[Senate Hearing 105-180]
[From the U.S. Government Publishing Office]


                                                        S. Hrg. 105-180

 
 RADIOACTIVE FALLOUT FROM NUCLEAR TESTING AT NEVADA TEST SITE, 1950-60

=======================================================================

                                HEARING

                                before a

                          SUBCOMMITTEE OF THE

            COMMITTEE ON APPROPRIATIONS UNITED STATES SENATE

                       ONE HUNDRED FIFTH CONGRESS

                             FIRST SESSION

                               __________

                            SPECIAL HEARING

                               __________

         Printed for the use of the Committee on Appropriations


 Available via the World Wide Web: http://www.access.gpo.gov/congress/
                                 senate

                                 ______


                     U.S. GOVERNMENT PRINTING OFFICE
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                      COMMITTEE ON APPROPRIATIONS

                     TED STEVENS, Alaska, Chairman
THAD COCHRAN, Mississippi            ROBERT C. BYRD, West Virginia
ARLEN SPECTER, Pennsylvania          DANIEL K. INOUYE, Hawaii
PETE V. DOMENICI, New Mexico         ERNEST F. HOLLINGS, South Carolina
CHRISTOPHER S. BOND, Missouri        PATRICK J. LEAHY, Vermont
SLADE GORTON, Washington             DALE BUMPERS, Arkansas
MITCH McCONNELL, Kentucky            FRANK R. LAUTENBERG, New Jersey
CONRAD BURNS, Montana                TOM HARKIN, Iowa
RICHARD C. SHELBY, Alabama           BARBARA A. MIKULSKI, Maryland
JUDD GREGG, New Hampshire            HARRY REID, Nevada
ROBERT F. BENNETT, Utah              HERB KOHL, Wisconsin
BEN NIGHTHORSE CAMPBELL, Colorado    PATTY MURRAY, Washington
LARRY CRAIG, Idaho                   BYRON DORGAN, North Dakota
LAUCH FAIRCLOTH, North Carolina      BARBARA BOXER, California
KAY BAILEY HUTCHISON, Texas
                   Steven J. Cortese, Staff Director
                 Lisa Sutherland, Deputy Staff Director
               James H. English, Minority Staff Director
                                 ------                                

 Subcommittee on Departments of Labor, Health and Human Services, and 
                    Education, and Related Agencies

                 ARLEN SPECTER, Pennsylvania, Chairman
THAD COCHRAN, Mississippi            TOM HARKIN, Iowa
SLADE GORTON, Washington             ERNEST F. HOLLINGS, South Carolina
CHRISTOPHER S. BOND, Missouri        DANIEL K. INOUYE, Hawaii
JUDD GREGG, New Hampshire            DALE BUMPERS, Arkansas
LAUCH FAIRCLOTH, North Carolina      HARRY REID, Nevada
LARRY E. CRAIG, Idaho                HERB KOHL, Wisconsin
KAY BAILEY HUTCHISON, Texas          PATTY MURRAY, Washington
                      Majority Professional Staff
                  Craig A. Higgins and Bettilou Taylor

                      Minority Professional Staff
                              Marsha Simon

                         Administrative Support
                              Jim Sourwine


                            C O N T E N T S

                              ----------                              
                                                                   Page
Opening remarks of Senator Arlen Specter.........................     1
Opening remarks of Senator Tom Harkin............................     2
Prepared statement of Senator Harry Reid.........................     4
Prepared statement of Senator Patty Murray.......................     3
Opening remarks of Senator Larry Craig...........................     6
    Prepared statement...........................................     6
Atmospheric tests................................................     7
Statement of Hon. Richard D. Klausner, M.D., Director, National 
  Cancer Institute, Department of Health and Human Services......     8
    Prepared statement...........................................    10
Statement of Joseph Lynn Lyon, M.D., M.P.H., professor, 
  Department of Family and Preventive Medicine, University of 
  Utah School of Medicine........................................    17
    Prepared statement...........................................    20
No funding for study.............................................    25
Statement of Jan Beyea, Ph.D., senior scientist, Consulting in 
  the Public Interest............................................    26
    Prepared statement...........................................    28
Institute of Medicine............................................    34
Statement of Timothy Connor, associate director, Energy Research 
  Foundation.....................................................    34
    Prepared statement...........................................    37
Followup study...................................................    41
Statement of Andrea McGuire, M.D., staff physician, Veterans 
  Administration Hospital, Des Moines, IA........................    42
    Prepared statement...........................................    43
Tests............................................................    44
Followup studies not made........................................    47
Remarks of Senator Slade Gorton..................................    52
Letter from Dr. Richard D. Klausner..............................    58
Letters from Senator Tom Daschle.................................    58
Isotope..........................................................    59
Statement of Arjun Makhijani, coauthor, article, ``Bulletin of 
  Atomic Scientists''............................................    60
Prepared statement of Senator Dirk Kempthorne....................    63
Prepared statement of Peter G. Crane.............................    63
  


 RADIOACTIVE FALLOUT FROM NUCLEAR TESTING AT NEVADA TEST SITE, 1950-60

                              ----------                              


                       WEDNESDAY, OCTOBER 1, 1997

                           U.S. Senate,    
    Subcommittee on Labor, Health and Human
     Services, and Education, and Related Agencies,
                               Committee on Appropriations,
                                                    Washington, DC.
    The subcommittee met at 9:04 a.m., in room SD-192, Dirksen 
Senate Office Building, Hon. Arlen Specter (chairman) 
presiding.
    Present: Senators Specter, Gorton, Craig, Faircloth, 
Harkin, Reid, and Murray.

                DEPARTMENT OF HEALTH AND HUMAN SERVICES

                       National Cancer Institute

STATEMENT OF RICHARD D. KLAUSNER, M.D., DIRECTOR


                   opening remarks of senator specter


    Senator Specter. We will begin this hearing, which focuses 
on the findings of the National Cancer Institute report on 
radioactive fallout from nuclear testing at the Nevada Test 
Site in the 1950's and 1960's. Dr. Richard Klausner, the 
Director NCI, will begin the hearing, with the principal 
investigators of this study, Mr. Bruce Wachholz and Mr. Andre 
Bouville, available to answer questions. Then we will have four 
witnesses who will evaluate the NCI hearing on a number of 
grounds.
    Atmospheric nuclear bomb testing in Nevada yielded 
significant amounts of radioactive fallout. In 1982 Congress 
passed legislation directing HHS to develop methods of 
estimating the varieties of exposure to the American people, to 
assess thyroid doses received by the individuals from across 
the Nevada desert and individuals all the way across the 
country who were impacted by the Nevada test, and to assess the 
risks of thyroid cancers from these exposures.
    This is a very important hearing. We had planned on the 
subcommittee to do the hearing earlier, but it was impossible 
to schedule it before October 1. This falls on the first day of 
the new fiscal year and we have a meeting on our conference 
report for Labor, Health, Human Services, and Education.
    The subcommittee will ask you, Dr. Klausner--your full 
statement will be made part of the record, as will all the 
statements--if you can limit your testimony opening to 5 
minutes, and we will ask the witnesses to speak 3 minutes, 
limiting the rounds of questioning, depending on how many 
Senators arrive, to 3 minutes as well.
    I regret the time constraints, but I say we do have to 
complete action on this legislation for important reasons, 
including funding the National Cancer Institute.
    My distinguished ranking member, Senator Harkin.


                 OPENING REMARKS OF SENATOR TOM HARKIN


    Senator Harkin. Thank you, Chairman Specter, for your 
leadership, for working to convene this hearing on an issue of 
great importance to the people of my State and the country. I 
am sorry about the time constraints because I think this needs 
a full hearing, and there probably has to be some follow-up 
hearings on this issue and the issue of other possible health 
effects from radioactive fallout from nuclear testing in the 
1950's.
    We have a number of expert witnesses. Dr. Richard Klausner 
of the National Cancer Institute, I thank him for being here. I 
also want to welcome and thank Dr. Andrea McGuire for coming 
from Iowa for the hearing today. Dr. McGuire is an oncologist 
from Des Moines who will provide both a professional and 
personal perspective about this issue.
    This morning we are here to get answers, to try to get to 
the truth. The report being released today by the National 
Cancer Institute is an important step forward. The NCI study 
details the health impact of iodine-131, a radioactive isotope 
spread across the United States by the 90 above-ground nuclear 
weapons tests conducted in Nevada during the 1950's. These 
tests exposed millions of Americans, particularly children, to 
large amounts of radioactive iodine-131, which accumulates in 
the thyroid gland and has been linked to thyroid cancer.
    Hot spots where the iodine-131 fallout was greatest 
included many areas far away from Nevada, including New England 
and the Midwest. Due to the character of iodine-131, those 
exposed to the highest concentrations were those who drank 
large amounts of milk from cows that grazed in fields with 
large fallout. Because their thyroids are smaller and still 
growing, children were most vulnerable.
    Hot spots were identified as receiving 5 to 16 rads or 
higher of exposure to iodine-131, with children being exposed 
to a risk of up to 10 times higher. To put that in perspective, 
Federal standards for nuclear power plants require that 
protective action be taken for 15 rads. Or to compare it 
another way, over 115 million curies of iodine-131 were 
released in the U.S. above-ground tests. 7.3 million curies 
were released from the Chernobyl disaster.
    This issue hits very close to home for me. In the 1950's I 
was growing up in south central Iowa, a small town. Along with 
many Iowans, I lived in hot spots detailed by the NCI study. 
And, like many of my neighbors, I drank milk from cows that 
grazed in the fields.
    My family has a history of thyroid problems, my brother 
Chuck, myself. And I think Dr. McGuire will testify about 
what's happened in her family.
    When it comes to the Government and nuclear testing, 
history shows the problem has not just been a fallout of 
radiation, but a holdout of facts. Information has come to 
light that officials of the U.S. Government were aware that 
fallout from nuclear blasts would contaminate areas that were 
hundreds, even thousands, of miles away.
    An article by Pat Ortmeyer and Arjun Makhijani which will 
appear in the upcoming issue of the Bulletin of Atomic 
Scientists documents some of this in chilling detail. Start 
first with the first nuclear test in New Mexico in July of 
1945. The so-called Trinity test resulted in one hot spot all 
the way in Indiana. How do we know that? Corn husks from that 
area were used as packaging material for Kodak film, and a 
month after the 1945 test consumers started complaining about 
fogged film. A physicist at Eastman Kodak looked into it and 
uncovered the cause: The corn husks were radioactively 
contaminated.
    Now fast forward 6 years to the first nuclear test in 
Nevada. After a snowfall, the geiger counters at the Kodak 
plant in Rochester, New York, registered readings 25 times 
above normal. Kodak complained to the Atomic Energy Commission 
and that Government agency agreed to give Kodak advanced 
information on future tests, including ``expected distribution 
of radioactive material in order to anticipate local 
contamination.''
    In fact, the Government warned the entire photographic 
industry and provided maps and forecasts of potential 
contamination. Where, I ask, were the maps for dairy farmers? 
Where were the warnings to parents of children in these areas?
    So here we are, Mr. Chairman. The Government protected 
rolls of film, but not the lives of our kids. There is 
something wrong with this picture.
    Now, the NCI study has attracted a lot of attention, and 
that is not surprising from a report detailing exposure to 
millions of Americans. However, there is also a controversy 
over the manner in which the study was conducted. Several 
organizations and many of my constituents have expressed 
concern over the apparent delay in the release of the study, 
and I appreciate that Dr. Klausner is here to shed light on 
that.
    I believe there are three areas we need to explore: First, 
what are the facts concerning the preparation and release of 
the NCI report and why did it take 15 years to complete? 
Second, what are the next scientific steps in investigating 
radioactive fallout from atomic weapons testing? What other 
fallout was there that could have affected us in terms of 
childhood leukemia and bone cancer?
    Last, what are the health policy impacts of the NCI study? 
What should concerned citizens do if they live in a high-risk 
area? What should the Federal Government communicate to 
physicians and other public health officials? What should be 
the role for the Center for Disease Control and Prevention in 
alerting public health officials around the country?
    Last, we should get to the bottom of why, why the 
Government alerted the photographic industry? Why did they do 
that when they had all the information about hot spots and 
fallout, and yet they did not warn the people of this country 
about the dangers inherent in radioactive fallout, especially 
iodine-131?
    Mr. Chairman, I did not mean to take so long. But I believe 
this hearing is crucial to getting at the bottom of this and to 
beginning a process, hopefully, of alerting public health 
officials and others around the country as to just what should 
be done. And I think we ought to get to the bottom, as I said, 
of what was our Government's role in not alerting the public 
during the 1950's and early 1960's.
    Mr. Chairman, thank you.
    Senator Specter. Thank you very much, Senator Harkin.
    For the members who have just arrived, I had announced 
earlier that Senator Harkin and I have a responsibility on the 
conference. We are going to have to conclude the hearing in 1 
hour. Ordinarily we move ahead on--while it is not the practice 
of many committees, we do allow opening statements. But I would 
ask that those be waived this morning so that we can proceed 
with the hearing.
    We are going to give Dr. Klausner 5 minutes and the 4 
witnesses 3. Senator Craig may be able to stay longer. We may 
have to reconvene the hearing and go into it in more detail. 
But as I said earlier, this is the first day of the new fiscal 
year and we are under constraints to get a conference report 
done. We are meeting on that with House Members, so we have 
that very substantial time constraint.


                   PREPARED STATEMENT OF SENATOR REID


    Senator Reid. Mr. Chairman, may I ask unanimous consent 
that my full statement be made part of the record?
    Senator Specter. Absolutely, Senator Reid.
    [The statement follows:]

                Prepared Statement of Senator Harry Reid

              HEALTH RISKS OF ATMOSPHERIC NUCLEAR TESTING

    The National Cancer Institute was asked to respond to 
legislation requiring a valid and credible assessment of 
exposure of U.S. citizens to radioactive Iodine-131 resulting 
from fallout from atmospheric testing of nuclear weapons.
    It is no longer surprising that many American citizens were 
placed at risk by atmospheric testing.
    The surprises are in the nation-wide character of the 
exposure and the levels of exposure experienced by citizens 
living so far from the Test Site.
    While the passage of time continues to reduce the threat 
level, it is important to realize that the threat of exposure 
from these tests is still with us.
    The half-life of Iodine-131 is only about 8 days, so that 
material that was not taken up by individuals within several 
weeks of the tests is no longer of concern.
    However, other fallout ingredients have much longer periods 
of radioactivity. For example, Strontium-90 and Cesium-137 have 
half-lives of about 30 years. These are also taken up by the 
body and exhibit radioactive emissions very similar to Iodine-
131.
    Consequently, the Iodine-131 study, which is continuing, 
should continue. But this study addresses only a part of the 
story. Other exposure threats and the resulting risk to 
succeeding generations need to be considered.
    The tools and methodologies developed for Iodine-131 
exposure will provide much of what is needed to consider other 
radioactive threats from this critical period in our nation's 
pursuit of global peace and security.
    I would be remiss if I did not point out the obvious: our 
citizens were neither knowingly nor frivolously exposed to 
risk. Well-meaning scientists and civic and political leaders 
assured themselves and their constituencies that there was 
negligible risk in these tests that were so important to our 
national security.
    It was not until much later that the magnitude and duration 
of the risk became more and more evident.
    We should learn from past mistakes.
    The mistake in this case was one of proceeding with 
terribly intrusive and risky actions before enough was 
understood about all the uncertainties surrounding the 
activity.
    Underground testing could have been used from the outset. 
It was not until the risks became more evident that the time 
and expense of moving the tests underground was accommodated.
    Well, we are in the process of once again trying to repeat 
this kind of mistake.
    Permanent disposal of spent nuclear fuel and high level 
radioactive waste is subject to even greater uncertainties than 
was the original atmospheric testing program.
    Yet, some are making Herculean efforts to circumvent the 
absolutely crucial process of understanding the suitability of 
the proposed disposal site and methodology.
    The amounts and intensity of radioactive materials that 
would be dumped in Nevada far exceed that associated with all 
of the nuclear weapons ever exploded anywhere * * * and there 
is no guarantee that this dangerous stuff would be isolated 
from the environment throughout its hazardous period of 10,000 
years.
    There is no national security crisis, nor is there any 
other kind of emergency that would warrant doing anything at 
all until the consequences of disposal actions are well and 
confidently understood.


                  PREPARED STATEMENT OF SENATOR MURRAY


    Senator Murray. I as well ask unanimous consent that my 
full statement be made part of the record.
    Senator Specter. Senator Murray as well.
    [The statement follows:]

               Prepared Statement of Senator Patty Murray

    Good morning and welcome to all of our distinguished 
witnesses. I want to say a special hello and thanks to Tim 
Conner, Associate Director of the Energy Research Foundation of 
Spokane, Washington who will be testifying later. Tim is an 
active health and environmental researcher and was a founder of 
a public interest organization that works on issues of nuclear 
weapons production and environmental restoration. I hope I will 
have the opportunity to hear his testimony, but I am also 
looking forward to meeting with him personally later today. I 
appreciate all of your work, Tim.
    I also want to thank the chairman and ranking member for 
holding this hearing. I share the concern of many constituents 
and people across the nation who have been horrified to learn 
of the radiation ``experiments'' on unknowing citizens 
perpetrated by our government. Of course, it was a different 
world in the 1940's and 1950's and we were fighting a Cold War. 
The United States government made mistakes in its haste, fear 
and ignorance.
    But I cannot understand why the National Cancer Institute 
has allegedly withheld information now, in the 1990's, after we 
had won the Cold War. It is reprehensible that our citizens 
were intentionally exposed to radioactivity and yet those who 
knew remained silent--even in the face of evidence that said if 
we provided treatment and information early, we might alleviate 
suffering or prevent diseases.
    In my home state of Washington, the Atomic Energy 
Commission conducted its own tests and released radioactive 
iodine into the air from the Hanford Nuclear Reservation. Many 
people in central and eastern Washington were exposed. Despite 
several major studies and research projects, we are still 
uncertain about which direction to take. The Pacific Northwest 
National Laboratory has compiled data on radioactive releases 
and attempted to estimate the doses individuals received and 
published its results in the Hanford Environmental Dose 
Reconstruction study. The Centers for Disease Control and Fred 
Hutchison Cancer Research Center are now completing a long-term 
study on thyroid disease and are expected to finish that 
enormous undertaking next year. The Agency for Toxic Substances 
and Disease Registry has issued a medical monitoring plan, but 
has yet to locate a source of funding to implement the plan. 
The Hanford Health Information Network is trying to locate, 
catalog and help educate potential victims. And these are only 
a few of the studies and programs on-going to address the 
Hanford downwinders problems.
    While we have a lot of activity surrounding these issues, 
we seem to be shorter on action. I believe the bottom line is 
the federal government must accept responsibility for harming 
its citizens. It must apologize. And it must help these people 
with medical bills. These things are the very minimum we must 
do.
    I look forward to working with this committee to develop a 
comprehensive policy to address the grievances of our citizens. 
This is a complex area, but one that has been ignored for too 
long. Let's figure out what our citizens need--and do it.

                 OPENING REMARKS OF SENATOR LARRY CRAIG

    Senator Craig. Mr. Chairman.
    Senator Specter. Senator Craig.
    Senator Craig. Mr. Chairman, let me say only briefly that 
preliminary releases of information in August suggest that four 
out of the five counties with the greatest concern are in my 
State of Idaho, and as a result of that there is a sense of 
urgency for good accurate knowledge and understanding. I 
expressed frustration then and you will hear me expressing 
frustration throughout this hearing as the information unfolds.

