, or 10 MG/KG (core).                
 47-7.                                                                                                          
1,2-dihydro-2,2,4-                   Rubr......  Sp........  Rm.....  Rats: 0, 36, 60, or 100 MG/KG,            
 trimethylquinoline (monomer), 148-                                    Mice: 0, 3.6, 6.0, or 10.0 MG/KG.        
 47-7.                                                                                                          
Salicylazosulfapyridine, 599-79-1..  Phar......  Gav.......  Rm.....  R: 84, 168, or 337.5 MG/KG; 70/           
                                                                       group M: 675, 1350, or 2700 MG/          
                                                                       KG; 60/group.                            
Scopolamine hydrobromide             Phar......  Gav.......  Rmm....  R&M: 0, 1, 5, or 25 MG/KG; 70/            
 trihydrate, 6533-68-2.                                                group diet restriction, Mice: 0          
                                                                       or .25 MG/KG; 70/group.                  
----------------------------------------------------------------------------------------------------------------
                            Chemicals Tentatively Scheduled for Peer Review Fall 1995                           
----------------------------------------------------------------------------------------------------------------
                                                                                                                
D & C yellow No. 11, 8003-22-3.....  Dye.......  Feed......  R......  Rats: 0, 0.05, 0.17, or 0.5%; 60/         
                                                                       group.                                   
ethylbenzene, 100-41-4.............  Rubr......  Inhal.....  Rm.....  R&M: 0, 75, 250, or 750 PPM (50/          
                                                                       sex/species/group).                      
Molybdenum trioxide, 1313-27-5.....  Metl......  Inhal.....  Rm.....  R&M: 10, 30, or 100 MG/M3; 50/sex/        
                                                                       species/group.                           
Nitromethane, 75-52-5..............  Fuel......  Inhal.....  Rm.....  R: 0, 94, 188, or 375 PPM; 50/            
                                                                       group M: 0, 188, 375, or 750 PPM;        
                                                                       50/group.                                
Tetrafluoroethylene, 116-14-3, PPM:  Food......  Inhal.....  Rm.....  Mice & FR: 0, 312, 625, or 1250           
 50/group.                                                             MR: 0, 156, 312, or 625.                 
----------------------------------------------------------------------------------------------------------------

Abbreviations Used in the Report

Use: Primary Use Category:
Comt  Contaminates and/or Impurities
Cosm  Cosmetics, Perfumes, Fragrances, Hair Preparations, Skin 
Lotions
Dtrg  Detergents and Cleansers
Dye  As or in Dyes, Inks, and Pigments
Elec  In Electrical and/or Dielectric Systems or Products
Envh  Environmental (Air/Water) Pollutants
Flam  Flame Retardants
Food  Food, Beverages, or Additives
Fuel  As or in Fuel or Oil Products
Germ  Germicides, Disinfectants, Antiseptics
Herb  Herbicide(s)
Ind  Industrial Uses
Intr  Chemical Intermediate or Catalyst
Labc  Unspecified Chemical Uses not Fitting in Solv, Intr, or Reag 
categories
Metl  Metals or in Metal Products
Papr  As or in Paper or Paper Products
Pest  Pesticides, General or Unclassified
Phar  Pharmaceuticals or Intermediates
Plas  As or in Plastics
Pnt  Paint Ingredient
Rubr  Rubber Chemical
Solv  Vehicles and Solvents
Texl  In Manufacture of Textiles
Route  Route of Administration:
Feed  Dosed-Feed
Gav  Gavage
Inhal  Inhalation
IP/IJ  Intraperitoneal Injection
Ivag  Intravaginal
Micro  Microencapsulation in Feed
SC&GV  Subcutaneous Inj. + Gavage
SP  Topical
Water  Dosed-Water
Spec  Species:
R=Rats
M=Mice

    Table 2.--Short-Term Toxicity Studies Schedule for Peer Review by the NTP Board of Scientific Counselors'   
                                Technical Reports Review Subcommittee during 1994                               
----------------------------------------------------------------------------------------------------------------
                                                                                                            NTP 
       Chemical name/CAS No.            Use        Route     Species            Exposure levels              TR 
                                                                                                            No. 
----------------------------------------------------------------------------------------------------------------
                       Short-Term Toxicity Studies Scheduled for Peer Review January 1994                       
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Beta-bromo-beta-nitrostyrene, 7166-  Pest......  Gav.......  Rm.....  R&M 0, 0.037, 0.075, 0.3, 0.15, 0-      40
 19-0.                                                                 .6 G/KG; 10/group.                       
----------------------------------------------------------------------------------------------------------------
                      Short-Term Toxicity Studies Scheduled for Peer Review February 1994                       
----------------------------------------------------------------------------------------------------------------
                                                                                                                
