[Federal Register Volume 59, Number 34 (Friday, February 18, 1994)]
[Unknown Section]
[Page 0]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 94-3782]


[[Page Unknown]]

[Federal Register: February 18, 1994]


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DEPARTMENT OF ENERGY
Office of Energy Research

 

Energy Research Financial Assistance Program Notice 94-12: Human 
Genome Program--Technological Advances

AGENCY: Department of Energy (DOE).

ACTION: Notice inviting grant applications.

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SUMMARY: The Office of Health and Environmental Research (OHER) of the 
Office of Energy Research (ER), U.S. Department of Energy (DOE), hereby 
announces its interest in receiving applications in support of the 
Human Genome Program. This Program is a coordinated, multidisciplinary, 
goal oriented, research effort aimed at improving technologies that 
will lead to a detailed understanding of the human genome at the 
molecular level. Several research goals are encompassed in this notice, 
with collaborative, multidisciplinary efforts specifically encouraged. 
Research will be supported for the development of: (1) Integrated 
approaches to large-scale human genome sequencing that may include 
supportive mapping and automation; (2) cost-effective DNA sequencing 
systems that promise more than a 10-fold improvement in throughput; (3) 
software and resources for real-time analysis and annotation of data 
from high-speed DNA sequencing systems; (4) resources for facile entry 
and retrieval of data in community genome maps and DNA sequence 
databases, including coordinated entry or retrieval across multiple, 
complementary databases.

DATES: Formal applications submitted in response to this notice must be 
received by 4:30 p.m., E.D.T., July 14, 1994, to be accepted for merit 
review in September 1994, and to permit timely consideration for award 
in Fiscal Year 1995.

ADDRESSES: Formal applications referencing Program Notice 94-12 should 
be forwarded to: U.S. Department of Energy, Office of Energy Research, 
Acquisition and Assistance Management Division, ER-64 (GTN), 
Washington, DC 20585, ATTN: Program Notice 94-12. The following address 
must be used when submitting applications by U.S. Postal Service 
Express Mail or any commercial mail delivery service, or when 
handcarried by the applicant: U.S. Department of Energy, Office of 
Energy Research, Acquisition and Assistance Management Division, ER-64, 
19901 Germantown Road, Germantown, MD 20874.

FOR FURTHER INFORMATION CONTACT: Dr. David A. Smith, Office of Health 
and Environmental Research, ER-72 (GTN), Office of Energy Research, 
U.S. Department of Energy, Washington, DC 20585, (301) 903-6488.

SUPPLEMENTARY INFORMATION: Potential applicants are strongly encouraged 
to submit a brief preapplication in accordance with 10 CFR 
600.10(d)(2), that consists of two to three pages of narrative 
describing the research project objectives and methods of 
accomplishment. These will be reviewed relative to the scope and 
research needs of the DOE's Human Genome Program. Preapplications 
referencing Program Notice 94-12 should be received by April 15, 1994, 
and sent to Dr. David A. Smith, Office of Health and Environmental 
Research, ER-72 (GTN), Washington, DC 20585. Telephone and FAX numbers 
are required parts of the preapplication and electronic mail addresses 
are desirable. A response to the preapplications discussing the 
potential program relevance of a formal application generally will be 
communicated within 30 days of receipt.
    It is anticipated that approximately $5,000,000 will be available 
for grant awards during FY 1995, contingent upon availability of 
appropriated funds. Multiple year funding of grant awards is expected, 
and is also contingent upon availability of funds. Previous awards have 
ranged from $79,000 per year up to $1,000,000 per year with terms from 
one to three years. Most awards are in the $200,000 to $400,000 per 
year range for three years. Similar award sizes are anticipated for new 
grants. Information on the development and submission of applications, 
eligibility, limitations, evaluation, selection process, and other 
policies and procedures may be found in the Application Guide for the 
Office of Energy Research Financial Assistance Program and 10 CFR part 
605. The Application Guide is available from the U.S. Department of 
Energy, Office of Health and Environmental Research, Health Effects and 
Life Sciences Research Division, ER-72 (GTN), Washington, DC 20585. 
Telephone requests may be made by calling (301) 903-6488.
    The Office of Energy Research, as part of its grant regulations, 
requires at 10 CFR 605.11(b) that a grantee funded by ER and performing 
research involving recombinant DNA molecules and/or organisms and 
viruses containing recombinant DNA molecules shall comply with the 
National Institutes of Health ``Guidelines for Research Involving 
Recombinant DNA Molecules'' (51 FR 16958, May 7, 1986), or such later 
revision of those guidelines as may be published in the Federal 
Register.
    The dissemination of materials and research data in a timely manner 
is essential for progress towards the goals of the DOE Human Genome 
Program. The OHER requires the timely sharing of resources and data. 
Applicants should, in their applications, discuss their plans for 
disseminating research data and materials that may include, where 
appropriate, putting cell lines, probes, sequence data, software, etc., 
into public repositories. Once OHER and the applicant have agreed upon 
a distribution plan, it will become part of the award conditions. Funds 
to defray the costs of disseminating materials or submitting data to 
repositories are allowable; however, such requests must be adequately 
justified. Applicants should also provide timelines projecting progress 
toward achieving proposed goals.

    The Catalog of Federal Domestic Assistance Number for this 
program is 81.049.

    Issued in Washington, DC, on February 8, 1994.
D.D. Mayhew,
Director, Office of Management, Office of Energy Research.
[FR Doc. 94-3782 Filed 2-17-94; 8:45 am]
BILLING CODE 6450-01-P