                           PREPARED STATEMENT

    Senator Harkin expresses his frustration about time and 
length of time. While the citizens of Idaho and this Senator do 
not want nor will we rush to judgment, there is certainly a 
crying demand for knowledge and understanding of what may or 
may not have happened.
    I will ask unanimous consent that my full statement be a 
part of the record, Mr. Chairman.
    [The statement follows:]

               Prepared Statement of Senator Larry Craig

    Mr. Chairman, I am pleased to be here today and I thank you 
for holding this hearing on an important issue--one especially 
important to Idaho.
    Today the National Cancer Institute releases its full 
report on iodine-131 fallout from above ground nuclear weapons 
tests. The report runs to some 100,000 pages, I am told. The 
summary alone is 1,000 pages.
    Since it is being released just today, neither I nor my 
staff have yet had the opportunity to review these results.
    According to preliminary results released by the National 
Cancer Institute in August, however, the State of Idaho has 
four out of the five counties in the nation with the highest 
radiation exposure to iodine-131 from the fallout of these 
weapons tests.
    Individuals living in these five Idaho counties were 
estimated to have received a cumulative average dose of 12 to 
16 reds--with a 3 to 7 fold increase for children exposed 
between the ages of 3 months and 5 years.
    These results are of great interest and concern to me and 
to my fellow Idahoans. They are eager and impatient to 
understand what these results mean.
    Unfortunately, in reviewing today's testimony and culling 
from the vast public health resources available, I am afraid 
this is a question we will not be able to answer today for 
Idaho citizens and other exposed populations.
    I hope we will not spend all our time today trying to 
recreate the 14 year history of what the National Cancer 
Institute did, or should have done, in producing this study.
    I hope we will not spend our time today attempting to put 
the decisions this Nation made at the height of the Cold War 
under the microscope of our modern thinking.
    What I do believe to be our charge here is to assemble all 
the facts. This is what my constituents have asked of me.
    Simply knowing what the fallout levels were--a figure such 
as ``15 rads''--does not provide Idahoans with the information 
they need about possible health consequences. Specifically, the 
question that needs to be answered is:
    ``Do these levels of fallout result in an increased risk of 
thyroid cancer or other complications?''
    In reviewing the testimony of our witnesses, I know that 
some of them have already reached their conclusions on the 
health effects of these exposures, but there is a tremendous 
diversity of opinion on this.
    A number of health organizations are openly skeptical of 
any link between iodine-131 fallout and increased thyroid 
cancer.
    As an example, let me quote from the position statements of 
two national health organizations.
    The American Association of Clinical Endocrinologists 
states the following: ``Dozens of studies involving even much 
larger doses of iodine-131 given to adults and children have 
shown no correlation between iodine-131 and thyroid cancer. * * 
* Over the past fifty years, hundreds of thousands of patients 
have received iodine-131 for medical purposes, and there is no 
increase of thyroid cancer in these patients.''
    The American Thyroid Association states: ``Radioactive 
iodine has been used for more than 50 years in almost 10 
million individuals as part of routine thyroid function tests * 
* * in amounts far greater than that delivered by the fallout 
and careful long term follow-up studies of these individuals 
have not shown any evidence of excess thyroid cancer 
attributable to radiation exposure.''
    Perhaps the strongly conflicting opinions on this issue 
suggest the need for further and more conclusive study.
    As tragic as the events at Chernobyl and the nuclear 
contamination in the Former Soviet Union may be, the study of 
these exposed populations may be able to add to our 
understanding about the health effects of low levels of 
radiation exposure.
    I understand that cooperative research in these areas is 
already ongoing. I encourage these efforts.
    When we have completed more definitive work on this link 
between weapons fallout and cancer incidents--at that time--I 
believe Congress should look at any needed remedies.
    One avenue of remedy may be an expansion of programs 
already available to down wind exposed populations--or 
``downwinders,'' such as the Radiation Exposure Compensation 
Act of 1990.
    Another idea that may have merit is the use of a voluntary 
registry of individuals with thyroid health complications. It 
could be similar to registries developed for some of the 
Department of Energy dose reconstruction studies.
    Such a voluntary registry would allow those who want to 
participate in follow-up and long term medical monitoring to 
contribute to our very sparse data on low radiation dose health 
effects.
    I want to close by emphasizing that the most important 
thing right now is for those individuals who may have been put 
at increased risk to be provided with the facts and information 
they need to make informed decisions about their health, and 
any medical monitoring that may be required.
    Along these lines, I would like to see our national health 
organizations and government health institutes working 
together--and in cooperation with state and county health 
organizations--on a public education campaign about the early 
warning signs of thyroid disease.
    Such an education campaign would raise people's awareness 
and, hopefully, motivate them to seek early medical 
intervention, if needed.
    I am committed to seeing that populations exposed to this 
radioactive fallout get the information they need on this 
issue, in a timely way. I think our hearing today is a first 
step in this process.

                           ATMOSPHERIC TESTS

    Senator Reid. Mr. Chairman.
    Senator Specter. Senator Reid.
    Senator Reid. I would only say that I am probably the only 
person here that actually watched those atmospheric tests go 
off. We used to get up in the morning early and watch them 
light up the desert sky.
    Senator Specter. Just one note on the question of 
governmental disclosure. That is a recurrent problem, of 
greater intensity now than ever. We're fighting with gulf war 
syndrome, where the Department of Defense did not make facts 
available from a 1991 fallout until 1996. We are still in the 
midst, after having extensive hearings, on Ruby Ridge; on 
Khobar Towers, on the terrorist attack; and on INS and IRS.
    This is a very fundamental failing which we find in our 
Government today, which requires very intensive efforts.
    Dr. Klausner, we welcome you here. You have been before 
this committee many times. We thank you for your distinguished 
service, and the floor is yours.


               SUMMARY STATEMENT OF DR. RICHARD KLAUSNER


    Dr. Klausner. Thank you very much, Senators.
    One of the dark legacies of the above-ground nuclear tests 
was that 160 million Americans alive during that period were to 
varying degrees and unbeknownst to them exposed to radioactive 
fallout. On August 1st we released our study estimating 
exposures of thyroid doses of I-131 received by the American 
people, and today we release the details behind those results.
    This is a study of unprecedented magnitude, utilizing the 
limited data available for each of the 90-plus tests between 
1952 and 1958 responsible for 99 percent of the I-131 released 
into the atmosphere. These data were coupled with detailed wind 
patterns, rainfall patterns, grazing patterns of cows and 
goats, transfer patterns to milk, milk distribution and 
consumption patterns, and the results were then analyzed for 
all 3,000-plus counties in the 48 contiguous States for 13 age 
groups for multiple milk consumption patterns. The results are 
now available for each test, each series of tests, and 
cumulatively.
    Before I describe some of the results briefly, I must 
emphasize that there are significant uncertainties in these 
numbers. Because there were so few direct measurements at the 
time, much of the study relies on the development of 
mathematical and statistical models to estimate patterns and 
exposures.
    The average cumulative dose to all Americans was 2 rads. By 
county, the average cumulative exposure, as we heard, ranged up 
to 15 rads. But, importantly, the average cumulative exposures 
for children are between three and seven times those numbers, 
while for adults it is about one-third to one-half. Children 
who were heavy milk drinkers in certain areas may have been 
exposed to 100 rads or more.
    A rad, or a radiation absorbed dose, is a physical measure 
of radioactivity. For comparison, during the 1950's diagnostic 
thyroid scans used medically gave up to 300 rads of I-131.
    What do we know about radiation and thyroid cancer? Most of 
what we know is from external radiation sources, whereas the 
fallout was largely due to internal, ingested radiation. At 
external exposures of about 100 rads, there is about a seven to 
eightfold increase in the incidence of thyroid cancer. This is 
only seen for exposed children, primarily those exposed under 
age five.
    While it is virtually certain that internal exposure of I-
131 can predispose to thyroid cancer, there is much we do not 
know. We do not know the dose-response relationship. We do not 
know if the potency is the same as external radiation. If it 
is, we have estimated that these tests may have resulted in as 
many as 75,000 additional cases of thyroid cancer to the 
children alive at that time throughout the course of their 
lives, about a 20-percent increase from the expected number of 
thyroid cancers.
    Over this time, the NCI has funded several studies 
attempting to get at this issue of the relationship between I-
131 and thyroid cancer. A large study of 35,000 individuals in 
Sweden exposed to about 100 rads on average of I-131 failed to 
show a statistically significant increase in thyroid cancer.
    More directly pertinent was an NCI-funded study published 
in 1993 following a cohort of nearly 2,500 children in Utah, 
Nevada, and Arizona who had been exposed to fallout and were 
examined in the sixties and again in the 1980's. In this study 
there was a positive association between I-131 exposure and 
about a 3- to 3\1/2\-fold increased risk of thyroid cancer. As 
the authors of the study pointed out, the small number of 
cancers observed limited the certainty of the exact 
association.
    Currently the NCI is engaged in an important series of 
studies in Belarus and the Ukraine and following tens of 
thousands of children exposed to fallout doses upwards of 
thousands of rads, in radiation released during the Chernobyl 
nuclear accident. We believe that this study will provide the 
best single opportunity for establishing human dose-risk 
relations as a function of age for thyroid cancer.
    What about this study, the speed, its oversight, and the 
openness? The length of this study as far as I can tell in 
reviewing this was overwhelmingly a reflection of its 
complexity, as well as the process of review and evaluation. It 
was from its beginning overseen by an expert advisory panel 
that guided its design and progress through open public 
meetings.
    Three interim reports to Congress were prepared by NCI, in 
1984, 1986, and 1991. Progress and results were presented at 
public meetings of the NCI Board of Scientific Counselors. It 
was reported each year in the annual reports. Multiple papers 
were presented at public scientific meetings in 1987-90, 1994-
95, and publications about the study resulted from these 
presentations, including the extent and quantitation of the 
average overall exposure and the level of increased exposure to 
children.
    There is always a tension between our desire to disseminate 
and publicize the results of studies and the need to ensure the 
integrity and quality of that information through the 
scientific peer review process. That said, I believe in this 
case that a more clear, more rapid, and more aggressive plan 
for dissemination of the results to the public was called for.
    Since I became aware of the study, over the past 6 to 8 
months we have moved quickly to release the study in its 
entirety, all 100,000 pages, in a form that would be 
accessible, understandable, and useable. This plan is described 
in detail in my written statement. But a unique feature I want 
to point out is that the entire report and supporting data are 
totally accessible as of today through the Internet, an 
approach that was not even available 3 years ago.
    Despite the tremendous interest in this study, let me 
emphasize, as actually Senator Harkin has talked about in the 
newspapers, that the results confirm widely discussed and 
published ranges and extent of fallout exposure which have been 
the subject of an enormous amount of attention, including by 
the Congress, since the 1950's. This study provides, we 
believe, both important new methodologies and much more 
detailed exposure information than has been previously 
available.
    But the results ought not to be characterized as 
unexpected. This particular study was not designed to directly 
address the health consequences of these exposures. Estimates 
of additional cases of thyroid cancer, as I said, that might 
have arisen have been made, but again are subject to 
uncertainty.
    Preliminary analyses, which I can show you later, of cancer 
incidence and mortality rates across age groups have been done, 
and we have so far been not able to discern any obvious 
correlation with areas of I-131 exposure. Let me emphasize, 
however, that that does not rule out the likeliness that 
individuals exposed in the 1950's were placed at increased risk 
of thyroid cancer.
    For now, the NCI agrees with the recommendation of the 
American Thyroid Association that individuals concerned about 
their risk should consult their physicians for a manual thyroid 
exam.
    While I have emphasized the uncertainties that surround the 
health consequences of I-131 exposure, such potential 
consequences should not be trivialized. HHS has requested that 
the Institute of Medicine rapidly examine this study, how it 
was done, its validity, and other available information and 
independently report on its public health and medical 
implications.

                           PREPARED STATEMENT

    The NCI appreciates the interest and concern that you and 
the public have expressed that high quality information be 
provided about nuclear fallout. This is especially true in the 
context of the legacy of the cold war, in which such 
information was too often not provided or even hidden. We hope 
this study will contribute to our knowledge about the release 
and distribution of I-131 and how individual exposures can be 
assessed.
    I thank you for this opportunity to describe the study and 
hopefully clarify its limitations, and I'm pleased to answer 
any questions.
    Senator Specter. Thank you very much, Dr. Klausner.
    [The statement follows:]
            Prepared Statement of Richard D. Klausner, M.D.
    Good morning Senator Specter, Senator Harkin, and Members of the 
Subcommittee. I am Richard Klausner, Director of the National Cancer 
Institute (NCI), and today I am presenting to you, for the first time, 
the completed NCI report estimating thyroid doses of Iodine-131 (I-131) 
received by Americans as a result of atmospheric nuclear bomb tests 
conducted at the Nevada Test Site. This study was conducted in response 
to legislation enacted by the 97th Congress of the United States.

                               PUBLIC LAW

    Public Law 97-414, in part, directed the Secretary of the 
Department of Health and Human Services (DHHS) to conduct scientific 
research and prepare analyses necessary to develop valid and credible 
methods to estimate the thyroid doses of I-131 that are received by 
individuals from nuclear bomb fallout, and to develop valid and 
credible assessments of the exposure to I-131 that the American people 
received from the Nevada atmospheric nuclear bomb test. The magnitude, 
complexity and difficulty of such research is without precedent and the 
fact that such a study was completed is testimony to the expertise and 
commitment of a large number of government and non-government 
scientists, and particularly of two NCI researchers--Dr. Bruce Wachholz 
and Dr. Andre Bouville. The study was designed and carried out with the 
help of an Advisory Committee with representation from the fields 
relevant to radiation science. This study was not designed to evaluate 
the health effects of I-131 exposure, so such risk estimates are not 
part of this study.

                      I-131 RELEASE AND DEPOSITION

    Ninety nuclear tests released almost 99 percent of the total I-131 
entering the atmosphere from the bomb tests conducted at the NTS. These 
90 tests released about 150 million curies of I-131, mainly in the 
years 1952, 1953, 1955, and 1957. Some radio-iodine was deposited 
everywhere in the U.S., with the highest deposits immediately downwind 
of the NTS. The lowest deposits were on the west coast, upwind of the 
NTS. In the eastern part of the country, most of the deposited I-131 
was associated with rain, while in the more arid west, dry deposition 
(where particles settle on the ground) prevailed. Because I-131 has an 
8-day half-life, exposure to the released I-131 occurred primarily 
during the first two months following a test.

                          DOSE RECONSTRUCTION

    A major challenge of this study was the attempt, three to four 
decades after the events, to retrospectively assess the exposure of 
persons throughout the country. For most tests, however, it was 
possible to estimate the amounts of radioactivity deposited on the 
ground in fallout from the measurements of radioactive particles 
collected on sticky surfaces (i.e., gummed film). These collection 
units were geographically dispersed around the United States, and the 
collections were made systematically as part of an environmental 
monitoring program. These original data were re-analyzed in order to 
estimate the I-131 component in the fallout. Beginning with such 
measurements, the study used mathematical modeling of these and other 
relevant measurable data to estimate the levels of thyroid exposure in 
approximately 160 million Americans in the 48 contiguous states of the 
country during the test period. In the absence of environmental 
radiation measurements during some tests, meteorological dispersion 
models were developed to calculate the amount of fallout deposits.
    The assessments of thyroid exposure have two components: deposition 
of I-131 and the exposure of persons. First, mathematical models were 
developed to estimate the amount of I-131 deposited in each of 3,094 
counties (and sub-counties mapped in a few areas) in the contiguous 48 
States. This involved re-analysis of data from monitoring stations in 
operation across the U.S. during the testing program and the use of a 
meteorological model. This information, coupled with precipitation data 
for each county during the time the fallout clouds were over the U.S., 
permitted estimates of I-131 deposition. The dispersion of the cloud 
was tracked at four different altitudes in the days after each test to 
determine distribution of radioactive clouds. This component of the 
study was carried out in cooperation with experts from the Department 
of Energy (DoE) and from the National Oceanic and Atmospheric 
Administration (NOAA).
    Second, thyroid exposure to the U.S. population resulting from this 
fallout was assessed. It is well known that consumption of milk from 
cows grazing on contaminated pastures is the principal route by which 
I-131 is incorporated into human tissues, especially for children. Most 
of the exposure to environmental I-131 resulted from the consumption of 
this contaminated milk and, for some individuals, from the consumption 
of fresh goats' milk. This component of the study, which was carried 
out with the help of experts from the U.S. Department of Agriculture 
(USDA), involved the compilation of extensive and detailed information 
regarding pasture consumption and grazing patterns, the production of 
milk by cows, and milk distribution and consumption patterns throughout 
the country. These data were used in mathematical models to estimate 
the transfer of I-131 from deposition on the ground to the intake by 
humans of I-131 resulting from the consumption of contaminated cows' 
milk of various origins. In addition, other exposure pathways such as 
the consumption of contaminated goats' milk, eggs, leafy vegetables, 
and cottage cheese were considered as well as the inhalation of 
contaminated air.
    Finally, thyroid dose was estimated on the basis of the exposures 
that were assessed for each nuclear test and each county of the 
contiguous United States. Thyroid doses from intake of I-131 vary 
substantially as a function of age and depend mainly on the size of an 
individual's thyroid gland and on the amount of fresh cows' milk an 
individual consumed. For that reason, thyroid doses were estimated for 
13 age categories, including four in-utero ages, four for infants under 
one year of age, four for children under age 20, and adults. The 
thyroid doses to adults were estimated separately for males and for 
females. Also, because the origins of milk and the level of consumption 
vary substantially from one individual to another, thyroid doses have 
been estimated for people drinking average amounts of fresh cows' milk 
with average I-131 contamination levels from commercial sources; for 
people drinking large amounts of cows' milk with above-average I-131 
contamination levels from commercial sources; for people drinking milk 
from backyard cows; and for people drinking no cows' milk but consuming 
other foodstuffs contaminated with I-131.
    The calculation of these thyroid doses resulted in the production 
of about 100,000 pages of data and analyses that show--by county, for 
each weapons test, each series of tests, and the entire testing 
period--average levels of predicted exposure for the 13 age groups and 
for both genders, and for four milk consumption patterns. In addition, 
detailed maps have been prepared, showing the deposition pattern of I-
131 on the ground and the average thyroid doses for the population of 
each county of the contiguous United States after each weapons test and 
series of tests. The overall average thyroid dose to the approximately 
160 million people in the country during the 1950's is estimated to 
have been about 2 rad. ``Rad'' means ``radiation absorbed dose.'' It is 
a physical unit of energy deposition. To put this amount of exposure 
into perspective, routine medical use of x-rays during the 1940's and 
1950's exposed children to anywhere from 5 to several hundred rad, and 
all persons receive doses from natural background radiation of about 
0.1 rad per year.
    Because the study relied on a limited number of measurements and 
was based essentially on mathematical models, the uncertainties 
associated with the thyroid dose estimates are fairly large, usually a 
factor of three or more for averages pertaining to population groups; 
for individuals the uncertainties might be greater. However, a 
comparison of the results obtained in this study with those derived 
from the few I-131 measurements that were carried out in the 1950s, 
either in the urine or in the thyroids of people, or in cattle 
thyroids, show a reasonably good agreement.

                            PUBLIC AWARENESS

    It is important to note the context in which this study was carried 
out. What was known publicly about fallout? During the late 1950's and 
early 1960's a series of Congressional hearings were held and the 
published scientific literature was introduced into the public record. 
The preliminary results of the NCI study are remarkably consistent with 
these early reports. For example, the range of estimated I-131 exposure 
for children had previously been identified in the 1960's ranging from 
4 to 120 rad; the NCI study places ranges between zero and 100 rad. The 
results obtained in this study are also consistent with those obtained 
by the DOE and the University of Utah for populations living in states 
close to the Nevada Test Site.
    As the preliminary findings of the NCI study took form in the early 
1990's, NCI staff made a decision to prepare the data and formulae to 
be useful, accessible, and user friendly. An interactive format, now 
available on the World Wide Web, allows an individual to estimate his 
or her own exposure. By designating a state and county, and date of 
birth, users will receive a table of the estimated doses to the thyroid 
after each nuclear test. Dosages are also calculated for four different 
milk-drinking scenarios.

                            INTERIM REPORTS

    During the time period of data collection, calculation, and 
analysis, the NCI drafted status reports in 1984, 1986, and 1991 for 
transmittal to the Congress by the Secretary, HHS. The methodologies 
used in the study have been presented at scientific meetings since the 
project's inception in 1983. Meetings of the I-131 Advisory Committee, 
which was chartered in 1984 with experts in all relevant fields of 
science to assist NCI staff in carrying out this study, were open to 
the public. It served until 1993 as a place where presentations and 
discussions of the latest findings of the study and more broadly in the 
scientific arena could be aired. Updates were presented frequently to 
the NCI's Board of Scientific Counselors and in open meetings. Papers 
about the study have been presented at national and international 
scientific meetings since 1987. Since 1990, preliminary results have 
been published in the scientific literature.

                    THYROID CANCER AND RADIOACTIVITY

    Thyroid cancer is uncommon, accounting for just one percent of all 
cancers in this country. Each year about 16,000 cases are diagnosed in 
the U.S., with an estimated 1,230 deaths. Thyroid cancer is very 
curable, with the five-year survival rate at 95 percent. This type of 
cancer occurs more often in women than in men, and is seen at ages as 
young as 5. In men, incidence rises gradually with increasing age, 
leveling off after about age 70, whereas in women the increase is 
steeper, leveling off after age 30 or 35. Between 5 and 10 percent of 
cases eventually result in death, usually after age 50 and usually 
attributable to the relatively rare anaplastic and medullary forms of 
the disease.
    Scientists do not know what causes most cases of thyroid cancer. 
One known risk factor is exposure to external radiation during 
childhood. Commonly, during the 1940's and 1950's, children received x-
ray treatments to the head and neck for noncancerous conditions such as 
enlarged tonsils, enlarged thymus gland, acne, and ringworm of the 
scalp, and as a result these individuals have a higher-than-average 
risk of developing thyroid cancer many years later. A compilation of 
multiple studies has demonstrated that exposure during childhood to 100 
rads of external radiation results in a 7-8 fold increased risk of 
thyroid cancer. The vast majority of risk is seen for children who are 
exposed below the age of 10.
    While it is very likely that exposure to I-131 also increases the 
risk of thyroid cancer, there is considerable uncertainty as to the 
relative carcinogenicity of I-131 fallout exposure compared to external 
radiation. Throughout the course of the fallout study being released 
today, the NCI engaged in and funded studies attempting to evaluate the 
risk of thyroid cancer from I-131, in order to fulfill the third 
component of the legislation, which was to determine the risk of 
thyroid cancer associated with I-131 exposure.
    Thus far, studies of exposure to I-131 for medical purposes or from 
fallout in areas downwind from the site of atomic bomb tests during the 
1950's have not produced conclusive evidence that such exposure to I-
131 is linked to cancer. In 1992, the University of Utah reported a 
statistically significant dose-response relationship between exposure 
to radioiodines and occurrence of thyroid neoplasms (combined benign 
and cancerous tumors) in a group of nearly 2,500 children in Utah, 
Nevada and Arizona who had been examined in the 1960's and again in the 
1980's. However, while the correlation between the I-131 radiation dose 
and thyroid cancers alone was suggestive, it was not statistically 
significant and therefore could have been due to chance.
    The relationship between I-131 exposure and thyroid cancer 
continues to be studied. In 1985, NCI collaborated with Swedish 
scientists on a study of diagnostic I-131 received by 35,000 patients 
who received an average dose of 100 rad to the thyroid. At this mean 
dose an excess risk of thyroid cancer was seen only among persons 
referred for examination because a thyroid tumor was suspected. The 
study included 2,408 persons exposed before age 20, and 314 children 
aged 10 and under. Among persons between 15-19 years of age, two cases 
of thyroid cancer were observed compared to 1.5 cases expected. No 
cases were seen in children under age 15.
    It is perhaps too early to know, but it seems likely from 
preliminary information that thyroid cancer increased in those 
populations of Belarus, Ukraine, and Russia most affected by the 
Chernobyl accident, and that I-131 exposure is the probable cause. 
Assuming the eventual results are positive, the unresolved question 
will be how the risk from I-131 exposure compares to the risk 
associated with similar doses from x-rays. The Chernobyl nuclear 
accident provides a tragic opportunity to obtain valuable information 
needed to further develop these risk estimates. NCI staff recognized 
the value of this opportunity to address that component of Public Law 
97-414 that instructs the government to carry out research to make 
assessments of the risk of thyroid cancer from I-131. Our studies, 
supported jointly by the Department of Energy and the Nuclear 
Regulatory Commission, include about 15,000 children in Belarus and 
30,000-40,000 in Ukraine, a number of whom received doses in excess of 
1,000 rad to the thyroid. The I-131 Advisory Committee as well as the 
NCI believed that it was in the interests of the U.S., as well as the 
world community, to invest the time and effort needed over the past 
several years to accomplish the complex negotiations required to 
undertake cooperative studies of thyroid disease with scientists in 
Belarus and Ukraine.
    NCI is currently analyzing thyroid cancer incidence in our SEER 
(Surveillance, Epidemiology and End Results) Program and in nationwide 
mortality data. Preliminary analyses of these data across age groups 
have been done and we do not discern any obvious correlation with areas 
of high I-131 exposure. However, these analyses do not rule out the 
possibility that thyroid cancer risk has been elevated in exposed 
individuals and we are continuing to evaluate these data to look for 
more complicated patterns. We also are investigating the possibilities 
of conducting other studies, and expect that further discussions along 
these lines will be undertaken by the Institute of Medicine.

                              WHAT'S NEXT?

Communication plan
    Since I became aware of this study last Spring, we moved as quickly 
as possible to format and prepare the entire study for release in a 
form that was accessible and understandable. The goal of the NCI has 
been and continues to be to fully inform the public as to the results 
of research while adhering to quality control procedures to assure that 
information released is of high scientific quality and credibility.
    We have established an infrastructure to provide technical 
assistance to health care providers and health departments in 
interpreting the report (see Help Line below), and to respond to 
inquiries from patients and individuals exposed to radiation fallout, 
and to the media. We are working with the American Thyroid Association 
to provide interim education resources to physicians, patients and the 
public. We are helping state health departments interpret the report 
and respond to inquiries at the state and county level. We have 
announced through the media the availability today of the full report. 
The Cancer Information Service (CIS) has interim guidance and 
background information for all target audiences about the incidence, 
mortality and survival rates for thyroid cancer, and statistical 
information about trends in mortality, incidence, and survival in high-
exposure areas.

Dissemination plan
    NCI has announced today, through media channels, Congressional 
channels, and through state health departments:
  --the availability of the I-131 report, including appendices and 
        data, on the world wide web. The information is available at 
        the NCI web site (http://www.nci.nih.gov) and at its public, 
        patient and media sub-page (http://rex.nci.nih.gov). At either 
        site, click on ``What's New.''
  --the availability of a technical assistance helpline (1-800-273-
        7092) for health officers and health professionals. This 
        telephone number, to be operational beginning October 1, is 1-
        800-273-7092.
  --interim guidance with the American Thyroid Association for health 
        professionals on helping individuals concerned about fallout 
        exposure.
  --the availability of background information on thyroid cancer for 
        members of the public and cancer patients from the Cancer 
        Information Service at 1-800-4-CANCER (1-800-422-6237).
  --that the study's narrative report was express-mailed to state 
        health departments and other government agencies and select 
        congressional members.

Help line
    NCI has established a toll-free technical assistance helpline (1-
800-273-7092) to assist professionals in interpreting the report. We 
envision that support will be provided to health professionals such as 
public health officials, researchers, radiation epidemiologists, 
advocacy and special interest groups, and physicians and other health 
care providers. Voice mail is available for after-hours calls. Staff 
assisting with answering calls will have sufficient educational 
background and knowledge to effectively triage the calls and respond 
with credibility. We have also established a parallel system and 
procedures for responding to e-mail requests for technical assistance. 
Health officers and health professionals may send e-mail requests to 
[email protected]. Public and patient inquiries and e-mail will continue 
to be handled by the CIS. NCI staff will handle Congressional and press 
inquiries.

Institute of Medicine
    An NCI contract with the National Academy of Sciences-Institute of 
Medicine (IOM) went into effect September 30, 1997. The IOM will 
produce two substantive reports. The first, which is to be published in 
April 1998, will assess the soundness of the I-131 study's dose 
reconstruction, provide a preliminary assessment of the public health 
implications, and provide information to enable DHHS to educate and 
inform members of the public and the medical profession. The second 
report, to be published in June 1998, will develop recommendations for 
how we should address the public health implications (including 
intervention, surveillance, education and information strategies and 
clinical practice guidelines), and develop recommendations for research 
strategies that could refine risk estimates and reduce uncertainty of 
the effect of exposures.
    There have been preliminary discussions within the Administration 
about the formation of a workgroup to look at broader issues. DHHS will 
convene a meeting before the end of the year to begin the process.
    Until the IOM completes its report, we are suggesting that 
concerned individuals consult with their physician during their next 
visit. This recommendation is consistent with the position of the 
American Thyroid Association, which says that individuals who believe 
they may have been exposed to significant amounts of fallout and feel 
they are at particular risk might wish to see their physician.
Closing
    The NCI appreciates the great interest and concern that you and the 
public have that high quality and fully disclosed information be 
provided about nuclear fallout. This is especially true in the context 
of the legacy of the cold war in which such information was too often 
not provided or hidden. We hope that this study will contribute to our 
knowledge about the release and distribution of I-131 and how 
individual thyroid exposures can be assessed.
    Thank you for this opportunity to describe this NCI study and to 
clarify its limitations. I would be pleased to respond to questions.



                                Panel 1

                       NONDEPARTMENTAL WITNESSES

STATEMENT OF JOSEPH LYNN LYON, M.D., M.P.H., PROFESSOR, 
            DEPARTMENT OF FAMILY AND PREVENTIVE 
            MEDICINE, UNIVERSITY OF UTAH SCHOOL OF 
            MEDICINE
    Senator Specter. I think that our discussion may be 
facilitated if we call our expert witnesses now: Dr. Lyon, Dr. 
Beyea, Mr. Connor, Dr. McGuire. Dr. Joseph Lyon is a professor 
of family medicine at the University of Utah and was the 
principal investigator of a study in the 1980's examining the 
health impact of atomic fallout on citizens of Utah.
    Dr. Lyon, we welcome you here. The floor is yours, Dr. 
Lyon. Thank you for joining us.
    Dr. Lyon. Thank you very much, Senator Specter and ladies 
and gentlemen of the panel.
    I want to perhaps rehearse again some of the history you 
have already heard. Testing began 46 years ago this month in 
the Nevada test site. I counted at least 100 tests that were 
done above-ground, of which at least 25 distributed radiation 
well beyond the test site, we now know, as far East as the east 
coast of the United States. The most heavily affected areas 
known at that time are the two southwestern-most counties of 
Utah, containing about 10,000 people.
    There was public concern expressed starting in the mid-
fifties over the health effects, principally by scientists. 
This prompted two congressional hearings, and the result of the 
second hearing in 1959 prompted the U.S. Public Health Service 
to initiate a study to look at two of the diseases, one of 
which we have talked about today, thyroid cancer. The other was 
leukemia. The focus was on these two southwestern Utah 
counties.
    The studies, the initial studies, were carried out by Mr. 
Ed Weiss of the Public Health Service. I think it is 
instructive for the pattern that has been set by this study to 
look at these. The leukemia study found about a threefold 
excess of cancers among children who were under age 19 living 
in these two southwestern counties. That result was known by 
1964.
    The thyroid study, which Dr. Klausner has referred to 
because we carried out a second followup on that group, was 
severely limited by the fact that there was no individual doses 
on anybody. It found nothing. Now, what happened at that point 
in time was that the thyroid study was published, highlighted, 
and used to reassure the citizens of Utah of the adverse 
effects. The leukemia study was buried in the files of HHS 
after a high level meeting at the White House because of its 
impact. That study remained virtually unfollowed up and 
reassurances were offered to the citizens of Utah when 
officials knew full well that there was a hint. It was found 
exactly where they thought it would be and exactly the 
population.
    It became instructive because that is generally how the 
Federal Government responds to the issues of citizens' concern. 
That is, the negative was strongly emphasized, the positive was 
suppressed or covered up, and those who found the positive were 
frequently indicted. I do not know what this did to Weiss' 
career. He never followed up the study, nor was there any 
effort to obtain any dosimetric information.
    Senator Specter. Did you say he was indicted?
    Dr. Lyon. I say I do not know what ever happened to the 
man, but he never followed up on that study, and I think he was 
not permitted to.
    We inadvertently stumbled on Weiss' study and replicated it 
without knowing we were doing so, responding to newspaper 
accounts by a local newspaper in 1977 that there was an excess 
of leukemia. It was based on the National Cancer Institute 
atlases. I was involved with the Utah Cancer Registry at the 
time. I felt that this was an issue that kept surfacing, that 
we ought to at least look at leukemia, but I felt that the 
probability, based on the thyroid studies, was very low that 
anything would be found.
    Much to our surprise, we found about a two and a half fold 
excess of leukemias among children in the southern parts of the 
State. As I say, unknowingly we had replicated the study 
already done by the U.S. Public Health Service and long since 
suppressed.
    That finding, which was published in 1979, created intense 
controversy, as you can imagine. Efforts to follow up, that is 
obtain funding, to try to obtain better dosimetry, to try to 
obtain larger samples, thrust us into a political situation 
that even the President of the United States at that time was 
not able to, on his guarantee, to get us funding. It finally 
took the personal intervention of Orrin Hatch, using a great 
deal of clout.
    The funding came to us in three hunks of money: one-third 
from NCI, two-thirds from DOE and DOD. That study, which ran 
for about 8 years, was essentially heavily influenced by both 
of those Departments.
    There were several things that came out of that study from 
a scientific standpoint. First, we confirmed the leukemia 
findings for the southern portions of the State and placed 
dosimetry estimates on them. We also confirmed that, as Dr. 
Klausner has mentioned, there was about a three and a half fold 
excess of thyroid neoplasms in these school kids that had been 
previously examined in the mid-sixties.
    There were enough scientific findings to suggest that there 
were adverse health effects. What happened personally and at a 
political level was much different. Let me give you a couple of 
examples.
    We found excess leukemias that extended into northern Utah, 
where there are a much larger number of people, where you have 
got about 80 percent of our population. The site visit 
committee with the Department of Energy and Department of 
Defense representatives very busily revised all the dose 
estimates downward for northern Utah after they saw the study 
findings. Now, this is generally something that graduate school 
students are failed out of graduate school for, but the Federal 
Government was able to get away with it. So the finding was 
confined to southern Utah.
    When the study was slated for publication in the Journal of 
the American Medical Association, someone at NCI or DOD or DOE 
leaked the results to the local newspaper with the statement 
the findings were inconclusive and did not support the earlier 
associations. We were embargoed by the journal and could not 
respond to those criticisms. My colleagues still to this day 
who didn't read the study console me for the fact that I have a 
negative study. I have to ask them to go and read the findings 
and suggest that a sevenfold excess of leukemia is not a 
negative study.
    The third thing that Dr. Klausner may not have been aware 
of is that the small numbers of the thyroid cohort study that 
so concerned us also, prompted us to submit a grant to the 
National Cancer Institute or to the NIH for followup. It was 
approved and funded. Someone at the NCI intervened with the 
Board of Scientific Counselors to make sure that the funding 
was not available. We were thrown around between various 
agencies, with the grant finally assigned to the National 
Institute of Digestive and Kidney Disease--a very strange 
place.
    We were never given the ability to respond to any of the 
criticisms which were made of that application after it had 
been approved and funded.
    Senator Harkin. What year was that?
    Dr. Lyon. That happened in 1989. We have been trying to 
fund that study for followup. The study needs more--we know the 
people, we know their doses. We have not been able to obtain 
any Federal funding to follow these people.
    I think the handling of the studies is indicative, or at 
least it seems to me indicative, of some of the behavior we 
have seen with this NCI study: essentially, accentuate the 
negative; if the negative looks too threatening, do not publish 
it.
    I guess in conclusion I would simply say that, given the 
long and rather unfortunate history of the behavior on the part 
of many Federal officials, I think studies of this nature need 
to be assigned to an agency that has a strong public health 
interest and that has substantial public involvement. There was 
no public involvement in any of the studies we were involved 
in. We had attempted to get a public group set up and basically 
the advisory committee told us to not do so. I think it needs 
to be placed in agencies.
    In conclusion, I would have to say that if the NCI were to 
call me tomorrow and say, Dr. Lyon, we will fund your thyroid 
study, I would say: If it is at the NCI under the current 
administration, I would really prefer to pursue my career in 
other areas.
    Senator Harkin. Prefer what?

                           PREPARED STATEMENT

    Dr. Lyon. I would prefer to pursue research in other areas, 
simply because I do not think that the current administration 
is particularly interested. And we have already had ample--I 
have already experienced ample problems with trying to carry 
out research on this topic with a less than friendly Federal 
Government, particularly within the scientific establishment.
    [The statement follows:]
           Prepared Statement of Joseph L. Lyon, M.D., M.P.H.
    Good morning, I am Joseph L. Lyon. I am a full professor in the 
Department of Family and Preventive Medicine, University of Utah School 
of Medicine, Salt Lake City, Utah. I received my M.D. degree from the 
University of Utah, and a Master of Public Health degree from Harvard 
University. My professional research interests are in the causes of 
diseases in human populations, and I am a chronic disease 
epidemiologist. I am appearing before this committee to testify on the 
health effects that arose from above ground nuclear testing at the 
Nevada Test Site (NTS) between 1951-1958 and its relationship to the 
recently released report by the NCI of extensive contamination of large 
areas of the United States by radioactive iodine generated by these 
tests. I shall comment on the activities of the U.S. Government also 
through its' various agencies to inform the public about the health 
risks associated with fallout from above ground nuclear testing at the 
NTS. This is the fourth time I have appeared before committees of the 
United States Senate investigating the cancers believed to be caused by 
U.S. above ground nuclear weapons testing.
    Between 1951-1958 the U.S. Atomic Energy Commission detonated over 
100 nuclear weapons at its test site in the Nevada desert. At least 25 
of these detonations produced measurable radioactive fallout in 
populated areas of Utah and states further north and east. One test in 
particular, Shot Harry, detonated about 5:15 a.m. on the morning of May 
19, 1953, accounted for about 80 percent of the total radiation 
deposited in southwestern Utah.
    There were concerns among the public and scientists about the 
increased risk of cancer to the Utah population from radioactive 
fallout, but these were generally ignored. These concerns led to a 
Congressional hearing in 1959. There was no evidence of any health 
problems, but no studies of the people most heavily exposed had been 
done. However, because of potential health concerns, the U.S. 
Government decided to move all further nuclear testing underground.
History of a cover-up
    In 1960 the Federal Government, responding to the health concerns 
raised by the 1959 Congressional hearings, began two studies in Utah of 
cancers associated with radioactive fallout. These studies were limited 
to the southwestern most counties in Utah, Washington, and Iron 
Counties, and an adjacent county in western Nevada. The diseases chosen 
for study were leukemia and thyroid neoplasms. It was already well 
established that exposure to gamma radiation could cause an increase in 
leukemia mortality, and there was concern that the radioactive iodine 
generated by a nuclear detonation would enter the food chain via milk 
and expose the thyroid gland.
    The U.S. Public Health Service investigated leukemia deaths between 
1950-1964 in the two Utah counties closest to the NTS and found a 3.29 
fold excess among those under age 19, and a 1.5 increased risk of 
leukemia for citizens of all ages. No effort was made by the principal 
investigator, Mr. Edward Weiss of the U.S. Public Health Service, to 
link the extensive data gathered by the AEC on radiation doses received 
by citizens of the two Utah counties to the location of the individual 
children who died to determine if the excess leukemia deaths might be 
related to radioactive exposure from the NTS. This would have been the 
next step to determine if radioactive fallout was the cause of the 
excess leukemia in southwestern Utah, but this was not done nor was it 
even discussed in the written report of the study.
    The study findings were written up in the form of a scientific 
paper by Weiss and given to his superiors for their approval before 
submission to a scientific journal. The manuscript was circulated 
within the U.S. Public Health Service and the Atomic Energy Commission. 
It was severely criticized as to the study size and choice of control 
group. There was some division of opinion among the public health 
officials who wanted the findings published and atomic energy officials 
who did not. This was resolved at a 1965 meeting at the White House 
presided over by the President's Scientific Advisor. The decision was 
made not to publish the paper because the study was based on a small 
number of deaths, and the officials of the Atomic Energy Commission did 
not wish to unduly alarm the public with alarming but inconclusive 
findings. Implicit in this decision to stop publication of the first 
evidence of an association between fallout from above ground weapons 
testing and leukemia was the impact such a finding might have on the 
U.S. Government's continued nuclear weapons testing program.
    The written reasons given for blocking publication of Weiss's 
leukemia study were problems in study design and interpretation of 
results. Rather than trying to correct these problems by adding more 
years of observation, obtaining a local control group, and linking 
radiation exposure by individual deaths, nothing more was done. The 
decision to do nothing to follow up after finding excess leukemia 
deaths among young people living in the two Utah counties that were 
known to have been most heavily exposed to NTS was even more 
reprehensible than the decision to suppress the original paper. It 
meant that every Government official thereafter who offered 
reassurances to the people of Utah that there had been no cancers 
caused by radiation was knowingly or unknowingly lying to the public.
    An interesting sidelight to this episode did occur. The U.S. 
Centers for Disease Control was contacted by someone in the Public 
Health Service and asked to investigate the excess leukemia deaths in 
southwestern Utah to determine if they might have been caused by an 
infectious agent. The CDC investigators were never informed that the 
children who died of leukemia had received substantial exposure to 
radiation from the NTS, and so no information was obtained during the 
CDC investigation about the radiation exposure the dead children had. 
Not surprisingly no cause for the excess leukemia deaths was found. The 
hypothesis that an unknown infectious agent can cause leukemia 
clusters, an idea popular in the 1960's, has not been substantiated by 
further research, but exposing the children of a county to 5+ rads of 
gamma radiation will cause extra leukemia deaths to appear within a few 
years.
    The second study of the carcinogenic effects of radioactive fallout 
was conducted by the U.S. Public Health Service to determine if the 
radioactive fallout had increased thyroid cancer rates among children 
in southwestern Utah. About 3,000 school children living in the fallout 
contaminated areas of Western Nevada and southwestern Utah (White Pine 
County, Nevada and Washington County, Utah), and a control group of 
2,000 children living in southern Arizona were identified and examined 
for thyroid neoplasms.
    This study was well designed and conducted. But despite suggestions 
by internal and outside consultants, no information about the source 
and amounts of fresh cow's milk that each child had drunk during above 
ground testing at the NTS, the principle route of exposure to the 
thyroid gland, was obtained. This made it impossible to assign a 
radiation dose to any of the children. An error of this magnitude in an 
epidemiologic study is simply not possible by chance. It is comparable 
to conducting a study of lung cancer without asking about cigarette 
smoking. Given this astonishing error, the study found no excess 
cancers of the thyroid gland. Thereafter, the negative findings from 
this study were often cited to reassure the public that no cancers had 
resulted from above ground nuclear testing.
    Both of these scientific studies commissioned by the U.S. 
Government to determine if there were cancers associated with 
radioactive fallout from the NTS failed to meet minimal criteria for an 
epidemiolgic study, i.e., measure the exposure and determine if it's 
related to a disease, by failing to measure exposure. Despite this 
serious flaw, one of the studies found evidence that weapons testing 
fallout had caused excess leukemia deaths in Utah. This politically 
explosive finding was dealt with by a cover-up, while the study that 
found no effect was publicized to reassure the citizens of Utah that 
there were no cancers caused by fallout from the Nevada Test Site.
    The basic pattern of how to deal with any scientific study that 
might suggest that NTS fallout had caused cancer was determined for 
future generations by Federal bureaucrats through their handling of 
these two studies. The principles were as follows: suppress any data 
that suggests a positive association between exposure and subsequent 
cancer and mask your motives by stating that you do not want to unduly 
alarm the people who were exposed. Cite only studies that found no 
association to reassure people that their health concerns are 
groundless. And finally, do everything possible to make sure that no 
further scientific studies will be done that might contradict your 
position.
    In February 1979, responding to a newspaper article that reported 
an excess of leukemia deaths in southwestern Utah, three other 
colleagues and I published in the New England Journal of Medicine a 
study of the association between childhood leukemias and radioactive 
fallout generated from the detonation of nuclear weapons at the Nevada 
Test Site. Children born in southern Utah between 1951-1958 experienced 
2.44 more leukemia deaths compared to children born before and after 
above ground bomb testing.
    Unknowingly we had replicated and expanded the findings from the 
earlier, unpublished study by the U.S. Public Health Service. The 
publication of this paper immediately made us the focus of an intense 
effort by the Federal Government to disprove our findings. University 
employed scientists complain that industry hire scientists to refute 
their findings when the findings might adversely impact the industry. 
Let me assure you that when the Federal Government is the polluter, it 
follows exactly the same strategy as any company. But the Federal 
Government has far greater resources and power than are available to 
companies. For example, our study was reanalyzed four times at 
substantially more cost than was spent on the original study.
    The publication of this study and the subsequent lawsuit filed by 
citizens living in Washington County, Utah refocused attention on the 
carcinogenic effects that have resulted from the fallout clouds 
generated by above ground testing at the Nevada Test Site. The 
Department of Energy not only continued to deny that any cancers had 
resulted from the testing, but also set out to determine the extent of 
contamination of Utah and the rest of the United States by the 
radioactive fallout clouds. Crude measurements of fallout had been made 
at widely dispersed monitoring stations across the U.S. but had never 
been summarized or analyzed. It was the summarization and 
computerization of these records that provided the dose estimates for 
the study recently released by the NCI.
Re-examining the effects of fallout on Utah 1982-91
    The findings from our 1979 leukemia study prompted a re-examination 
of the potential adverse health effects that might have been caused by 
exposure of the citizens of southwestern Utah to radioactive fallout 
from the Nevada Test Site. My colleagues and I at the University of 
Utah were funded in 1982 through the National Cancer Institute to 
determine if the excess leukemia deaths in southwestern Utah reported 
by us (and previously by Weiss of the U.S. Public Health Service) were 
really related to radioactive fallout from the NTS. We were funded also 
to locate the children previously examined for thyroid cancer and re-
examine them. We were to estimate a radiation dose to the thyroid gland 
for each study subject. Our funding was administered by the NCI, but 
two thirds came from the Departments of Energy and Defense, and these 
agencies, via regular sites visits, exerted substantial influence on 
our study's design, progress, and final interpretation of our results.
    We published our findings for leukemia deaths in the Journal of the 
American Medical Association in the July 31, 1990 issue (copy 
attached). We found a 7.82 fold excess of leukemia deaths among those 
less than age 19 who were living in southwestern Utah during the period 
of above ground nuclear testing.
    The public impact of this article was diminished when some of the 
study findings were leaked a week prior to its publication date to a 
newspaper reporter by someone at NCI, DOE or DOD with whom we had 
shared the final manuscript of the article. The ``spin'' given by the 
leaker was that the study findings were inconclusive and could not 
confirm the earlier studies by Weiss, and my colleagues, and I. Since 
our article was embargoed by the journal until the day of publication, 
we could not respond to the media. We once again see the principles I 
mentioned above being applied. When you can't suppress findings of 
adverse effects from NTS fallout, publicly label the results as 
inconclusive, knowing full well that the investigators cannot counter 
your ``spin''.
    Using estimates of radiation exposure to 57 Utah communities 
provided by the U.S. Department of Energy and published in the journal, 
Science, in January 1984, we found a statistically significant excess 
of leukemia deaths in northern Utah also. But when these findings were 
shared with the Department of Energy representatives on our site visit 
committee, the published radiation exposure estimates were revised We 
were informed that this revision was based on classified data. The 
radiation exposure to northern Utah from the NTS was decreased by 
assigning more of it to exposure from Russian nuclear testing. This 
caused the association of leukemia with NTS fallout in northern Utah to 
become non-significant. We were denied access to the classified data 
that was used to make this dose reassessment, and the Department of 
Energy never amended or retracted their original study of NTS radiation 
exposure published in Science.
    We published our findings on thyroid disease and fallout in the 
November 3, 1993 issue of the Journal of the American Medical 
Association (copy attached). We found a three fold excess of thyroid 
neoplasms among those with the heaviest exposures to NTS generated 
radioactive iodines. The small number of neoplasms we found (18 
neoplasms of which 8 were carcinomas) means the findings must be 
interpreted with some caution. We did not view the results as 
inconclusive because as the amount of radiation increased the number of 
neoplasms increased, and the number of neoplasm produced per unit of 
radiation agrees with other studies of radiation and thyroid cancer.
    Our finding, though based on a small number of new cases, was the 
first to suggest that normal individuals who were exposed as children 
to environmental contamination from radioactive iodines are at higher 
risk of developing thyroid neoplasms. It cost us about $3 million to 
estimate a dose of radiation to the thyroid gland of these subjects. 
Most of the cost came from the need to identify and interview the 
mothers of the study subjects about their children's milk drinking 
habits from birth until age 18 and identifying and interviewing all 
dairy farmers and milk processors in southwestern Utah.
    Because of the importance of our finding of an excess of thyroid 
neoplasms from radioiodine released into the atmosphere from nuclear 
events to scientists studying similar exposures, in October 1987 we 
submitted a grant application to the National Institutes of Health to 
fund another cycle of examination of the former school children. This 
request was prompted by the small number of neoplasms we identified and 
the fact that a few more years of follow-up would resolve this problem. 
It was prompted also by the fact that our subjects were just reaching 
the highest risk period for the development of thyroid cancer, age 40 
and above. The application was assigned to the National Institute of 
Environmental Health Sciences, reviewed, and received a fundable 
priority score. But the Board of Scientific Counselors at NIEHS 
declined to fund the application (see the letter dated February 28, 
1989). We were never given an opportunity to respond to the Board's 
concerns were told the application had been reassigned to the National 
Institute of Diabetes, Digestive, and Kidney Diseases. We were told 
informally that our project officer for the 1982 NCI study, Dr. Bruce 
Wachholz, had requested that the Board take this action. While I cannot 
confirm Dr. Wachholz's intervention, the Board members had detailed 
information about the administration, methods, and findings of our 
study which were not provided by us. We submitted the application again 
in 1991 to the NIH. The priority score was below the funding line, and 
so no further follow-up of this group has occurred despite repeated 
appeals to the Federal Government by me and the Utah Congressional 
delegation for funding.
    Once again we see the principles I mentioned above being applied. 
When positive findings occur, label the findings as inconclusive, and 
make sure that no further work is done to strengthen the findings.
Comments on the NCI iodine study
    The release of the NCI report on radioactive iodine exposure of 
people outside Washington County, Utah has once again raised scientific 
and political interest in the findings of our thyroid study. 
Reassurances were offered to the public in the press release put out by 
the NCI that the Utah thyroid study findings were ``inconclusive''. The 
use of the term ``inconclusive'' to describe our thyroid study is 
disingenuous. We found a three fold increased risk between childhood 
exposure to radioactive iodine and subsequent thyroid neoplasms with a 
clear dose response relationship. Certainly no researcher would 
consider exposing a group of children to radioactive iodine based on 
such a finding. The only thing inconclusive about our study was the 
small number of neoplasms detected, and we had proposed to remedy this 
weakness in 1988 by adding another five years of follow-up, but had 
been denied funding by the Federal Government.
    I cannot understand why the findings from the NCI report were 
delayed for so long. There have been prior studies of the distribution 
of radioactive iodine from above ground weapons testing suggesting 
extensive contamination outside of Utah, and a colleague at the 
University of Utah, Dr. Victor Archer, reported an association between 
NTS generated fallout and thyroid cancer in states remote from Utah in 
the journal, Archives of Environmental Health, September/October 1987. 
The findings from the NCI thyroid study were being discussed among 
radiation researchers five years ago, yet no one had the power to force 
the publication of the release until the press intervened this July.
    After the NCI study completion in 1992 and as it was being edited, 
there were no efforts by staff at the NCI to fund another cycle of 
thyroid examination of the Utah thyroid group, though they are unique 
in the world from a scientific standpoint: the only group of young 
children accidently exposed to radioactive iodine with calculated 
radiation doses to their thyroid glands and data from two cycles of 
physical examinations spanning 30 years. Instead, the findings were 
labeled as ``inconclusive''. The findings were offered to reassure the 
public at the August 1, 1997 NCI press conference. This followed the 
same pattern as the 1966-70 report on this same group when reassurance 
was provided to the citizens of Utah that there was no need for concern 
over radioactive fallout.
    I contrast handling the NCI study with recent reports of increased 
risk of pulmonary hypertension and heart valve damage from combination 
drug therapy for obesity commonly referred to as the phen/fen diet. 
Based on what would be labeled as ``highly inconclusive'' evidence, the 
manufacturer withdrew the drugs from the market and took steps to set 
up medical surveillance of those who might have been affected. If phen/
fen was being marketed by the Federal Government, what would have been 
the Government's action? Surely there is little question that ingestion 
of radioactive iodine can damage and destroy the thyroid gland. Yet, to 
this day there is no medical surveillance of the heavily exposed 
population of southwestern Utah. And officials of the Federal 
Government have never met with these citizens to inform them of their 
potential risk of thyroid cancer.
    Finally, I believe that many of the problems I have detailed here 
concerning the Federal Government's handling of the adverse health 
effects from radioactive fallout could have been prevented had the 
Federal Agencies handling these problems been willing to appoint and 
work with committee-based citizens' groups. These groups need to be 
involved at the initiation of any such study and be kept fully informed 
of the study's progress and findings. Such has not been the case in any 
of the studies of radiation carried out by the U.S. Public Health 
Service in Utah between 1961-70 and the NCI funded study carried out 
between 1982-91.

Conclusions
    The adverse health effects associated with the release of 
radioactive chemicals from the NTS have been a cause of public concern 
for at least 40 years, prompting at least six previous Congressional 
hearings. The responsible Federal agencies have consistently responded 
to the public's concern with evasion, deceit, and cover-up garbed in 
the cloak of scientific objectivity. They have expressed a desire to 
obtain the truth so that wise decisions could be made, while all the 
time trying to suppress or stop any scientific study that might confirm 
the public's fears. When these tactics failed, the Federal officials 
labeled any study that suggested cancer or leukemia might be associated 
with fallout as ``inconclusive''. Much of this behavior was justified 
by these officials the grounds of national security considerations, but 
those considerations surely evaporated by 1991.
    I was appalled to find that employees of one of the premier 
research institutions in the world, the National Cancer Institute, in 
August 1997, were using the same tactics that have been used for the 
last forty years by officials from other Federal Agencies. Even more 
upsetting to me was that these tactics had been used to obfuscate their 
own research findings of potential excess risk of thyroid cancer for 
many citizens of the U.S. Do these scientists not believe their own 
research? I was also upset and angry that our study of thyroid disease 
in Utah was being used to reassure people that the association between 
exposure to fallout generated radioactive iodine and thyroid cancer was 
``inconclusive''. I had hoped that by 1997, employees of the Federal 
Government involved with the important public health issues of 
radioactive contamination of U.S. citizens by the actions of the U.S. 
Government had reached a point where candor and honesty were foundation 
principles in dealing with the public. This was not the case at the NCI 
in its handling and the recent radioactive iodine study and it saddens 
me.
    The credibility of the Department of Energy has been so severely 
compromised by their handling of the adverse health effects of 
radioactive materials that in 1992, all health related research with 
the DOE was transferred to the Centers for Disease Control and 
Prevention. I am a member of the Secretary of Health and Human Services 
Advisory Committee for Energy Related Research that has monitored this 
transfer. The attitude and behavior of the Federal employees within the 
CDCP who are taking over these radiation related research programs is 
in stark contrast to that exhibited by those at the NCI. The CDC 
insists on citizen and/or worker involvement from the outset in every 
study. For example, in the study of thyroid cancer in the citizens 
around the Hanford reactor, the Federal project officer has 
scrupulously avoided knowing any of the study findings so as not to 
bias his administrative actions. Based on my observations of operating 
procedures and scientific integrity of the radiation epidemiology 
branch of the CDCP, I would recommend that all research within the 
Federal Government that involves the effects of radioactive fallout on 
human populations be placed under the control of the U.S. Centers for 
Disease Control and Prevention. I would not be willing to accept a 
grant to conduct another round of thyroid examinations on our Utah 
study group if the administration of the funds was handled by the 
current radiation staff at the NCI.
                                 ______
                                 

 [From the Journal of the American Medical Association, Nov. 3, 1993, 
                       vol. 270, pages 2076-2082]

 A Cohort Study of Thyroid Disease in Relation to Fallout From Nuclear 
                            Weapons Testing

(Richard A. Kerber, Ph.D.; John E. Till, Ph.D.; Steven L. Simon, Ph.D.; 
 Joseph L. Lyon, M.D., M.P.H.; Duncan C. Thomas, Ph.D.; Susan Preston-
 Martin, Ph.D.; Marvin L. Rallison, M.D.; Ray D. Lloyd, Ph.D.; Walter 
                            Stevens, Ph.D.)

    Objective.--To estimate individual radiation doses and current 
thyroid disease status for a previously identified cohort of 4,818 
schoolchildren potentially exposed to fallout from detonations of 
nuclear devices at the Nevada Test Site between 1951 and 1958.
    Design.--Cohort analytic study.
    Setting.--Communities in southwestern Utah, southeastern Nevada, 
and southeastern Arizona.
    Participants.--Individuals who were still residing in the three-
state area (n=3122) were reexamined in 1985 and 1986, and information 
on the subjects' and their mothers' milk and vegetable consumption 
during the fallout period was obtained by telephone interview (n=3545). 
After exclusions to eliminate missing data and confounding factors, 
2,473 subjects were available for analysis.
    Main outcome measures.--Individual radiation doses to the thyroid 
were estimated by combining consumption data with radionuclide 
deposition rates provided by the U.S. Department of Energy and a survey 
of milk producers. Relative risk models adjusted for age, sex, and 
state were fitted using maximum likelihood to period prevalence data 
for thyroid carcinomas, neoplasms, and nodules.
    Results.--Doses ranged from 0 mGy to 4600 mGy, and averaged 170 mGy 
in Utah. There was a statistically significant excess of thyroid 
neoplasms (benign and malignant; n=19), with an increase in excess 
relative risk of 0.7 percent per milligray. A relative risk for thyroid 
neoplasms of 3.4 was observed among 169 subjects exposed to doses 
greater than 400 mGy. Positive but nonsignificant dose-response slopes 
were found for carcinomas and nodules.
    Conclusions.--Exposure to Nevada Test Site--generated radioiodines 
was associated with an excess of thyroid neoplasms. The conclusions are 
limited by the small number of exposed individuals and the low 
incidence of thyroid neoplasms.
                                 ______
                                 

 [From the Journal of the American Medical Association, Aug. 1, 1990, 
                        vol. 264, pages 585-591]

   Leukemia in Utah and Radioactive Fallout From the Nevada Test Site
                          a case-control study

(Walter Stevens,. Ph.D.; Duncan C. Thomas. Ph.D.; Joseph L. Lyon. M.D. 
M.P.H.; John E. Till, Ph.D.; Richard A. Kerber, Ph.D.; Steven L. Simon. 
   Ph.D.; Ray D. Lloyd, Ph.D.; Naima Abd Elghany, M.D. Ph.D.; Susan 
                         Preston-Martin, Ph.D.)

    Previous studies reported an association between leukemia rates and 
amounts of fallout in southwestern Utah from nuclear tests (1952 to 
1958), but individual radiation exposures were unavailable. Therefore, 
a case-control study with 1,177 individuals who died of leukemia and 
5,330 other deaths (controls) was conducted using estimates of dose to 
bone marrow computed from fallout deposition rates and subjects' 
residence locations. A weak association between bone marrow dose and 
all types of leukemia, all ages, and all time periods after exposure 
was found. This overall trend was not statistically significant, but 
significant trends in excess risk were found in subgroups defined by 
cell type, age, and time after exposure. The greatest excess risk was 
found in those individuals in the high-dose group with acute leukemia 
who were younger than 20 years at exposure and who died before 1964. 
These results are consistent with previous studies and with risk 
estimates for other populations exposed to radiation.

                          NO FUNDING FOR STUDY

    Senator Harkin. Have you ever applied to the Centers for 
Disease Control?
    Dr. Lyon. We have approached them. They are interested in 
carrying out the study, but have no funding for it, Senator.
    Senator Specter. Dr. Lyon, we may not get to all the 
details in the questions and answers, but to the extent you 
have a suggestion as to what agency ought to do the research 
and what kind of funding is necessary, this is something that 
we might even be able to accommodate at this late date on our 
conference report.
    Dr. Lyon. We have a request for about $1.9 million in that 
Senator Bennett has made.
    Senator Specter. $1.9 million?
    Dr. Lyon. $1.9 million per year for the next 5 years.
    Senator Specter. That might be accommodated in a $79 
billion budget.
    Dr. Lyon. That also I believe covers research on the Indian 
groups in Nevada also.
    Senator Reid. Who does he recommend do it?
    Dr. Lyon. I would suggest the Centers for Disease Control, 
because of their long involvement with public health and with 
public involvement in their research process.
    Senator Specter. Let us move ahead now to Dr. Beyea.
    Senator Harkin. I just want to say one thing for the 
record, Mr. Chairman. I am with you on that, but I want to make 
sure that any grant application that comes in does go through 
the rigorous peer review process that has been established.
    Dr. Lyon. Well, we survived that once, Senator.
STATEMENT OF JAN BEYEA, Ph.D., SENIOR SCIENTIST, 
            CONSULTING IN THE PUBLIC INTEREST
ACCOMPANIED BY LAWRENCE MAYER, M.D., BIOSTATISTICIAN AND CLINICAL 
            INVESTIGATOR, JOHNS HOPKINS AND ARIZONA STATE UNIVERSITIES

                           SUMMARY STATEMENT

    Senator Specter. Our next witness is Dr. Jan Beyea, a 
senior scientist at the firm Consulting in the Public Interest. 
Dr. Beyea has written extensively on the radiation health 
effects of Three Mile Island and other nuclear incidents. We 
thank you for coming and look forward to your testimony.
    Dr. Beyea. Thank you, Senators. I have asked Dr. Lawrence 
Mayer, who is a biostatistician and clinical investigator at 
Johns Hopkins and Arizona State University, to come in case 
there are any questions to answer. He has also generously 
agreed to hold up a poster here that I am going to show you in 
a minute, if I could.
    I have only a few points to make. First of all, as a dose 
reconstructionist I think that the numbers in the NCI report 
are somewhat understated.
    Senator Reid. As a what? I could not understand.
    Dr. Beyea. A dose reconstructionist, one who does the same 
kind of work as done by the NCI researchers.
    I think the numbers are probably understated to a certain 
extent to make the things look a little better.
    My second major point has to do with the actual health 
effects. If I could have that poster, Dr. Mayer.
    Dr. Mayer and I have both researched the world's literature 
on thyroid effects, and what we are concerned about is that 
attention has focused almost exclusively on cancer and there 
are a number of other health effects that are probably more 
likely to have occurred in the population than thyroid cancer.
    What I have done here is I have listed under the first 
column various cancer diseases, those which were mentioned in 
the NCI report, when it was known scientifically when these 
health effects would occur, and finally what the lowest dose 
that has been confirmed in the literature. These numbers do not 
mean that these effects cannot occur lower than that, but these 
have been confirmed in the literature at these doses.
    So we go over to cancer. That has been well discussed. But 
nodularity, a lesser degree, which includes cancer, includes 
adenomas. Sometimes these have to be surgically removed. You 
are going to find more nodules than you are going to find 
cancer.
    Autoimmune thyroid disease includes hypothyroidism, chronic 
thyroiditis. These are diseases that are relatively mild, but 
they are still important. They are more likely to occur than 
cancer. The most likely way they are occurring at low dose 
radiation is through the autoimmune process, a process where 
the radiation triggers in the body our own immune system and 
our own immune system begins to attack our thyroid cells and, 
after many, many years, causes thyroid disease.
    In fact, these effects didn't show up in the A-bomb 
survivors until 40 years after the bomb was dropped, which 
means that these should just now begin to be showing up in the 
population that was exposed in the fifties and sixties in the 
United States.
    This was all known. It has been known for many years now. 
And I do hope, and Dr. Klausner assures me, that this now will 
be looked at by the Institute of Medicine. But I do hope you in 
this panel in front of us will also make some attempt to make 
sure that this is considered in the assessment of what is done 
as a follow-up to this.
    It is my belief and Dr. Mayer's belief, having looked at 
this, that we really do need a medical surveillance program 
that will allow doctors to be acquainted with this effect, 
which is fairly new, to look for these. It involves thyroid 
scans and also some blood tests, the additional medical tests 
that you would do to find these autoimmune thyroid diseases.
    Senator Harkin. May I just interject, Dr. Beyea?
    Dr. Beyea. Yes, please do.
    Senator Harkin. The autoimmune thyroid disease, you just 
said the lowest dose confirmed. What does that mean? Explain 
that again, please?
    Dr. Beyea. It means that at Chernobyl, for instance, there 
were thousands of children who were irradiated. At 15 rads of 
exposure, the population is showing excess elevated thyroid 
antibodies, which are an indication that the autoimmune process 
has started, has begun in those children, and that years later 
they will develop, some of them, a fraction of them will 
develop, hypothyroidism.
    Now, not every scientist agrees with this, by the way. 
There is some debate in the scientific literature about this. 
But it is certainly something that needs to be considered in 
any medical surveillance program. It is cheap to look for. It 
is easy to find and it should be part of the process.
    There is another study that was done in 1988 by Kaplan that 
showed between 10 and 112 rads there was a doubling in this 
kind of process. Nagataki did a study in 1994 at Hiroshima--at 
Nagasaki, which showed an increase, a doubling increase in this 
kind of disease in the atom bomb survivors at about 40 rads.
    So the literature show somewhere between this range is 
perhaps where you start, where you start looking for it.
    Senator Harkin. So what you are saying is that the NCI 
report looked just at cancer.
    Dr. Beyea. That is right.
    Senator Harkin. And that they did not look at nodularity or 
autoimmune thyroidism?
    Dr. Beyea. Let me clarify. In the materials--I see Dr. 
Klausner shaking his head here. In the materials that have been 
circulated about this report, there has been only mention of 
cancer that I could find. There has been no mention that there 
is likely three times as much adenomas. There has been no 
mention of low dose autoimmune thyroid disorder.
    Senator Specter. Dr. Klausner, you have shaken your head 
no. We will give you a chance right now for a 1-minute response 
to that.
    Dr. Klausner. It is just that this particular report is 
only looking at dose estimates and exposure estimates. As I 
said, this report does not talk about thyroid cancer.
    Dr. Beyea. But the materials you circulated, but the 
material you circulated, in which you described, and I think 
very rightly--you did a good job in talking about the issues of 
thyroid cancer and that is naturally what most people focus on. 
But my suggestion is that in future documents that you also 
consider these other nodularities and autoimmune thyroid 
conditions.
    Senator Specter. Is Dr. Beyea right about that, Dr. 
Klausner?
    Dr. Klausner. Whether that in the future we ought to look 
at these things? We have not limited the Institute of Medicine 
in what they are looking at in terms of health consequences as 
well as in terms of thyroid consequences.
    Senator Specter. You have not limited it, but would you ask 
them to include what Dr. Beyea has said?
    Dr. Klausner. We are happy to do that, but we have asked 
them to look at all health consequences.
    Senator Specter. We will pick this up later in the 
questions and answers. Dr. Beyea, you have some more to say?
    Dr. Beyea. I have a quick conclusion, just a quick 
conclusion. I would like to suggest that it is very important 
that we look at what happened and why things maybe were a 
little slow, but it is also important that we think about 
taking action. That involves a medical surveillance program, 
giving information to citizens as to what early science might 
be of various kinds of diseases.

                           PREPARED STATEMENT

    Finally, I think we have to be prepared to give medical 
treatment to those areas where people are not adequately 
protected by medical insurance.
    [The statement follows:]

               Prepared Statement of Jan Beyea, Ph.D. [1]

    I have asked Dr. Lawrence Mayer [2] to accompany me here 
today to answer any medical questions related to the work I 
will be discussing. For this hearing, I reviewed the NCI's 
exposure calculations based on the preliminary information 
published by NCI on its study, [3] as well as other uses of the 
databases relied upon by NCI. [4] In connection with litigation 
over radioiodine releases from the Hanford production facility, 
Dr. Mayer and I have also reviewed the scientific literature on 
the health effects associated with low-dose exposure to 
radioiodine, which has made us sensitive to disease risks other 
than thyroid cancer.
    Since NCI in its preliminary reports has only discussed the 
possible connection between radioiodine exposure and thyroid 
cancer, I will focus most of my attention on thyroid nodules 
and autoimmune thyroid diseases. Based on my studies and those 
by Dr. Mayer, I have reached a number of conclusions:
    1. The ``gummed paper'' data, which NCI used to calibrate 
its estimates of radioiodine exposure, are probably free from 
the political pressures of the time and, therefore, can be used 
as the basis for unbiased exposure estimates.
    DOE's Health and Safety Lab (HASL, now EML), an institution 
that has always prided itself on its independence and 
integrity, carried out the measurements of fallout 
radioactivity on gummed paper at the time. Having been privy to 
EML practices as part of discovery in legal cases, [5] I have 
seen evidence of HASL scientists resisting orders to suppress 
information, finding ways to make the information public. There 
may be mistakes and limitations in the underlying gummed-paper 
data, but they are probably honest mistakes and limitations.
    2. Nevertheless, there are a number of reasons to expect 
that the current best estimates for exposure may be low.
    Generating historical exposure estimates requires making 
judgments, particularly in choosing values for parameters that 
enter the exposure model. It is difficult, even without the 
political pressure that radiological dose estimates have 
engendered, to pick an unbiased set of best-estimate parameter 
values. Thus, the choice of study members and the makeup of 
advisory committees can play a crucial role in a study's 
outcome, and hence can generate ferocious infighting. Usually, 
there are many free model parameters to specify in a dose 
reconstruction exercise. A member of the analytical team with a 
strong particular bias, or a member of an advisory committee 
who believes he or she knows the ``correct'' answer, not to 
mention the employers of the team, can selectively, even 
unconsciously, bias some of the results for non-scientific 
reasons. Without countervailing critiques of the choices made 
for important parameters, analysts may adjust parameters to 
satisfy advisory committees, supervisors, or dominant team 
members. Only if the advisory committees have a full 
representation of independent scientists with varying points of 
view can the choice of parameter values be kept from favoring 
the perceived goals of one political faction or agency. I have 
found some hints of this phenomenon in the early descriptions 
of the work provide by NCI. [6] Congressional investigators 
should scrutinize the makeup of the various advisory committees 
over time, the process by which study leaders and members were 
chosen, and whether or not independent scientists were 
appointed as members. Investigators should also examine if NCI 
was prepared to handle the heavy politicization that has 
existed in this country over radiation health effects. I have a 
very high degree of respect for NCI, based on personal 
experience and knowledge of its work. NCI has done many 
marvelous studies. It has a top notch, peer-review process for 
scientific projects, but it may not have been prepared for the 
hard-ball politics that was played with radiation health 
effects by other government agencies and influential figures. 
It would be a tragedy if public confidence in NCI were 
undermined because of this incident. Full and open disclosure 
at this point is the best way to protect the reputation of NCI. 
[7]
    3. The uncertainties in the dose estimates may have been 
understated in the counties with lower exposure.
    Published articles dealing with the underlying databases 
have pointed out certain inconsistencies in estimates made 
outside the highest dose regions. [8] The inconsistencies imply 
that the uncertainties in the lower dose regions are likely to 
be greater than stated in the NCI report. Thus, it may be 
unwise to dismiss consideration of medical actions in these 
areas, based solely on the dose ranges provided in the NCI 
report.
    4. The NCI reports published to date have ignored diseases 
other than thyroid cancer.
    Thyroid nodules, another known consequence of radiation 
exposure, have been neglected by NCI, even though such nodules 
require follow-up, and sometimes surgery. The authors of the 
thyroid disease study carried out around the Nevada Test Site 
were much more than ``suggestive'' when it came to induced 
neoplasms:
    ``We conclude that in the cohort that was studied, an 
excess of between one and 12 neoplasms (0 to six malignancies) 
was probably caused by exposure to fallout radioiodines from 
nuclear weapons testing.'' [9]
    The NCI report is strangely silent on this consequence of 
radioiodine exposure.
    Of great concern is that physicians should be alerted to 
watch for signs and symptoms of lesser diseases than thyroid 
cancer, namely autoimmune hypothyroidism, mild thyroiditis, and 
possibly hyperthyroidism incident to Graves' disease. These 
diseases can be initiated by low to moderate radiation doses, 
the recent literature suggests, presenting themselves years 
after exposure. They are most likely caused by an autoimmune 
reaction in susceptible individuals. Once triggered, the body 
attacks its own thyroid cells, eventually causing clinical 
disease. Such effects were not identified in the A-bomb 
survivors by Nagataki et al. until 40 years after the bombing 
of Japan. [10] This finding suggests that these diseases should 
now be evident in the US population exposed to fallout doses of 
about 40 rads, assuming that the A-bomb situation is 
comparable. [11]
    The extensive data collected on people living around the 
1986 Chernobyl disaster show that radioiodine exposure at 
surprisingly low doses--between zero and 30 rads, mid-point 
equals 15 rads--leads to significant production of antithyroid 
antibodies. [12] The dose response stays fairly flat as dose 
increases up to a few hundred rads suggesting that a 
susceptible subgroup exists that is sensitive to low doses. 
Now, the presence of antibodies alone does not necessarily 
imply any diseases are yet present in this population, neither 
autoimmune thyroiditis, nor autoimmune hypothyroidism, nor 
autoimmune hyperthyroidism. However, the presence of elevated 
thyroid antibodies is a well-known risk factor for chronic 
thyroiditis and hypothyroidism. [13], [14]
    Most of these data on autoimmune thyroid disease are new 
[15] and contradict some older published work. [16], [17], [18] 
The major study of the Nagasaki population wasn't published 
until 1994 [19] and the striking thyroid antibody study on the 
Chernobyl population wasn't published until 1996. [20] Although 
not yet appreciated or accepted by all scientists, the new 
information contained in these studies needs to be communicated 
to physicians and other health providers practicing in those 
counties where exposures may have exceeded an appropriate 
threshold, taken here to be 15 rads. Since exposure 
uncertainties may be as high as a factor of ten, these diseases 
could be appearing today in counties with average exposures as 
low as 1.5 rads. [21]
    5. I question if NCI has the full range of expertise 
necessary to consider these non-cancerous, autoimmune diseases 
in its contract with the Institute of Medicine.
    An important question is whether or not the contract NCI 
has developed with the Institute of Medicine will allow the 
Institute to consider this new literature in detail, as well as 
its importance for medical surveillance. Possibly, other 
divisions of NIH with expertise in autoimmune diseases, 
including immunology and endocrinology, should have a role in 
the follow-up study NCI has commissioned.
    6. A medical response program is in order for a significant 
fraction of the United States population exposed to fallout.
    Such a program should deliver medical information to 
physicians, perhaps through medical societies or continuing 
education. It should inform exposed persons of the early or 
pre-clinical symptoms of disease. It should provide medical 
surveillance in areas where the prior likelihood of disease is 
likely to be significant. Finally, in such areas, it should 
provide treatment for persons with a wide range of thyroid 
diseases who do not have adequate medical care due to insurance 
limitations.
    Obviously, a great deal of thought needs to be given to 
designing a proper medical surveillance program. However, based 
on the review of the literature and on discussions with Dr. 
Mayer, it seems clear that a carefully designed program would 
provide tremendous health benefits for those who do not already 
have, or do normally take advantage of, regular and thorough 
medical care. [22], [23] The monitoring efforts required will 
generally not entail a large individual expense, although the 
total for the country will be significant. A surveillance 
program might consist solely of regular thyroid palpations and 
blood tests for thyroid dysfunction, including a ``TSH'' assay.
    Diseases that should be monitored:
    A. Thyroid cancer and its typical precursor, thyroid 
nodularity.
    As has been discussed by NCI, cancer risks are heavily 
weighted towards those exposed as children, particularly those 
exposed at the ages of 0-4 years. For external radiation, 
cancer has been confirmed in the literature down to an average 
dose of 9 rads, [24] and there is no evidence of a threshold to 
suggest cancer cannot be caused down to lower doses. Even if 
iodine-131 exposure were to be somewhat less of a risk factor 
for cancer compared to external radiation, this reduced risk 
would not change the fact that disease will result from the 
weapons fallout. It would only change the expected number of 
cases.
    B. Autoimmune thyroid diseases should also be monitored, 
particularly autoimmune hypothyroidism, autoimmune thyroiditis, 
as well as hyperthyroidism incident to Graves' disease. [25]
    The lowest dose in the literature shown to trigger the 
autoimmune thyroid process is found in a study of Chernobyl-
exposed children. It is 15 rads. [26] An important goal of a 
medical surveillance program for autoimmune thyroid diseases, 
in addition to identifying any severe cases that have been 
missed, should be to identify mild and subclinical cases of 
hypothyroidism, which are difficult to detect and easily 
confused with non-disease conditions. Studies show that people 
with subclinical hypothyroidism benefit from drug treatment, 
leading to improved quality of life. [27] Paradoxically, severe 
cases are easily identified and easily treated with corrective 
medicines. Mild cases can go on for long periods of time, 
reducing the quality of life for people until symptoms get so 
severe that the need for treatment is recognized.
    Although it is now clear that those children who drank milk 
at the time of exposure are the key population to monitor for 
thyroid nodularity and cancer, the effects of exposure age on 
the risk of autoimmune disease is not known. This uncertainty 
complicates the picture for determining the scope of a medical 
surveillance program for radiation-induced autoimmune diseases.
    7. Information on the importance of the food chain for 
radiation exposures has been known for a long time. Government 
health physicists have known of the importance of the food 
pathway as a source of exposure since 1946. [28] They knew 
about the value of early intervention by, at least, 1958. [29] 
By the time of many, if not all, of the weapons tests, 
government officials knew or should have known that a 
mitigation strategy would prevent injury. Advisories to the 
public to avoid drinking fresh milk after weapons tests, 
particularly after rain, could have significantly reduced the 
expected number of thyroid cancer and nodules (and, as we now 
know, non-functioning thyroids). Such advisories could have 
been presented simply as a precaution, without having to admit 
to the public that any harm would necessarily fall upon them. 
Obviously, such a warning might have weakened public support 
for nuclear weapons testing and, therefore, would have had to 
be balanced against issues of national security. Somewhere, 
there may exist records of high level discussions about this 
difficult choice. Their content may be very revealing in 
helping to determine the degree of responsibility owed by the 
government to the public for the high exposures.
    8. It was not necessary to know the full outcome of the NCI 
study before making recommendations on medical surveillance. By 
1982, when Congress asked NCI to undertake the fallout study, 
the connection between thyroid cancer and radioiodine was well 
known. At what point should NCI or DOE have taken steps to 
inform the medical community about the potential risks to their 
patients? Answering this question will, no doubt, be a key goal 
of congressional investigations.
    9. There may be other relevant studies languishing under 
bureaucratic confinement
    The fact that NCI has taken so long to report the essential 
public health message in this work raises questions about other 
studies that may be ongoing. [30] For instance, are political 
pressures slowing reports of the NCI's Chernobyl study? Will 
the Institute of Medicine have access to the preliminary 
results? Are there pending studies in other government 
agencies, such as DOE, that bear on the questions before the 
committee?

                               CONCLUSION

    There are a number of factors that suggest a medical 
information, surveillance, and treatment program is in order 
for those exposed to weapons test fallout. These factors are 
(1) the magnitude of the projected radioiodine exposures, (2) 
the large uncertainties in the estimates, and (3), the recent 
findings that autoimmune thyroid diseases can be triggered at 
relatively low doses of radiation.
    I hope that the need for action not be forgotten as 
attention focuses on why there has been such a delay by 
government agencies in formulating a recommendation on medical 
surveillance.

                            ACKNOWLEDGEMENTS

    I thank Dr. Mayer for advising me on the medical aspects of 
my statement and Joseph Wayman and David Beavers for collecting 
some of the historical documents relating to the discovery of 
the food exposure pathway for radioiodine

                               References

    [1] Correspondence relating to this testimony should be 
sent to Dr. Beyea at [email protected]. Dr. Beyea is Senior 
Scientist at Consulting in the Public Interest, Lambertville, 
NJ. Web page: www.cipi.com. He has performed dose 
reconstructions used in epidemiology studies at TMI, e.g., 
``Cancer Rates after the Three Mile Island Nuclear Accident and 
Proximity of Residence to the Plant'', (Hatch, Wallenstein, 
Beyea, Nieves, Susser), American Journal of Public Health, 
18(6), June 1991; ``Cancer Near the Three Mile Island Nuclear 
Plant: Radiation Emissions'', (Hatch, Beyea, Nieves, Susser), 
American Journal of Epidemiology, Sept. 1990.
    [2] Dr. Mayer is a biostatistician and clinical 
investigator currently on the faculty of Johns Hopkins Schools 
of Public Health and Medicine, Baltimore, Maryland; Good 
Samaritan Medical Center, Phoenix, Arizona; and Arizona State 
University.
    [3] National Cancer Institute, Press Kit, August 1, 1997.
    [4] Thompson, CB and MacArthur, RD, ``Challenges in 
Developing Estimates of Exposure Rate Near the Nevada Test 
Site, Health Physics, 71: 470-476, 1996. See also: Kirchner et 
al., ``Estimating Internal Dose Due to Ingestion of 
Radionuclides from Nevada Test Site Fallout, Health Physics, 
71: 487-495, 1996; Till et al., ``The Utah Thyroid Cohort 
Study: Analysis of the Dosimetry Results,'' Health Physics, 68: 
472-483, 1995; Simon, SJ et al., ``The Utah Leukemia Case-
Control Study: Dosimetry Methodology and Results,'' Health 
Physics, 68: 460-471, 1995.
    [5] I have reviewed internal EML documents in connection 
with a pending class action suit at the Rocky Flats plutonium 
finishing facility.
    [6] Analysts had to pick a best estimate for the ``intake-
to-milk'' transfer coefficient. The NCI report states, 
``Reported literature values range from 2 x 10-\3\ 
to 4 x 10-\2\ d L-\1\ but it seemed that 
fallout studies yielded values in the lower part of the range. 
For the purposes of this report, it is assumed that the median 
value of fm for \131\I and for cows is 4 x 10-\3\ d 
L-\1\.'' In my experience, such vague language is 
sometimes a signal that decisions have been made for non-
scientific reasons. Although this may not be the case here, the 
vagueness of the reasons given for using a lower than average 
value provides justification for scrutinizing the decision 
process that was used to choose parameter values.
    [7] I am concerned, therefore, about the equivocal language 
that still remains in the NCI's press material of August 1, 
1997, particularly in the July 1997, ``Background Information 
on Thyroid Cancer and Radiation Risk,'' which was included in 
the new packet. It reads like a press release from the old 
Atomic Energy Commission.
    [8] Thompson et al., op. cit., p 473.
    [9] Kerber, RA, Till, JE, Simon, SL, Lyon, JL, et al., ``A 
Cohort Study of Thyroid Disease in Relation to Fallout from 
Nuclear Weapons Testing.'' JAMA, 270: 2076-2082. 1993.
    [10] In a dose range from 0- to 100-rads. The response 
curve was non-linear. Nagataki, S. et al., ``Thyroid diseases 
among atomic bomb survivors in Nagasaki.'' JAMA 272 : 364-371 
(1994).
    [11] Although some scientists maintain that Iodine-131 is 
less effective than the external radiation delivered at 
Hiroshima and Nagasaki, few scientists would maintain that 
there is no effect. Furthermore, Chernobyl data on children 
show the precursors of these diseases, namely antithyroid 
antibodies in persons exposed to Iodine-131 (World Health 
Organization, op. cit.).
    [12] Levels of antithyroid antibodies have been measured in 
thousands of children at Chernobyl, demonstrating that these 
precursors of autoimmune disease have increased dramatically in 
those exposed to 0 to 30 rads. I take the mid-point of this 
region, namely 15 rads, as the practical threshold for a 
medical surveillance program aimed at autoimmune thyroid 
disease. (Souchkevitch, G.N. et al. eds. Health Consequences of 
the Chernobyl Accident: Results of the IPHECA Pilot Projects 
and Related National Programmes, Geneva: World Health 
Organization, pp. 264-68 (1996).)
    [13] I emphasize that the findings of antithyroid 
antibodies do not prove disease is yet present, only that the 
autoimmune process has started in the Chernobyl population. 
Progression to autoimmune thyroiditis and hypothyroidism, 
however, is expected based on epidemiological surveys of the 
background incidence of thyroid disease in the general public. 
(Vanderpump, M.P.J. and Tunbridge, W.M.G. ``The Epidemiology of 
Thyroid Diseases'' (1996), in Werner and Ingbar's The Thyroid, 
7th ed., eds. Braverman, L.E. and Utiger, R.D., Philadelphia: 
Lippincott-Raven, pp. 474-482 (1996). Also, Vanderpump, M.P.J. 
et al. ``The incidence of thyroid disorders in the community: a 
20-year follow-up of the Whickham Survey.'' Clinical 
Endocrinology 43: 55-68 (1995). Relevant information can also 
be found in Weetman, A.P. ``Chronic autoimmune thyroiditis,'' 
in Werner and Ingbar's The Thyroid, op. cit., pp. 738-48 Also, 
Geul, K.W. et al. ``The importance of thyroid microsomal 
antibodies in the development of elevated serum TSH in middle-
aged women: associations with serum lipids.'' Clinical 
Endocrinology 39 (3): 275-80 (1993). Also, Bilous, R.W. and 
Tunbridge, W.M.G. ``The epidemiology of hypothyroidism--an 
update.'' Bailliere's Clinical Endocrinology and Metabolism 2: 
531-540 (1988).
    [14] The existence of these antibodies is often considered 
to be sufficient evidence of subclinical autoimmune thyroiditis 
(Weetman, A.P. ``Chronic autoimmune thyroiditis,'' in Werner 
and Ingbar's The Thyroid, 7th edition, eds. L.E. Braverman and 
R.D. Utiger, Philadelphia: Lippincott-Raven, pp. 738-48 
[1996]), because, for one reason, local thyroiditis is 
correlated with such antibodies at autopsy (Vanderpump, M.P. et 
al. ``The incidence of thyroid disorders in the community: a 
twenty-year follow-up of the Whickham Survey,'' Clinical 
Endocrinology 43: 55-68 [1995]).
    [15] Although the early work by Malone and Cullen is 
consistent with the Chernobyl antibody plateau. (The Lancet, 
July 10, 1976, pp 73-75.)
    [16] Morimoto et al., J Nucl Med 28:1115-1122, 1987 used an 
earlier version of the A-bomb dosimetry, the so-called T65-
dosimetry, that is now thought to be inferior to later 
dosimetry efforts (e.g., DS86). Morimoto is a 30-year follow-up 
study compared to 40 years in the Nagataki study. Furthermore, 
the Morimoto group only looked at two data points, the 0 rads 
group and the 100+ rads group. In other words, Morimoto skipped 
the dose region where Nagataki et al. found their greatest 
excess. This choice reduces the number of cases compared to 
Nagataki. For all these reasons, it is not surprising that 
Morimoto did not find a detectable effect.
    [17] Yoshimoto et al., ``Prevalence Rate of Thyroid 
Diseases among Autopsy Cases of the Atomic Bomb Survivors in 
Hiroshima, 1951-85, Radiation Research, 141: 278-286 (1995), is 
an autopsy study of A-bomb survivors that looked at the 
condition, ``chronic thyroiditis.'' This condition is similar 
to the positive-antibody, subclinical condition studied by 
Nagataki et al. Yoshimoto et al., assumed a linear response 
curve, which would have made the response less statistically 
significant. Although Yoshimoto et al. published their results 
in 1995, they analyzed autopsies between 1951 and 1985. This 
means that the average time since exposure was much less than 
for Nagataki et al., who looked at live people in 1985-87. The 
paper by Nagataki et al., clearly has a much longer study 
period.
    [18] As for the study of Utah fallout by Kerber et al., op. 
cit., the lack of finding of an effect of low dose radiation on 
the risk of hypothyroidism in Utah is not that surprising. The 
doses covered by Kerber's study are quite low, and Maxon and 
Saenger argue that the data may indicate a threshold around 10-
20 rads. (Werner and Ingbar's The Thyroid, op. cit. pages 342-
351.) Moreover, the results are neither inconsistent with 
Nagataki nor the Chernobyl antibody data. Furthermore, the 
Kerber study took blood samples on a narrower population than 
did Nagataki. Kerber only took blood samples from those people 
in the study group who first showed clinical evidence of 
thyroid problems, a potential statistical bias, whereas 
Nagataki took blood samples from the entire cohort. 
Interestingly, a companion study of fetal exposures around the 
Nevada Test Site by Lloyd, Tripp and Kerber, Health Physics, 
70: 559-662, 1996, shows, according to my analysis, a similar 
dose response curve for thyroiditis and hypothyroidism as found 
in Nagataki.
    [19] Nagataki, S. et al., op. cit. Kaplan et al. were the 
first group to find indications that autoimmune thyroid doses 
could be caused by moderate doses (around 60 rads): Kaplan M.M. 
et al. `` Thyroid, parathyroid, and salivary gland evaluations 
in patients exposed to multiple fluoroscopic examinations 
during tuberculosis therapy: a pilot study.'' Journal of 
Clinical Endocrinological Metabolism 66: 376-382. (1988)
    [20] Souchkevitch, G.N. et al. eds. Health Consequences of 
the Chernobyl Accident: Results of the IPHECA Pilot Projects 
and Related National Programmes, Geneva: World Health 
Organization, pp. 264-68 (1996). See Also: Vykhovanets, E.V. 
``Association between increased doses of Iodine-131 to the 
thyroid gland and autoimmune disorders in children living 
around Chernobyl,'' Poster presented at the February 1997 
annual meeting of the American Association for the Advancement 
of Science.
    [21] I do not mention here individual variability, which 
increases the ranges of dose that need to be considered.
    [22] See Danese, M.D. et al. ``Screening for mild thyroid 
failure at the periodic health examination--a decision and 
cost-effectiveness analysis.'' JAMA 276: 285-292 (1996).
    [23] I do not consider here the question of whether private 
health care companies should be reimbursed for treatments that 
they provide for thyroid conditions in the highly exposed 
counties, nor whether affected citizens should receive 
compensation.
    [24] Ron E, Modan B, Preston D, Alfandary E, Stovall M, 
Boice JD Jr. ``Thyroid Neoplasia Following Low-Dose Radiation 
in Childhood.'' Radiat Res 120: 516-531, 1989; Ron E, Griffel 
B, Liban E, Modan B. ``Histopathologic Reproducibility of 
Thyroid Disease in an Epidemiologic Study.'' Cancer 57: 1056-
1059, 1986.
    [25] Effects have been seen at doses of 30 to 200 rads. 
(Katayama, S.; Shimaoka, K.; Piver, M.S.; Osman, G.; Tsukada, 
Y.; and Suh, O. (1985) ``Radiation associated hypothyroidism in 
patients with gynecological malignancies.'' J. Med. 16: 587-
596.). Although there is less evidence in the literature for 
the association with hyperthyroidism at low doses of radiation, 
it seems plausible that autoimmune hyperthyroidism should 
eventually result, once the autoimmune process has started, and 
should also be monitored.
    [26] World Health Organization, op. cit.
    [27] Arem, R. and Escalante, D. ``Subclinical 
hypothyroidism: epidemiology, diagnosis and significance.'' Adv 
Intern Med 41: 213-250 (1996).
    [28] As part of the production of the first atomic bombs, 
large amounts of radioiodine were released into the atmosphere 
at the Hanford weapons facility in Washington. Accumulation of 
radioiodine in sheep was discovered around Hanford as early as 
1946. (Healy, JW, ``Accumulation in the thyroid of sheep 
grazing near HEW,'' Hanford report, HW3-3455, March 1946. See 
also: Parker, H.M. 1946. Tolerable Concentration of Radio-
iodine on Edible Plants. Hanford Atomic Products Operation, 
G.E., Richland, Washington. NTIS, HW-7-3217.) Beginning in 
1950, scientists at the Experimental Animal Farm at Hanford fed 
radioiodine to sheep and studied thyroid damage. This 
information was all classified. By 1955, the food pathway had 
been discovered, ``The principal hazard of iodine release to 
the environs arises from deposition in vegetation and 
subsequent ingestion by animals and humans'' (OM Hill, 
``Symposium on Iodine Problem,'' Hanford report, HW-039073). 
Limits were set on consumption of contaminated milk. These 
findings were publicly stated at least by 1955: ``Two 
significant routes of entry are consumption of fresh garden 
produce, and drinking milk from cows on contaminated pasture.'' 
(Parker, H.M. 1955. Radiation Exposure from Environmental 
Hazards. Hanford Atomic Products Operation, G.E., Richland, 
Washington. NTIS, Prepared for International Conference on the 
Peaceful Uses of Atomic Energy. p. 6.).
    [29] By 1958, it was even known that intake of normal 
iodine could block the uptake of radioactive iodine in sheep 
(Bustad et al., American Journal of Veterinary Research, Vol 
19, p. 250., October 1958).
    [30] This is not the only time in recent years that efforts 
have apparently been made to delay publication of politically 
sensitive studies involving fallout hazards. As part of an 
agreement over discovery in the Hanford litigation, I was 
allowed to read a controversial draft manuscript by Musolino et 
al. that recalculated exposure to the Marshallese following 
early weapons tests in the Pacific. At the time, DOE's 
Brookhaven Laboratory was withholding publication of this 
report, and, to this date, we have still not been apprised of 
its release. Only vigorous oversight by Congress can override 
the bureaucratic temptation to delay unpleasant information as 
long as possible, even though valuable time may be lost in 
providing early detection of medical conditions.

                         INSTITUTE OF MEDICINE

    Senator Specter. Dr. Beyea, would you specify in writing 
for the subcommittee exactly what you think ought to be done 
with respect to the particularities you just mentioned?
    Dr. Beyea. To a certain extent I have done that in my 
written statement. I would be glad to do that. I have a lot of 
confidence in the Institute of Medicine if they have a contract 
which is written properly that will allow them to look at all 
these issues and if they bring in the right people.
    So if we can do that and make sure there is a broad 
representation on the Institute of Medicine's panel, I am 
confident the Institute will bring this to the forefront.
STATEMENT OF TIMOTHY CONNOR, ASSOCIATE DIRECTOR, ENERGY 
            RESEARCH FOUNDATION
    Senator Specter. We now turn to Mr. Timothy Connor, 
associate director of the Energy Research Foundation in 
Spokane, WA. Mr. Connor has published several articles on low 
dose radiation and public health. Thank you for joining us, Mr. 
Connor. The floor is yours.
    Mr. Connor. Thank you, Senator Specter. Thank you, Senator 
Harkin, for the invitation this morning. I will try to keep my 
remarks to 3 minutes.
    I come here this morning with the hope that today's hearing 
brings us near----
    Senator Specter. If you spill over a little, it is OK.
    Mr. Connor [continuing]. Brings us nearer to closing the 
circle of accountability and reconciliation around one of the 
more difficult problems in our country's history. My mother's 
family is from Pasco, WA, just a few miles downstream from the 
Hanford Nuclear Reservation along the Columbia River.
    And as it turns out, I was actually born at an Army 
hospital at Hanford in 1956 while my dad was on active duty in 
Korea.
    It was not until the 1980's that the term ``Hanford 
downwinder'' came into wide usage in eastern Washington. This 
is because it was the spring of 1986 before citizen activists 
and journalists finally succeeded in forcing the Federal 
managers of the Hanford site to make public the historical 
documents proving what many people in our part of the world 
already suspected: In their haste to manufacture the plutonium 
used in America's first nuclear weapons, the operators of 
Hanford's plutonium processing plants had released hundreds of 
thousands of curies of iodine-131 into the atmosphere.
    The Hanford revelations had a profound effect on public 
debate and public sentiment in eastern Washington and 
throughout the Northwest. While scientists continue working to 
better answer the question of how widely people were exposed 
and how many cancers and other illnesses can be attributed to 
the emissions, there is overwhelming sentiment that what 
happened was wrong. Civilized governments are not supposed to 
expose their citizens to radiation or other hazards without 
bothering to warn them or, worse, go for decades without 
alerting them to the continuing health risks of the exposures.
    This conclusion is shared by people who have vastly 
different views about nuclear weapons. Eastern Washington is a 
rather conservative place and many people are understandably 
proud of Hanford's historic role in forcing an end to the war 
with Japan. Still, patriotism does not allow us to excuse what 
happened to people living downwind of Hanford during the 
forties and fifties.
    Perhaps the hardest thing for people to accept was the 
knowledge that the Federal Government hired and was paying 
people at Hanford to study exposures and the biological and 
health effects of radiation and yet for three decades the truth 
about the Hanford releases was withheld. For three decades 
people were regularly assured their health was being protected. 
Even on the day that Federal officials released the documents 
disclosing the radiation releases, one of them stood behind a 
podium with a Federal seal on it and said: ``There is no reason 
to expect observable harm.''
    Regardless of how people in the Columbia basin felt about 
plutonium, the bomb, the war, and the hundreds of millions of 
dollars a year coming to Hanford, there is little question now 
about how they feel about being lied to, even if the lies were 
cleverly composed lies.
    What happened at Hanford is relevant to today's hearing for 
two reasons. The first is that the circumstances surrounding 
the National Cancer Institute's handling of the radioactive 
iodine fallout study are remarkably similar to those 
surrounding the Hanford emissions. While it is true that NCI 
did not create the fallout, it was charged with the important 
task of telling Congress and the American people about what 
happened.
    The Institute failed in this responsibility. It failed 
because its researchers some time ago had compiled and analyzed 
enough evidence to realize that this was more than just a 
science project. They knew or should have known that at least 
thousands of infants and children throughout America had 
received thyroid doses putting them at substantially greater 
risk for thyroid cancer and other thyroid diseases. People had 
a right to know and had they known that knowledge may well have 
made a difference in their lives.
    The hardest thing to accept is that once again Federal 
scientists and officials chose to withhold information vital to 
the health and wellbeing of citizens whose interests they are 
supposed to be serving. Once again, people are outraged with 
the knowledge that their illnesses might have been prevented or 
their suffering diminished if only they had been told they were 
at greater risk due to their exposures.
    Once again, people feel like nuclear age guinea pigs or 
mere statistics, as though the Government has infinitely more 
interest in studying them than in helping them.
    The second reason the Hanford experience is relevant to 
this study is that we were supposed to have learned from 
Hanford, and not only from Hanford, but from all the other 
disturbing revelations of the 1980's and before about the way 
Federal science has been compromised in the field of radiation 
and health. We have known for many years that it was a mistake 
to allow the Department of Energy and its predecessors to 
dominate the avenues and processes by which the Government is 
supposed to be protecting public health and the environment 
from the effects of the Nation's nuclear weapons production and 
testing activities.
    Part of this domination involved the control of DOE and its 
predecessors exercise over health and health-related research 
activities involving radiation exposures to workers and the 
public.
    I want to conclude by mentioning that former Energy 
Secretary James Watkins in 1990 acted on these criticisms by 
signing a memorandum of understanding [MOU] with the Department 
of Health and Human Services which transferred analytic 
epidemiologic studies through this memorandum to HHS. Those 
studies have been located in the Centers for Disease Control, 
where the Center for Environmental Health looks at populations 
and the National Institute of Occupational Safety and Health 
looks at worker studies.
    It is interesting that NCI was left out of these reforms, 
and these reforms were intended to allow the kind of sunshine, 
the public oversight and communication that was not present in 
the study. This is a part of history we need to look at and 
make sure that, even though it is important, as the two doctors 
said, to look at the health consequences of this, it is also 
important to keep our eye on the necessary reforms. We cannot 
go through another round, yet another round, in our history 
where the American people feel that the Government is holding 
out on them and not sharing with them, not sharing the 
responsibility for their experiences due to releases that the 
Government is responsible for.
    So I would highly second Dr. Lyon's comments. We have a 
structure now that would allow us to provide this oversight and 
openness. It is important that we use it. In fact, I think it 
is time that we look at legislation to replace the so that 
these studies are reconstituted at HHS, so that this kind of 
study never happens again.

                           PREPARED STATEMENT

    One of the truly unfortunate things about this study is 
that it was headed by a former Department of Energy official 
who managed it in much the way the Department of Energy managed 
so many studies that were discredited. We cannot allow that to 
happen again, and if there is one thing that we do on the 
reform side, let us look at that and make sure this does not 
happen again.
    Thank you.
    [The statement follows:]

                    Prepared Statement of Tim Connor

    I come here this morning with the hope that today's hearing 
brings us nearer to closing the circle of accountability and 
reconciliation around one of the more difficult problems in our 
nation's history. The problem, in a nutshell, is our profoundly 
uneasy experience as a democracy facing the social, 
technological, and moral challenges of building, testing, and 
otherwise owning a large arsenal of nuclear weapons.
    My mother's family is from Pasco, Washington just a few 
miles downstream from the Hanford Nuclear Reservation along the 
Columbia River. As it turns out, I was born at an army hospital 
at Hanford in 1956 while my father was on active duty in Korea. 
I live in Spokane, now, which is approximately a hundred miles 
northeast of Hanford.
    It was not until the 1980's that the term ``Hanford 
downwinder'' came into wide usage in Eastern Washington. This 
is because it was the spring of 1986 before citizen activists 
and journalists finally succeeded in forcing the federal 
managers of the Hanford site to make public the historical 
documents proving what many people in our part of the world 
already suspected. In their haste to manufacture the plutonium 
used in America's first nuclear weapons, the operators of 
Hanford's plutonium processing plants had released hundreds of 
thousands of curies of radioactive iodine-131 to the 
atmosphere.
    The Hanford revelations had a profound effect on public 
debate and public sentiment in Eastern Washington and 
throughout the Pacific Northwest. While scientists continue 
working to try to better answer the question of how widely 
people were exposed and how many cancers and other illnesses 
can be attributed to the Hanford emissions, there is 
overwhelming sentiment that what happened was wrong. Civilized 
governments are not supposed to expose their citizens to 
radiation or other hazards without bothering to warn them or, 
worse, go for decades without alerting them to the continuing 
health risks of the exposures.
    This conclusion is shared by people who have vastly 
different views about whether we need large numbers of nuclear 
weapons to defend ourselves. Eastern Washington is a rather 
conservative place and many people are understandably proud of 
Hanford's historic role in forcing an end to the war with 
Japan. Still, patriotism does not allow us to excuse what 
happened to people living downwind of Hanford during the 1940's 
and 1950's.
    Perhaps the hardest thing for people to accept was the 
knowledge that the federal government hired and was paying 
people at Hanford to study exposures and the biological and 
health effects of radiation. And, yet, for three decades the 
truth about the Hanford releases was withheld. For three 
decades people were regularly assured their health was being 
protected. Even on the day that federal officials released the 
Hanford historical documents disclosing the large radiation 
releases, one of them stood behind a podium with a federal seal 
affixed to it. He said, and I quote, ``There is no reason to 
expect observable harm.''
    Regardless of how people in Pasco, Ritzville, Dayton, 
Pendleton, Spokane, and in the fields above Eltopia felt about 
plutonium, the bomb, the war, and the hundreds of millions a 
year in federal dollars coming to Hanford, there is little 
question now about how they feel about being lied to, even if 
the lies were cleverly composed.
    What happened at Hanford is relevant to today's hearing for 
two reasons.
    The first is that the circumstances surrounding the 
National Cancer Institute's handling of the radioactive iodine 
fallout study are remarkably similar to those surrounding the 
Hanford emissions. While it's true that NCI didn't create the 
fallout, it was charged with the important task of telling 
Congress and the American people about what happened. It failed 
in this responsibility. It failed because its researchers, some 
time ago, had compiled and analyzed enough evidence to realize 
that this was more than just a science project. They knew, or 
should have known, that at least thousands of infants and 
children throughout America had received thyroid doses putting 
them at substantially greater risk for thyroid cancer and other 
thyroid diseases. People had a right to know. And had they 
known, that knowledge may well have made a difference in their 
lives.
    The hardest thing to accept is that once again, federal 
scientists and officials chose to withhold information vital to 
the health and well-being of citizens whose interests they are 
supposed to be serving. Once again people are outraged with the 
knowledge that their illnesses might have been prevented, or 
their suffering diminished, if only they'd been told they were 
at greater risk due to their exposures. Once again people feel 
like nuclear age guinea pigs or mere statistics--as though the 
government has infinitely more interest in studying them than 
in helping them.
    The second reason the Hanford experience is relevant to 
this study is that we were supposed to have learned from 
Hanford. And not only from Hanford but from all the other 
disturbing revelations of the 1980's, and before, about the way 
federal science has been compromised in the field of radiation 
and health. We've known for many years that it was a mistake to 
allow the Department of Energy and its predecessors to dominate 
the avenues and processes by which the government is supposed 
to be protecting public health and the environment from the 
effects of the nation's nuclear weapons production and testing 
activities. Part of this domination involved the control DOE 
and its predecessors exercised over health and health-related 
research activities involving radiation exposures to workers 
and the public.
    In 1990 the Department of Energy finally bent to 
Congressional and public pressure when Energy Secretary James 
Watkins signed a Memorandum of Understanding with Health & 
Human Services Secretary Louis Sullivan. This agreement, 
renewed last year, transferred funding and managerial control 
over occupational and public health studies involving radiation 
exposures to the Centers for Disease Control & Prevention and 
the National Institute for Occupational Safety and Health.
    Just as importantly, the 1990 MOU initiated a process to 
enact long overdue reforms in the way health and health-related 
studies involving public exposures were to be conducted. 
Specifically, there were to be no more closed doors behind 
which scientists worked without public oversight to decide how 
to study communities and what, if anything, to tell citizens 
about their exposures and health risks.
    One glaring weakness in these reforms--a weakness vividly 
exposed by NCI's mishandling of the I-131 fallout study--is 
that there is still federally-funded radiation research, much 
of it being done at the National Cancer Institute, which 
proceeds outside of the reforms enabled by the 1990 MOU. What 
is especially ironic in this instance is that the NCI fallout 
study was requested by Congress for the purpose of furthering 
the national accounting of health risks to the American people 
caused by U.S. nuclear weapons test fallout. And yet, it was 
managed by a former Department of Energy official in the same 
closed manner--without public oversight and meaningful external 
review--that brought such discredit to the DOE radiation 
research program.
    Surely, much work is needed to determine how the nation can 
and should respond to those who were put at substantially 
greater health risk due to the exposures that the NCI study 
appears to document. But I'd like to encourage the Subcommittee 
to pursue and insist upon the steps that are needed to ensure 
that the important science that remains to be done in this area 
is done openly, with public oversight and robust independent 
peer review. The American people need to know, once and for 
all, that federal scientific research addressing the health 
risks and consequences of radiation and other hazardous 
substances is really being done on their behalf and not on 
behalf of the institutional or political interests of 
government agencies and bureaucracies. While it is very late in 
the day to institute these reforms, it is absolutely necessary 
to see them through. It is an important part of making peace 
with our past and, more importantly, with ourselves.
    One of the more disturbing aspects of the way the NCI I-131 
fallout study was conducted is that there was ample opportunity 
for NCI administrators to know better. It is hard to imagine 
how NCI officials could have missed the public controversy in 
the late 1980's with regard to the conduct of radiation health 
research funded through DOE. In August of 1989 Secretary of 
Energy James Watkins announced to the Senate Governmental 
Affairs Committee that he would empanel some of the nation's 
top health experts to review the issues and status surrounding 
DOE's radiation health research program and report back to him 
with recommendations. At the time, there was legislation 
drafted by members of both the Senate and the House that would 
have formally transferred the radiation health research program 
to the Department of Health and Human Services.
    The body Secretary Watkins appointed--the Secretarial Panel 
for the Evaluation of Epidemiologic Research Activities 
(SPEERA)--was chaired by Kristine Gebbie, then Washington 
state's Secretary of Health. SPEERA reported its findings to 
Secretary Watkins in March of 1990 and recommended several 
major reforms. A number of the principles and recommendations 
advocated by SPEERA are worth revisiting in the aftermath of 
NCI's mishandling of the I-131 fallout study. Among the 
principles SPEERA articulated were the following: [1]
    ``The credibility of scientific research is essential and 
is directly dependent upon openness. The benefit--credibility--
derived from maximum public access to health information 
greatly exceeds the risks of misuse or misunderstanding.''
    ``The findings of any epidemiologic research must be 
reported fully and promptly to all who are affected.''
    ``The public has a right to know about collective health 
experiences and risks to which they were exposed.''
    ``Epidemiologic findings must be reported fully and 
promptly to policy makers so that findings are integrated into 
policy decisions.''
    While the NCI I-131 fallout study was not an epidemiologic 
study, it's obvious that the same principles would apply to 
exposure assessment studies.
    The SPEERA panels' recommendations were based on the above 
principles. One of its recommendations was that representatives 
of populations whose exposures were being studied (and health 
officials who serve those communities) should be enlisted to 
serve on community level advisory committees. But perhaps its 
most important recommendation was for the creation of a new 
national advisory committee, to be established by the 
Department of Health and Human Services, that would oversee 
epidemiologic research. It was this recommendation that was at 
the core of the 1990 MOU between DOE and DHHS.
    Among the other developments that should have gotten the 
attention of NCI administrators were the findings and 
recommendations of the Presidential Advisory Committee on Human 
Radiation Experiments (ACHRE) in 1995. Although the Committee's 
primary concerns were the abuses involved with the use of human 
subjects in radiation experiments, it also commented critically 
on how the culture of secrecy within the former Atomic Energy 
Commission led to the suppression of information involving 
exposures to the public from secret emissions at Hanford and 
other AEC facilities.
    ``Where citizens are exposed to potential hazards for 
collective benefit,'' the Advisory Committee observed, ``the 
government bears a burden of collecting data needed to measure 
risk, of maintaining records, and of providing the information 
to affected citizens and the public on a timely basis.'' [2]
    Moreover, the ACHRE panel recommended the following with 
regard to future knowledge of environmental exposures:
    ``[the Administration] together with Congress, [should] 
give serious consideration to amending the provisions of the 
Radiation Exposure Compensation Act of 1990 to encompass other 
populations environmentally exposed to radiation from 
government operations in support of the nuclear weapons 
program, should information become available that shows that 
areas not covered by the legislation were sufficiently exposed 
that a cancer burden comparable to that found in the 
populations currently covered by the law may have resulted.'' 
(ACHRE Recommendation No. 5).
    The reforms proposed by the SPEERA panel in 1990 are today 
being implemented through the MOU between DHHS and DOE, with 
cooperation from the Agency for Toxic Substances and Disease 
Registry (ATSDR). Thus far, local or regional public advisory 
bodies have been established at the Hanford, Fernald (Ohio), 
Savannah River (South Carolina), and Idaho National Engineering 
& Environmental Laboratory sites. Similar public advisory and 
oversight bodies have been created by agreements between the 
Department of Energy and the states of Tennessee and Colorado 
to examine health issues surrounding the Oak Ridge and Rocky 
Flats sites respectively.
    While these community-based advisory bodies do not 
guarantee a seamless resolution to the health issues and 
concerns around these facilities, they do allow a truly 
revolutionary opportunity for public involvement that simply 
did not exist before the 1990 MOU. This is the way democracy 
should work to resolve longstanding issues and grievances that 
exist between a government and its people. This may seem like a 
messy and inefficient approach for some scientists and public 
officials but we've seen the alternative and know it hasn't 
served us very well.
    Given the strides we've made in communities around DOE 
facilities to begin dealing openly with the unresolved public 
health issues related to historic emissions and waste practices 
at these facilities, the complete failure of the NCI to notify 
and involve the public and public health officials in its I-131 
fallout study is staggering. In my view, it represents a major 
setback for public trust and confidence in what has otherwise 
been a commendable effort by DOE and DHHS in recent years.
    Spokespersons for NCI have suggested that the delay in 
releasing the results of the NCI I-131 fallout study was due to 
the fact that it is a large study and that researchers needed 
to make sure the exposure estimates were both thorough and 
correct.
    The problem with this explanation is that it isn't just the 
quality of the science that matters. It wasn't just livestock 
and gummed film sample plates that were exposed to the 
radiation NCI was asked to analyze. It was people. At some 
point in the course of this study NCI researchers and officials 
knew, or had reason to know, that thousands of American infants 
and children had received thyroid doses that were orders of 
magnitude greater than Congress and the American people had 
been led to expect. [3] At the very least, this knowledge 
should have led NCI to begin alerting and consulting with 
federal and state public health authorities, especially those 
responsible for public health in the areas hardest hit by the 
fallout.
    Why NCI chose not to take this course is a matter of great 
concern and one for which the Subcommittee should seek a 
thorough explanation and accounting.
    In conclusion, I would like to propose that the 
Subcommittee and Congress consider the following steps in 
response to NCI's mishandling of the I-131 fallout study.
    Consistent with the intent of the 1990 (and the 1996 
update) of the MOU between U.S. DOE and DHHS, the National 
Cancer Institute's radiation research projects--both domestic 
and foreign--should be brought under the purview of the HHS 
Advisory Committee on Energy-Related Epidemiologic Research. 
This reform could be accomplished by a reorganization of an 
open, accountable, and effective radiation health research 
program within DHHS that would no longer be dependent upon 
funding support from the Department of Energy.
    This could be accomplished legislatively by replacing the 
MOU with a law establishing a consolidated DHHS program charged 
with conducting and coordinating federal research on the public 
and occupational health effects of exposures to ionizing 
radiation and other hazardous exposures related to nuclear 
weapons production, testing and nuclear facility operation. The 
program should have its own line item in the DHHS budget. Under 
this initiative the charter of the HHS Advisory Committee on 
Energy-Related Epidemiology should be amended and clarified. As 
part of this reform, it should be clear that the radiation 
health program that remains at the Department of Energy is 
limited to those activities directly necessary to monitor the 
exposure and to provide for the daily occupational health needs 
of DOE employees, and DOE contractor and subcontractor 
employees. All health studies of these workers should be done 
through HHS. All international research--such as the current 
Chernobyl studies NCI is conducting with DOE funds--should be 
commissioned and funded through HHS and be accountable through 
HHS processes. This change should provide better accountability 
and enhanced credibility to the research.
    If, for whatever reason, a legislative reform is not 
enacted, an Executive Branch reform could be accomplished by 
revising the Advisory Committee's charter (which is up for 
renewal in February) and having the charter signed by the 
Secretary of DHHS. At the very least this involves amending the 
``Function.'' description in the ACERER charter to read:
    ``The (ACERER) shall advise and make recommendations to the 
Secretary of DHHS, the Secretary of Energy, the Assistant 
Secretary for Health of the Department of Energy, the Director 
of the Centers for Disease Control and Prevention, the 
Administrator of the Agency for Toxic Substances and Disease 
Registry, and the Director of the National Cancer Institute, on 
the establishment of the federal research agenda pertaining to 
energy-related exposure and epidemiologic studies.''
    Whether by legislation or by Executive Branch reform, it is 
important the change be accompanied with a commitment from NCI 
to participate with and be accountable to the Advisory 
Committee. The NCI Director should be asked to designate a 
high-level NCI official to be the liaison with the ACERER and 
this liaison should commit to attending all regular ACERER 
meetings and participating in the fashion that CDC, NIOSH, DOE 
and ATSDR now participate in that process.
    NCI should be given a deadline (within 30 days) to review 
the reports of the 1995 Presidential Advisory Committee on 
Human Radiations Experiments (ACHRE) and the 1990 Secretarial 
Panel for the Evaluation of Epidemiologic Research Activities 
for the Department of Energy (SPEERA), and from that review 
propose a set of guidelines for public oversight, public 
participation, and external peer review of NCI radiation health 
studies that reflect the findings and recommendations of both 
bodies. These guidelines should include language that requires 
public notification and a public advisory process in 
circumstances where there is known to be, or discovered to be, 
exposures that pose a significant threat to public health. 
These guidelines should be proposed to the Secretary of Health 
and Human Services and should be reviewed by the ACERER.
    In addition, there are at least two non-policy initiatives 
that should occur as a result of the long-delay in releasing 
the fallout data.
    The General Accounting Office should be asked to 
investigate and report back to Congress on such issues as why 
the NCI failed to act on evidence indicating large numbers of 
Americans received very high exposures, why the committee 
advising NCI on the risk implications of the data was 
disbanded, etc.
    In preparing this report, GAO should be asked to provide 
its own set of recommendations along with its findings.
    NCI should agree to support a process whereby CDC and the 
Agency for Toxic Substances and Disease Registry convene a task 
force to examine the fallout data--including other 
radionuclides such as strontium-90 and cesium-137--the risk 
estimates, etc., and make recommendations to the Secretary of 
HHS with regard to the education, medical monitoring, and 
medical assistance steps necessary to adequately respond to 
this information. This process should be coordinated with the 
ACERER and should include some ACERER members as well as 
representatives from state and county health departments, 
citizen organizations with a history of interest in these 
issues, other citizens who were exposed and who are 
representative of exposed groups, and relevant medical experts. 
It would also be wise to have DOE participate in this process 
because, at the very least, they hold information that is 
likely to prove valuable to the task force.

                               References

    [1] Report to the Secretary, The Secretarial Panel for the 
Evaluation of Epidemiologic Activities for the U.S. Department 
of Energy, March 1990.
    [2] Final Report of the Advisory Committee on Human 
Radiation Experiments, 1995. Finding No. 19.
    [3] The National Cancer Institute Study: ``Exposure of the 
American People to Iodine-131 from Nevada Atmospheric Bomb 
Tests,'' DRAFT memo, U.S. Department of Energy, July 29, 1997. 
p. 3.

                             FOLLOWUP STUDY

    Senator Specter. Mr. Connor, again, to the extent that your 
prepared statement does not specify what you think ought to be 
done by way of a followup study, the subcommittee would 
appreciate it if you would give us a written precise statement 
as to what you think ought to be done.
    Mr. Connor. I believe those are in my written comments to 
the subcommittee.
    Senator Specter. Thank you very much.
    Senator Murray. Mr. Chairman.
    Senator Specter. Senator Murray.
    Senator Murray. I have not made any statement yet. Mr. 
Connor is from my State and I just want to have the opportunity 
to thank him for coming and let you know that he speaks on 
behalf of many Washington State citizens. I am the daughter of 
someone who grew up in the Tri-Cities area, next to the Hanford 
Nuclear Reservation.
    I heard you talk, Dr. Beyea, about expanding the studies 
beyond thyroid cancer. My father had multiple sclerosis, as do 
a large number of people in eastern Washington and Idaho, and 
no one has ever been able to connect that to radiation fallout. 
But I do think the points being made are absolutely essential--
that people have a right to know, that people need the 
information that we have a responsibility to help those people, 
is absolutely essential.
    Senator Specter. I quite agree, Senator Murray.

STATEMENT OF ANDREA McGUIRE, M.D., STAFF PHYSICIAN, 
            VETERANS ADMINISTRATION HOSPITAL, DES 
            MOINES, IA
    Senator Specter. We now turn to Dr. Andrea McGuire, 
physician at the Veterans Administration Hospital in Des 
Moines, a graduate of Creighton University Medical School. Dr. 
McGuire has seen many patients concerned about their fallout 
exposure.
    Thank you for joining us, Dr. McGuire, and the floor is 
yours.
    Dr. McGuire. Thank you, Senator Specter, and thank you, 
Senator Harkin, for inviting me.
    I am a nuclear medicine physician practicing in Des Moines, 
IA. My profession involves the diagnostic and therapeutic use 
of radioactivity and the treatment and diagnosis of thyroid 
cancer. It is with this knowledge and my own personal knowledge 
that I come to this committee today.
    My interest in this subject has been increased beyond my 
professional interest by some medical events that have happened 
over the last 12 years to my family. Several years ago my 
brother-in-law had a nodule found in his thyroid on routine 
examination. After further evaluation with imaging studies, 
there was suspicion this was thyroid carcinoma and therefore he 
underwent a needle biopsy.
    At that time it was found to be thyroid carcinoma and he 
had a total thyroidectomy, which involves an incision across 
the neck and dissection of the thyroid gland. He then underwent 
thyroid ablation with radioactive iodine-131 and has routine 
followup to make sure he does not have recurrence of his 
disease.
    Not long after my brother-in-law's diagnosis, my sister-in-
law also found a nodule in her thyroid. She too has been found 
to have thyroid cancer and has undergone a total thyroidectomy. 
Just recently, another one of my sisters-in-law has found a 
nodule and has undergone a total thyroidectomy for thyroid 
cancer.
    When I first became aware of the results of the fallout 
study, I understood that some areas in Iowa had higher doses 
than others. When I discussed this with my mother-in-law, she 
told me that she had lived in one of these areas during the 
time when these children that had been exposed to this, when 
they were young, and they have gotten the thyroid cancer since.
    They also were on a farm at this time and drank cow's milk, 
which would increase their dose instead of getting milk from 
the dairy.
    It worries me and concerns me that three of my husband's 
family out of seven, all in the immediate age with each other, 
have gotten thyroid cancer and would have gotten the highest 
dose from this radiation fallout. As a physician, I am 
concerned because I take care of these patients and I am not 
sure what to do for them. Should I have a higher suspicion when 
they come in the door if they have been in one of these areas?
    I have heard a lot of information here today, but frankly 
in my practice I have not heard this information. I am not sure 
what to do as far as should I do more studies on these people 
because they will have a higher incidence? We have the external 
beam evidence that shows that there is a higher incidence in 
those patients. In those patients we were very good about 
making sure they have more testing and that we make sure that 
they do not get lost in the system and that we make sure they 
do not have thyroid cancer. Should we be doing that on these 
patients?
    I just do not have any information, Senators, to tell my 
patients what they should do or tell my siblings what they 
should do, and this concerns me greatly.

                           PREPARED STATEMENT

    In summary, the committee has the ability to give the 
physicians the information they need so that I can go to my 
patients and tell them what they need to hear: whether there 
are risks to people who are in the higher dose areas, what 
screening needs to be done for these patients, are there 
studies that say that there is an increase, and how we should 
proceed to keep a higher cure rate for thyroid cancer in this 
country.
    Thank you.
    [The statement follows:]

                Prepared Statement of Dr. Andrea McGuire

    My name is Dr. Andrea McGuire. I would like to thank the 
committee for inviting me to participate today. I am a Nuclear 
Medicine physician practicing in Des Moines, Iowa. My 
profession is involved with the diagnostic and therapeutic use 
of radioactivity. This includes many patents being diagnosed 
and treated for thyroid carcinoma. The radioactive fallout in 
the 1950's and the resultant radioactive contamination in Iowa 
affects many of my patients. I am also a mother, and wife and 
sister to people affected by this radiation fallout.
    My interest in this subject has been increased beyond my 
professional interest by some medical events that have happened 
over the last 12 years in my husband's family. Several years 
ago my brother-in-law had a nodule found in his thyroid on a 
routine examination. After further evaluation with imaging 
studies, there was suspicion this was thyroid cancer and, 
therefore, he underwent a needle biopsy of his thyroid nodule. 
This showed thyroid carcinoma and my brother-in-law underwent a 
total thyroidectomy which involves an incision across his neck 
and the removal of the thyroid gland. He then underwent thyroid 
ablation with radioactive I-131. He continues on lifetime 
replacement of thyroid hormone as well as continued yearly 
follow-up of his disease for recurrence. Not long after my 
brother-in-law's diagnosis with thyroid cancer, a physician's 
examination revealed that a nodule was present in my sister-in-
law's thyroid. She also was eventually diagnosed with thyroid 
cancer and underwent a total thyroidectomy and similar medical 
procedures and additional treatments due to spread of her 
disease. Recently, another one of my sisters-in-law was 
diagnosed with thyroid cancer and underwent a total 
thyroidectomy.
    When I first became aware of the results of this study of 
radioactive fallout and that some areas in Iowa had received 
somewhat higher doses than others I discussed with my mother-
in-law where my husband's family was living at the times of 
these fallouts. She informed me that at that time their family 
had been living in an area with the higher levels. After 
further discussion, I discovered that at the time of the 
fallout her three children that now have thyroid cancer were 
under the age of 5 years old. This is important for two 
reasons: one, the amount of milk young children drink is much 
greater than that which older children and adults consume and 
two, the thyroid is thought to be more sensitive to radiation 
effects at this younger age. She went on to tell me that at 
that time they all lived on the farm and drank milk from their 
own dairy cow. This is important because typically the milk 
that goes to a dairy is consumed approximately 14 days from 
when it is milked from the cow. But these children drank the 
milk within 12 hours from when it was milked from the cow.
    With I-131 having an 8 day half-life, this would have given 
them approximately 4 times the dose of people who consumed milk 
from the dairy. As a physician and scientist, I realize that 
there is no definite evidence that my family's thyroid cancers 
are related to the exposure they received as children. However, 
the fact that the three children who received the higher doses 
because of their location at the time of the nuclear test, 
their age, and their ingestion of cow's milk have all had 
thyroid cancer but none of their siblings that were not of that 
age or received the cow's milk have cancer is of concern to me.
    Are their other examples out there?
    I have tried to obtain more information about the study 
since that time and have not been very successful. Iowa state 
cancer registry finds an increase in thyroid cancers from 1.7 
cases per 100,000 in 1973 to 3.4 cases per 100,000 in 1995. The 
registry states that many cancers have increased over this time 
and that this is most likely from early detection. My concern 
is that in this small example of my family none of them were 
diagnosed or treated for the thyroid cancer in the geographical 
area in which they were exposed and only one of them was 
diagnosed and treated in Iowa. Therefore, I am concerned that 
on a state basis it may be difficult to evaluate these 
statistics.
    This brings me to my second reason for concern over this 
fallout issue. What do I tell my patients and my other family 
members regarding areas that have this increased radioactive 
fallout? Patients come to see their doctor to get answers and 
to understand what is happening to them. I don't have enough 
information to tell them. If they were living in these areas 
known to have a higher rate of radioactive fallout, what should 
they do? Should they have their thyroid examined? Should tests 
be run? Should they have scans of their thyroid? It is 
difficult to be their adviser when I have so little 
information. It is known that external beam radiation which was 
given to young patients in the neck area for various reasons 
such as acne or an enlarged thymus have a higher incidence of 
thyroid cancer. Physicians use this piece of information when 
evaluating patients. This is because these patients with a 
history of external beam radiation to the thyroid typically 
receive screening for thyroid cancer because of this higher 
incidence. On the other hand, as a physician I have no idea 
whether this should be true for patients exposed in the higher 
areas of radiation fallout. We do know that the thyroid is a 
very radiation sensitive organ and that I-131 does give off a 
relatively high radiation dose to the thyroid because of the 
thyroid's ability to concentrate iodine. Because of the lack of 
information about the fallout, I don't know whether I should be 
more suspicious when examining their thyroid? Should I order 
additional imaging tests on these patients as I most likely 
would on patients exposed to external beam radiation? Should I 
follow them more closely than a routine patient? I need for you 
to understand that this lack of information makes me a less 
effective physician to my patients, and therefore, I am here as 
an advocate for their health. I also worry about people who do 
not receive routine medical care. What should be done to 
evaluate these people.
    I also know that I don't want patients alarmed 
unnecessarily. In adults, the incidence of thyroid nodules is 
between 4 to 7 percent. This incidence tends to increase with 
age and is greater in women. The vast majority of these nodules 
are benign in nature and need no further evaluation. I can 
appreciate the problems that could be created and the 
unnecessary procedures that might be performed if this 
situation is not handled properly.
    In summary, this committee has the ability to give 
physicians and patients the information they need. What are the 
risks for people who were exposed to radioactive fallout? Do 
the risks differ depending on factors such as location, age, 
and ingestion of cow's milk? Has an increased incidence of 
thyroid cancers been studied? What is the best way for 
physicians to screen these patients if they are at higher risk? 
Please do the necessary studies and disseminate the appropriate 
information to physicians and patients so we can use our 
medical knowledge to continue to have a greater than 95 percent 
cure rate for thyroid cancer.

                                 TESTS

    Senator Specter. Thank you very much, Dr. McGuire.
    Dr. Lyon, your charge is a very serious one, that you would 
not trust the NCI or the administration to carry out these 
tests. I appreciate the fact that you have had very extensive 
experience in the field. Can you tell us why you would not, in 
effect, trust NCI here?
    Dr. Lyon. Well, at least under the current administration, 
under the constraints placed on by Federal contract----
    Senator Specter. When you say ``under the current 
administration,'' could you be specific?
    Dr. Lyon. Well, I say the current siting of radiation 
studies at NCI.
    Senator Specter. Are you talking about Dr. Klausner?
    Dr. Lyon. No, Dr. Wachholz's group, who has the radiation 
studies responsibility.
    Senator Specter. Why do you say that about that group?
    Dr. Lyon. Well, because of the long past history on the 
earlier Utah study, where we had the continued, continued 
problems that I've detailed in my testimony.
    Senator Specter. Dr. Klausner, are they here today?
    Dr. Klausner. Yes.
    Senator Specter. Go ahead, Dr. Lyon.
    Dr. Lyon. The other big concern is that there is no 
commitment to any kind of public involvement in terms of 
citizens advisory committees, informing the public of the 
results. I have been beat up, beat up verbally, in meetings 
with physicians and southwestern Utah on inconclusive results. 
I have had videotapes played to me by various interviews given 
by officials in the Federal Government saying it's 
inconclusive, there is no effect. This is an area where we know 
we have got people with radiation exposure of over 400 rads to 
their thyroid. The physicians have never been informed of that, 
and they have been told that the findings are inconclusive and 
that there is no cause for concern.
    There was no effort to create any kind of a public group, 
any kind of a medical group that could even look at that. There 
has certainly been no medical surveillance within the area, and 
there was no willingness on the part of the NCI to even 
consider those kind of public health-oriented programs.
    For this reason, I think continued work without heavy 
public involvement is simply going to be fruitless.
    Senator Specter. Dr. Klausner, we will give both you and 
the individuals who have been identified by Dr. Lyon a chance 
to respond. Dr. Lyon's written statement is very forceful. It 
says: ``I was appalled to find that employees of one of the 
premier research institutions in the world, the National Cancer 
Institute, in August of 1997, just a month ago, were using the 
same tactics that had been used for the last 40 years by 
officials of other Federal agencies. And even more upsetting to 
me was that these tactics had been used to obfuscate their own 
research findings of potential excesses of thyroid cancer for 
many citizens of the United States.''
    He also complains about the delay in releasing the 
findings, and then at page 11 he says: ``Use of the term 
`inconclusive' to describe our thyroid study is disingenuous. 
We found a threefold increased risk between childhood exposure 
to radioactive iodine and subsequent thyroid neoplasms, with a 
clear dose relationship. Certainly no researcher would consider 
exposing a group of children to radioactive iodine based on 
such a finding.''
    Dr. Klausner, how do you respond to that specific 
scientific finding of a threefold increase and his statement 
that he thinks it is disingenuous? Pretty tough criticism.
    Dr. Klausner. Yes, it is, although it surprises me because 
we have stated their finding, and just simply quoting their 
publication, that they showed a 3.4-fold increase. It 
represents, as they said, a difference of between 0 and 8 
thyroid cancers and, as they said, because the range was 
between 0 and 8, the standard scientific and medical response 
to that is that there is some uncertainty about what the actual 
rate is.
    But we said that the point estimate, as they pointed out 
and I have quoted them, was a 3.4-fold increase. We are not 
trying--I am not sure why there is a perception that we are 
trying to downplay this.
    I must say I highly agree with Mr. Connor, that we need to 
move to make sure that these sorts of studies--and we have been 
doing that--have public oversight. What I have tried to do as 
the new director of the NCI is, as I learned about this study, 
to move to completely disclose it, to disclose all the 
information, make it accessible to everyone.
    We have a very extensive communications dissemination plan 
with the CDC. We are developing a new memorandum of 
understanding with the CDC for all of our radiation studies. I 
think these points are very well taken, but I am not sure what 
I can do about the past other than work very hard to try to fix 
these things, and that is what we have done.
    Senator Specter. Before we turn to Senator Harkin, I will 
give you a chance to respond, Dr. Lyon.
    Dr. Lyon. I just want to make one quick comment, that one 
of the concerns was we had inconclusive findings. We recognized 
that. Any rational researcher asks for additional years of 
followup, because these people were just coming into their 
period of highest risk.
    The games that were played with our grant application were 
appalling.
    Senator Specter. What do you mean, ``games that were 
played,'' Dr. Lyon?
    Dr. Lyon. Essentially, after getting the grant funded, 
someone went to the Board of Scientific Counselors, shares 
information with them not in the grant application, and the 
grant is put on hold. We were never given a response, 
opportunity to respond. The grant is then bounced around from 
institute to institute until finally it dies.
    We have requested on separate occasions through our 
congressional delegation some effort to try to get funding for 
it, and the message comes back: This is of no scientific 
interest, it has very low priority within the HHS structure.
    It bothers me that when you have an inconclusive finding, 
you know it is inconclusive and have a way to fix it, and it is 
the important public health question that it is simply buried 
within the bureaucracy of the HHS and you are told that it is 
of limited scientific interest to the citizens of the United 
States.
    Senator Specter. What about that, Dr. Klausner?
    Dr. Klausner. I just completely disagree. We have been 
asking--I have been asking about, should we not do a followup 
on this? The process by which grants come in, is that they do 
not come in to the Institute. They come in to the NIH, they go 
to the Division of Research Grants.
    The Division of Research Grants actually, as I understand, 
sent that to NIDDK. You were puzzled about that, but that 
Institute is the Institute that oversees thyroid studies.
    Dr. Lyon. It actually went to NIEHS, then was bounced to 
NIDDK.
    Dr. Klausner. I am sure these are complicated processes and 
I am happy to look into it.
    Senator Specter. Dr. Klausner, are you aware of the 
specifics Dr. Lyon is talking about?
    Dr. Klausner. No, sir; I am not aware of the specifics.
    Senator Specter. I am just interested in what the facts 
are.
    Dr. Klausner. I am not aware of the specific allegation 
that someone interposed and interfered with the process of peer 
review or of granting. But it is not true that we are not 
interested in funding followup to this. In fact, I must say we 
have been discussing numerous times over the last several 
months how interested we are in the opportunity to follow up 
the Utah cohort study.
    Senator Specter. Well, would you provide the subcommittee 
with those specifics?
    [The information follows:]

                       Funding Research Projects

    During the October 1 hearing regarding the report of the 
National Cancer Institute (NCI) on exposure of Americans to 
radioactive fallout from the Nevada Test Site, Dr. Joseph L. 
Lyon (University of Utah) alleged that Dr. Bruce Wachholz 
(Chief, NCI's Radiation Effects Branch) intervened in some way 
to influence the decision not to fund Dr. Lyon's research grant 
application on thyroid disease resulting from exposure to 
radioiodines. These same allegations were made in a recent 
article that appeared in Nature. These are very serious 
charges.
    The application referred to by Dr. Lyon was titled, ``A 
Cohort Study of Thyroid Disease from Radioiodines.'' The 
original application was submitted to NIH in 1987 and assigned 
to the National Institute of Environmental Health Sciences 
(NIEHS). It was reviewed by the Epidemiology and Disease 
Control Study Section (Subcommittee 2) in February/March 1988. 
The application received a priority score outside the funding 
range for NIEHS that year, so Dr. Lyon revised the application 
and resubmitted it, this time receiving a priority score within 
a fundable range. However, the application was given a 
``Council Deferral'' at the February 1989 NIEHS council meeting 
so that further information could be gathered.
    At issue was the high cost of the study; whether other 
studies addressed the research question; and maintaining 
program balance within the NIEHS grant portfolio. As is done in 
the normal course of determining whether scientific overlap 
exists between two projects, NIEHS staff contacted Dr. 
Wachholz, who was the project officer on an NCI research 
contract to Dr. Lyon at that time, to determine if there was 
any scientific overlap between the NCI contract and Dr. Lyon's 
most recent grant application. Dr. Wachholz provided the 
necessary information about the work scope of the NCI contract, 
in a manner that is recalled by NIEHS staff as having been both 
thorough and objective.
    NIEHS made the evaluation as to whether there was 
scientific overlap between the ongoing contract and the grant 
application. Subsequently, it was decided by the Director, 
NIEHS, not to fund the application. Dr. Lyon later submitted a 
revised application on the same topic which did not receive a 
fundable score. However, Dr. Lyon did have a grant funded by 
NIEHS during this time period entitled, ``Radon Progeny and 
Risk of Lung Cancer.'' The project period for this grant was 
from September 1, 1988 to August 31, 1995.

                       FOLLOWUP STUDIES NOT MADE

    Senator Specter. Senator Harkin.
    Senator Harkin. Thank you, Mr. Chairman, and I appreciate 
your line of questioning. I think it kind of gets to the heart 
of this. That is, we need to understand the past and why this 
information did not get out and why followup studies were not 
done. But I think to cut through it now and start looking at it 
and get the followup studies done as soon as possible--but 
there are people out there who are now in their forties, 
fifties, sixties, and if you are going to study it for another 
20 years, we do not have that time.
    So it seems to me that we have a lot of information already 
on which we can make rational, informed decisions on 
information to practitioners and to public health agencies and 
to the citizenry at large as to what they ought to do. I do not 
know why we cannot cut through this and get this job done.
    What I hope we can do here, Mr. Chairman, is to consider 
how we bring together NIH or NCI as a part of NIH, the Centers 
for Disease Control and Prevention, and the U.S. Public Health 
Service in a working group to decide what basis do we have to 
go on from the studies we have done. We have done a lot of 
studies. And what can we do to take that information and get it 
out as soon as possible.
    I have been informed, Dr. Klausner--I noticed this over the 
last few months--that the increase in the use of Synthroid in 
this country has just skyrocketed in the last 10 to 15 years. 
Why is that? Why are so many hundreds of thousands of people 
now taking Synthroid?
    Can I just throw that out and ask for one of you doctors or 
someone to respond to that? Do we know? Anybody?
    [No response.]
    Senator Harkin. I feel like that guy in ``Ferris Buehler's 
Day Off'': Anybody?
    Dr. Beyea. I think it is premature to leap to conclusions 
as to what the cause is, but I do know this, that we explored 
the possibility of talking to the manufacturers and giving us 
the statistics on the increase in sales by county. I could not 
afford to do it, but it could be done. One could get those 
statistics for every county in the United States, match them 
up, correlate the increase in that drug, and it is a very 
useful thing to do.
    Senator Harkin. Why does a doctor prescribe Synthroid to a 
patient?
    Dr. Klausner. Overwhelmingly, the reason that a doctor 
prescribes Synthroid is to treat hypothyroidism. Now, there are 
many different ways in which people assess whether someone is 
hypothyroid. One of the issues and controversies is the 
definition of when a person is hypothyroid or slightly 
hypothyroid and when they might benefit clinically from thyroid 
replacement.
    Senator Harkin. And would they also prescribe Synthroid if, 
on giving an exam, they felt nodules?
    Dr. Klausner. No; they should certainly not do that.
    Senator Harkin. That is what was prescribed for me by a 
doctor.
    Dr. McGuire. It depends.
    Senator Harkin. Pardon?
    Dr. McGuire. There are people with goiters or nodular 
thyroids that are put on Synthroid at times.
    I have one question. When he was talking about----
    Senator Harkin. I do not understand this. I have been 
taking Synthroid for 17 years and I have been taking it because 
I had nodules on my thyroid, and I have more nodules on my 
thyroid. And I am just wondering why. You all say no, doctors 
would not do it.
    Dr. Klausner. Not automatically. That is often a correct 
thing to do. What happens is the Synthroid is given and that 
reduces the stimulus that is released from the brain for your 
thyroid to grow. So the idea is that then that would reduce the 
possibility of the nodules.
    Senator Harkin. It is possible that doctors are prescribing 
Synthroid because they feel nodules on a thyroid?
    Dr. Klausner. Absolutely.
    Senator Harkin. Thank you.
    Dr. Beyea. They also may prescribe it because they are 
seeing an increase in hypothyroidism. They also may be seeing 
that as well.
    Senator Harkin. That is true.
    Well, again, the reason for that line of questioning for me 
is that chart that you held up, you Dr. Beyea, that shows that 
perhaps there is more happening out there than just cancer. Why 
are so many people taking Synthroid? They did not 20 years ago, 
they did not before that. But now all of a sudden it has 
skyrocketed.
    Dr. McGuire. Senator, if I may. They were talking about a 
county, looking into where Synthroid was or looking into more 
thyroid cancers in different areas. One concern I have is that 
in Iowa there has been an increased incidence of thyroid cancer 
and that may have been caused by many things, one of them 
possibly this. But of my relatives, the Iowa registry would 
have only known of one of them, because only one of them was 
still living in Iowa, and then in a different part of Iowa, 
when she was diagnosed.
    Senator Harkin. See, that is a problem.
    Dr. McGuire. So I am not sure State registries are going to 
be very helpful in this area.
    Senator Harkin. That is true. From my own personal case, 
someone living in Pennsylvania getting thyroid cancer who grew 
up on a farm in Iowa.
    Dr. McGuire. Exactly.
    Senator Harkin. How do you know?
    Dr. McGuire. Exactly.
    Senator Specter. Senator Harkin, let me just make an 
interjection and I will yield back in just a minute. I am going 
to have to excuse myself for this next session, but we will be 
following up. We are going to yield to Senator Craig in a few 
moments, who may be able to stay longer. Of course, he has not 
had his round yet.
    But we are going to pursue these matters. This subcommittee 
is going to pursue the details as to what Dr. Lyon has said as 
to what has happened on the NIH grant application. We want to 
get very specific and know exactly what happened and who is 
right and who is wrong. This ought to be subject to our 
determination, because these are very serious charges about 
this administration of NCI being unable or--let me use a 
moderate word--inappropriate or not up to doing this job, 
considering the $2.3 billion which we are appropriating again, 
plus, for NCI.
    We will go into the details as to what has been testified 
about the cover-up in the past. As a result of what we see 
here, we may schedule additional hearings of the subcommittee.
    Senator Harkin, I yield back to you. At your conclusion, 
Senator Craig, if you would proceed to chair the hearing. Thank 
you.
    Senator Harkin. I appreciate that very much, Mr. Chairman. 
I think we may have to have some follow-up hearings on this.
    Let me just again, Dr. Klausner, if I might ask: In terms 
of public involvement, since we are on that topic right now, 
there is currently in place some mechanism to ensure public 
accountability in health studies. Dr. Klausner, did the study 
research team have contact with the HHS Advisory Committee on 
Energy-Related Epidemiological Studies, often referred to as 
ACERS?
    Dr. Klausner. I think this is the committee that--I am not 
sure what the exact interactions were between that committee. 
Is this the committee, Mr. Connor, that you are on?
    Mr. Connor. Yes; here is your letter.
    Dr. Klausner. So in 1996 I received a letter from Mr. 
Connor asking about the overall activities of the NCI in 
radiation-related studies. And this was transferred to the 
staff, the appropriate staff, to respond. What happened, and 
this was a problem, there were two, at least two, different 
groups in two different divisions of the NCI that were doing 
these studies. This was sent to one division and a collection, 
a description of studies were sent, but it did not include this 
study because it was in a different division. That was a slip-
up.
    That was recognized later and then the information about 
this study was transferred, as I understand.
    There was, I gather, appended to this letter a resolution 
that the committee had agreed upon in April of 1996, if I have 
this right, to gather more information about the I-131 study. 
That appended resolution was not referred to in the letter, and 
again it was an oversight. When the individuals involved in the 
study received an invitation to speak to this committee, that 
was arranged, and they will be doing that at the next meeting.
    Senator Harkin. Let me understand. My staff tells me we 
have two members of the committee here. Are you a member of 
that committee, Dr. Connor? ACERS, it is called?
    Mr. Connor. Yes.
    Dr. Lyon. And I, too, am.
    Senator Harkin. I did not know who they were. Advisory 
Committee on Epidemiological Radiation Studies, referred to as 
ACERS. My staff tells me that this HHS-chartered body was 
established as a step to ensure oneness and to help coordinate 
between various research teams.
    Again, I just want to know, did the study research team 
have--I will ask you the same question. I am trying to get 
through it. Did they have contact with this group, ACERS?
    Mr. Connor. There is one letter that exists between Mr. 
Wachholz and Jim Smith, the head of radiation studies at CDC. 
It is a several-page letter and that is the contact, and it is 
just very unfortunate.
    Senator Harkin. When was ACERS set up? What year was it?
    Mr. Connor. ACERS was set up--in my testimony I mentioned 
the 1990 memorandum of understanding between DOE and HHS. That 
memorandum of understanding calls for the creation of that 
advisory committee, which is supposed to oversee the Center for 
Environmental Health's activities and NIOSH's activities, to 
focus on Department of Energy facilities and DOE releases.
    So obviously one of the concerns of our committees was, 
here was a major DOE release and a study about these releases 
that we did not have access to. There was great concern on the 
committee from Dr. Lyon and others that the study was being 
suppressed, that the American people were not being told the 
magnitude of the doses that the researchers were finding in 
that study.
    We were very concerned about that. That was one of the 
reasons, not the only reason, but one of the reasons, we began 
to make overtures to NCI to have a dialog and eventually get 
this material out to the American people.
    Senator Harkin. Dr. Klausner, does NCI consider itself 
under the jurisdiction of ACERS?
    Dr. