[Federal Register Volume 59, Number 40 (Tuesday, March 1, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-4603]


[[Page Unknown]]

[Federal Register: March 1, 1994]


-----------------------------------------------------------------------

DEPARTMENT OF DEFENSE
Department of the Army

 

Availability of Non-exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Application Concerning HIV Negative-Strand 
Transcripts

AGENCY: U.S. Army Medical Research and Development Command, DOD.

ACTION: Notice.
    In accordance with 37 CFR 404.6, announcement is made of the 
availability of U.S. Patent Application Serial Number 08/126,295 
entitled ``HIV Negative-Strand Transcripts'' filed September 24, 1993 
for licensing. This patent has been assigned to the United States 
government as represented by the Secretary of the Army.

ADDRESSES: Office of the Command Judge Advocate, U.S. Army Medical 
Research and Development Command, Fort Detrick, Frederick, Maryland 
21702-5012.

FOR FURTHER INFORMATION CONTACT:Mr. John F. Moran, Patent Attorney, 
(301) 619-2065.

SUPPLEMENTARY INFORMATION: The invention relates to HIV transcripts of 
negative-strand polarity in HIV-infected cells, the cloning of cDNAs 
derived from negative-strand transcripts, and to genetically engineered 
host cells which express the negative-strand encoded proteins. The 
invention also relates to HIV sequences that function to promote 
transcription of the negative-strand RNAs and the demonstration of 
these RNAs. The identification of negative-strand polarity extends the 
coding capacity of HIV and suggest a role for antisense regulation of 
the HIV viral lytic cycle. The negative-strand transcripts and their 
encoded protein products may be used as research reagents, diagnostic 
products, or therapeutic products. Regulation of negative-strand 
transcription may be used in therapeutic intervention, or as a target 
for drug development.
Kenneth L. Denton,
Army Federal Register Liaison Officer.
[FR Doc. 94-4603 Filed 2-28-94; 8:45 am]
BILLING CODE 3710-08-M