[Congressional Record Volume 153, Number 9 (Wednesday, January 17, 2007)]
[Extensions of Remarks]
[Pages E134-E135]
From the Congressional Record Online through the Government Publishing Office [www.gpo.gov]




               STEM CELL RESEARCH ENHANCEMENT ACT OF 2007

                                 ______
                                 

                               speech of

                         HON. JEFF FORTENBERRY

                              of nebraska

                    in the house of representatives

                       Thursday, January 11, 2007

  Mr. FORTENBERRY. Mr. Speaker, please find attached references which 
conclusively demonstrate the therapeutic benefits experienced by human 
patients who have undergone a variety of adult stem cell treatments. 
These references are available at www.stemcellresearch.org. Also, 
please find attached the text of a Wall Street Journal article on 
November 16, 2006, citing progress on amniotic stem cell research as 
referenced in my floor statement during the January 11 debate on H.R. 
3.

Peer-Reviewed References Showing Applications of Adult Stem Cells That 
             Produce Therapeutic Benefit for Human Patients


              ADULT STEM CELLS--HEMATOPOIETIC REPLACEMENT

                                CANCERS

       Brain Tumors--medulloblastoma and glioma. Dunkel, IJ; 
     ``High-dose chemotherapy with autologous stem cell rescue for 
     malignant brain tumors''; Cancer Invest. 18,492-493; 2000.
       Ovarian Cancer--Stiff PJ et al.; ``High-dose chemotherapy 
     and autologous stem-cell transplantation for ovarian cancer: 
     An autologous blood and marrow transplant registry report''; 
     Ann. Intern. Med. 133, 504-515; Oct. 3, 2000. Schilder, RJ 
     and Shea, TC; ``Multiple cycles of high-dose chemotherapy for 
     ovarian cancer''; Semin. Oncol. 25, 349-355; June 1998.
       Testicular Cancer--Bhatia S et al.; ``High-dose 
     chemotherapy as initial salvage chemotherapy in patients with 
     relapsed testicular cancer''; J. Clin. Oncol. 18, 3346-3351; 
     Oct. 19, 2000.
       Lymphoma--Josting, A; ``Treatment of Primary Progressive 
     Hodgkin's and Aggressive Non-Hodgkin's Lymphoma: Is There a 
     Chance for Cure?''; J Clin Oncol 18, 332-339; 2000. Koizumi M 
     et al.; ``Successful treatment of intravascular malignant 
     lymphomatosis with high-dose chemotherapy and autologous 
     peripheral blood stem cell transplantation''; Bone Marrow 
     Transplant 27, 1101-1103; May 2001.
       Acute Lymphoblastic Leukemia--Laughlin MJ et al.; 
     ``Hematopoietic engraftment and survival in adult recipients 
     of umbilical-cord blood from unrelated donors'', New England 
     Journal of Medicine 344, 1815-1822; June 14, 2001.
       Breast Cancer--Damon LE et al.; ``High-dose chemotherapy 
     and hematopoietic stem cell rescue for breast cancer: 
     experience in California''; Biol. Blood Marrow Transplant 6, 
     496-505; 2000.


    ADULT STEM CELLS--IMMUNE SYSTEM REPLACEMENT AUTOIMMUNE DISEASES

       Systemic Lupus--Burt RK et al., Nonmyeloablative 
     hematopoietic stem cell transplantation for systemic lupus 
     erythematosus, Journal of the American Medical Association 
     295, 527-535, February 1, 2006.
       Crohn's Disease--Burt RK et al., ``High-dose immune 
     suppression and autologous hematopoietic stem cell 
     transplantation in refractory Crohn disease,'' Blood 101, 
     2064-2066, March 2003.
       Juvenile Arthritis--IM de Kleer et al., Autologous stem 
     cell transplantation for refractory juvenile idiopathic 
     arthritis: analysis of clinical effects, mortality, and 
     transplant related morbidity, Ann Rheum Dis 63, 1318-1326, 
     2004.
       Multiple Sclerosis--Saccardi R et al., Autologous HSCT for 
     severe progressive multiple sclerosis in a multicenter trial: 
     impact on disease activity and quality of life, Blood 105, 
     2601-2607, 15 March 2005.


                   ANEMIAS and OTHER BLOOD CONDITIONS

       Sickle Cell Anemia--Klein A et al., Hematopoietic stem cell 
     transplantation for severe sickle cell disease, Rev Med Brux. 
     2005; 26 Spec no: Sp23-5.
       Chronic Epstein-Barr Infection--Fujii N et al.; 
     ``Allogeneic peripheral blood stem cell transplantation for 
     the treatment of chronic active epstein-barr virus 
     infection''; Bone Marrow Transplant 26, 805-808; Oct. 2000.


    ADULT STEM CELLS--REPAIR/REPLACEMENT OF SOLID TISSUES METABOLIC 
                               DISORDERS

       Osteopetrosis--Tsuji Y et al., Successful nonmyeloablative 
     cord blood transplantation for an infant with malignant 
     infantile osteopetrosis, J Pediatr Hematol Oncol. 27, 495-
     498, Sept 2005.


                                 OCULAR

       Corneal Regeneration--Inatomi T et al., Midterm results on 
     ocular surface reconstruction using cultivated autologous 
     oral mucosal epithelial transplantation, American Journal of 
     Ophthalmology 141, 267-275, February 2006.


                           WOUNDS & INJURIES

       Limb Gangrene--Tateishi-Yuyama E et al., ``Therapeutic 
     angiogenesis for patients with limb ischaemia by autologous 
     transplantation of bone-marrow cells: a pilot study and a 
     randomized controlled trial''; Lancet 360, 427-435; 10 August 
     2002.


                              HEART DAMAGE

       Acute Heart Damage--Joseph J et al., Safety and 
     effectiveness of granulocyte-colony stimulating factor in 
     mobilizing stem cells and improving cytokine profile in 
     advanced chronic heart failure, American Journal of 
     Cardiology 97, 681-684, 1 March 2006.
       Chronic Coronary Artery Disease--Strauer BE et al., 
     Regeneration of human infarcted heart muscle by intracoronary 
     autologous bone marrow cell transplantation in chronic 
     coronary artery disease, Journal of the American College of 
     Cardiology 46, 1651-1658, 1 November 2005.


                NEURAL DEGENERATIVE DISEASES & INJURIES

       Stroke--Shyu W-C et al., Granulocyte colony-stimulating 
     factor for acute ischemic stroke: a randomized controlled 
     trial, Canadian Medical Association Journal 174, 927-933, 28 
     March 2006.


                          Parkinson's Disease

       Using Direct Stimulation of Patients' Endogenous Adult 
     Neural Stem Cells--Love S et al., Glial cell line-derived 
     neurotrophic factor induces neuronal sprouting in human 
     brain, Nature Medicine 11, 703-704, July 2005.
       Slevin JT et al., Improvement of bilateral motor functions 
     in patients with Parkinson disease through the unilateral 
     intraputaminal infusion of glial cell line-derived 
     neurotrophic factor, Journal of Neurosurgery 102, 216-222, 
     February 2005.
       Spinal Cord Injury--Lima C et al., Olfactory mucosa 
     autografts in human spinal cord injury: A pilot clinical 
     study, Journal of Spinal Cord Medicine 29, 191-203, July 
     2006.


                             LIVER DISEASE

       Liver Cirrhosis--Terai S et al., Improved liver function in 
     liver cirrhosis patients after autologous bone marrow cell 
     fusion therapy, Stem Cells published online 15 June 2006; 
     DOI: 10.1634/stemcells.2005-0542.


                            BLADDER DISEASE

       End-Stage Bladder Disease--Atala A et al., Tissue-
     engineered autologous bladders for patients needing 
     cytoplasty, The Lancet 367, 1241-1246, 15 April 2006.
                                  ____


       Scientists Grow Heart Valves Employing Amniotic Stem Cells

       Chicago--Scientists for the first time have grown human 
     heart valves using stem cells from the fluid that cushions 
     babies in the womb--offering a revolutionary approach that 
     may be used to repair defective hearts in the future.

[[Page E135]]

       The idea is to create new valves in the lab while the 
     pregnancy progresses and have them ready to implant in a baby 
     with heart defects after it is born.
       The Swiss experiment follows recent success growing 
     bladders and blood vessels and suggests people may one day be 
     able to grow their own replacement heart parts--in some 
     cases, before they're born.
       It's one of several sci-fi tissue engineering advances that 
     could lead to homegrown heart valves for infants and adults 
     that are more durable and effective than artificial or 
     cadaver valves.
       ``This may open a whole new therapy concept to the 
     treatment of congenital heart defects,'' said Dr. Simon 
     Hoerstrup, a University of Zurich scientist who led the work, 
     which was presented yesterday at an American Heart 
     Association conference.
       Also at the meeting, Japanese researchers said they had 
     grown new heart valves in rabbits using cells from the 
     animals' own tissue. It is the first time replacement heart 
     valves have been created in this manner, said lead author Dr. 
     Kyoko Hayashida.
       One percent of all newborns, or more than one million 
     babies born world-wide each year, have heart problems. These 
     kill more babies in the U.S. in the first year of life than 
     any other birth defect, according to the National Institutes 
     of Health.
       Heart-valve defects can be detected with ultrasound tests 
     at about 20 weeks of pregnancy. At least one-third of 
     afflicted infants have problems that could be treated with 
     replacement valves, Dr. Hoerstrup said.
       Conventional procedures to fix faulty heart valves all have 
     drawbacks. Artificial valves are prone to blood clots and 
     patients must take anticlotting drugs for life. Valves from 
     human cadavers or animals can deteriorate, requiring repeated 
     open-heart surgeries to replace them, Dr. Hijazl said. That's 
     especially true in children, because these valves don't grow 
     along with the body. Valves made from the patient's own cells 
     are living tissue and might be able to grow with the patient, 
     said Dr. Hayashida, a scientist at the National 
     Cardiovascular Center Research Institute in Osaka.
       The Swiss procedure has another advantage: using cells the 
     fetus sheds in amniotic fluid avoids controversy because it 
     doesn't involve destroying embryos to get stem cells.

                          ____________________