1,3-diphenylguanidine 102-06-7.....  Rubr......  Feed......  Rm.....  R&M: 250, 500, 750, 1500, 3000 PPM/     42
                                                                       10 Per Group.                            
1-nitropyrene 5522-43-0............  Labc......  Inhal.....  R......  R: 0, 0.5, 2.0, 8.0, 20.0, OR 50.0      34
                                                                       MG/M3 12/S/group (CORE); 5/S/group       
                                                                       for lung burden.                         
----------------------------------------------------------------------------------------------------------------
                        Short-Term Toxicity Studies Scheduled for Peer Review April 1994                        
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Dibutyl phthalate 84-74-2..........  Plas......  Feed......  Rm.....  In utero with F344 Rats; see 30         30
                                                                       C62022B.                                 
Dibutyl phthalate 84-74-2..........  Plas......  Feed......  Rm.....  R: 0, 2500, 5000, 10000, 20000, OR      30
                                                                       40000 Ppm R: 0, 1250, 2500, 5000,        
                                                                       10000, 20000 PPM (10/S/S).               
Methapyrilene hydrochloride 135-23-  Phar......  Feed......  R......  Male rats: 0, 50, 100, 250, 1000        46
 9.                                                                    PPM; 40/group.                           
----------------------------------------------------------------------------------------------------------------
                         Short-Term Toxicity Studies Scheduled for Peer Review May 1994                         
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Cyclohexanone oxime 100-64-1.......  Plas......  Water.....  M......  0, 625, 1250, 2500, 5000, OR 50         50
                                                                       10000 PPM; 10/group.                     
Lead ores leadores.................  Metl......  Feed......  R......  Ores: Males rats, 30/Group; lead        48
                                                                       sulfide used as standard: male and       
                                                                       female 30/Group; 10 add'l males          
                                                                       treated 180 days (PB sulfide) 0,         
                                                                       10, 30, & 100 PPM; particle size         
                                                                       <38 microns; 30, 60, 90-day              
                                                                       sacrifice.                               
Lead sulfide 1314-87-0.............  Pnt.......  Feed......  R......  Rats: male and female 0, 10, 30,        48
                                                                       100 PPM, 10/Group 30, 60, 90, 180        
                                                                       day sac.                                 
Methylene blue trihydrate, 7220-79-  Dye.......  Gav.......  Rm.....  R&M: 0, 0.125, 0.25, 0.5, 1.0, 2.0      51
 3.                                                                    GM/KG Body wt. R: 20/Group/Sex; M:       
                                                                       10/group/sex.                            
Methyl ethyl ketoxime, 96-29-7.....  Pnt.......  Water.....  Rm.....  R&M: 0, 625, 1250, 2500, 5000, OR         
                                                                       10000 PPM; 10/group.                     
                                                                                                                
----------------------------------------------------------------------------------------------------------------
                        Short-Term Toxicity Studies Scheduled for Peer Review June 1994                         
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Class Study of Halogenated Ethanes:                                                                             
  1,2-pitchloro-1,1-difluoroethane   Ind.......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
   1649-08-7.                                                          DAY; 5/group.                            
  1,2-difluror-1,1,2,2-tetra-        Solv......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
   chloroethane 76-12-0.                                               DAY; 5/group.                            
  Hexachloroethane 67-72-1.........  Solv......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group.                            
  Pentabromoethane 75-95-6.........  Ind.......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group.                            
  Pentachloroethane 76-01-7........  Solv......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group; female rats 0, 1,24        
                                                                       MMOL/KG/DAY;.                            
  1,1,1,2-tetrabromoethane 630-16-0  Ind.......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group.                            
  1,1,2,2-tetrabromoethane 79-27-6.  Flam......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group.                            
  1,1,1,2-tetrachloroethane 630-20-  Intr......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
   6.                                                                  DAY; 5/group.                            
  1,1,2,2-tetrachloroethane 79-34-5  Solv......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group.                            
  1,1,1-trichloroethane 71-55-6....  Solv......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
                                                                       DAY; 5/group.                            
  1,1,1-trichloro-2,2,2-             Ind.......  Gav.......  R......  Male rats 0, 0.62, 1.24 MMOL/KG/        45
   trifluoroethane 354-58-5.                                           DAY; 5/group.                            
----------------------------------------------------------------------------------------------------------------
                           Short-Term Toxicity Studies Scheduled for Peer Review 1994                           
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Cadium oxide 1306-19-0.............  Elec......  Inhal.....  Rm.....  R,M: 0, 0.025, 0.05, 0.1, 0.25 OR       39
                                                                       1.0 MG/M3 (10/S/S).                      
Cadium oxide 1306-19-0.............  Elec......  Inhal.....  Rm.....  Rats & Mice: 0, 0.025, 0.05, 0.1,       39
                                                                       0.25 OR 1.0 MG/MG (10/S/S).              
----------------------------------------------------------------------------------------------------------------
                       Short-Term Toxicity Studies Scheduled for Peer Review August 1994                        
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Methacrylonitrile 126-98-7.........  Plas......  Gav.......  Rm.....  R: 0,7.5,15.0,30.0,0,60.0,120.0 MG/     47
                                                                       KG/DAY; M: 0,0.75,1.5,3.0,6.0,12.0       
                                                                       MG/KG/DAY; RATS: 20/Grp; Mice: 10/       
                                                                       group.                                   
----------------------------------------------------------------------------------------------------------------
                      Short-Term Toxicity Studies Scheduled for Peer Review September 1994                      
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Benzophenone 119-61-9..............  Phar......  Feed......  Rm.....  R&M: 0,0.125,0.25,0.5,1.0,2.0%; R:        
                                                                       20/sex/grp; M: 10/SEX/group.             
M-chloroaniline 108-42-9...........  Intr......  Gav.......  Rm.....  R&M 0, 10, 20, 40, 80, 160 MG/KG,       43
                                                                       20/GRP (RATS); 10/group mice.            
O-chloroaniline 95-51-2............  Dye.......  Gav.......  Rm.....  R&M 0, 10, 20, 40, 80 & 160 MG/KG,      43
                                                                       20/Group (rats); 10/group mice.          
O-nitrotoluene 88-72-2.............  Rubr......  Feed......  R......  Male R: 0, 0 altered microflora 20/     44
                                                                       Grp; 5000 PPM 60/grp; 5000 ppm           
                                                                       altered microflora 40/group..            
3,3',4,4'-tetrachloro-azobenzene     Herb......  Gav.......  Rm.....  R&M: 0, 0.1, 1.0, 3.0, 10, OR 30 MG/      
 14047-09-7.                                                           KG body weight (M&F 10/group).          
3,3',4,4'-tetrachloro-azobenzene     Comt......  Gav.......  Rm.....  R&M: 0, 0.1, 1.0, 3.0, 10, OR 30 MG/      
 21232-47-3.                                                           KG body weight (M&F 10/group).          
O-toluidine hydrochloride 636-21-5.  Dye.......  Feed......  R......  O and 0 altered microflora; 20/         44
                                                                       group; 5000 PPM; 60 group.               
----------------------------------------------------------------------------------------------------------------
                       Short-Term Toxicity Studies Scheduled for Peer Review October 1994                       
----------------------------------------------------------------------------------------------------------------
                                                                                                                
Oxymetholone 434-07-1..............  Phar......  Gav.......  Rm.....  R: 0, 80, 160, 315, 625, OR 1250 MG/    49
                                                                       KG; 20/sex/group M: 0, 160, 320,         
                                                                       630, 1250, OR 2500 MG/KG; 10/sex/        
                                                                       group.                                   
1,1,1-trichloroethane 71-55-6......  Solv......  Micro.....  Rm.....  R&M: 0, 0.5, 1.0, 2.0, 4.0, and 8.0       
                                                                       % (10/S/S).                              
----------------------------------------------------------------------------------------------------------------

Abbreviations Used in this Report

Use: Primary Use Category:
Comt Contaminates and/or Impurities
Cosm Cosmetics, Perfumes, Fragrances, Hair Preparations, Skin 
Lotions
Dtrg Detergents and Cleansers
Dye As or in Dyes, Inks, and Pigments
Elec in Electrical and/or Dielectric Systems or Products
Envh Environmental (Air/Water) Pollutants
Flam Flame Retardants
Food Food, Beverages, or Additives
Fuel As or in Fuel or Oil Products
Germ Germicides, Disinfectants, Antiseptics
Herb Herbicide(s)
Ind Industrial Uses
Intr Chemical Intermediate or Catalyst
Labc Unspecified Chemical Uses not Fitting in SOLV, INTR, or REAG 
categories
Metl Metals or in Metal Products
Papr As or in Paper or Paper Products
Pest Pesticides, General or Unclassified
Phar Pharmaceuticals or Intermediates
Plas As or in Plastics
Pnt Paint Ingredient
Rubr Rubber Chemical
Solv Vehicles and Solvents
Texl In Manufacture of Textiles
Route Route of Administration:
Feed Dosed-Feed
Gav Gavage
Inhal Inhalation
IP/IJ Intraperitoneal Injection
Ivag Intravaginal
Micro Microencapsulation in Feed
SC&GV Subcutaneous Inj. + Gavage
SP Topical
Water Dosed-Water
Spec Species:
R = Rate
M = Mice

[FR Doc. 94-5493 Filed 3-9-94; 8:45 am]
BILLING CODE 4140-01-M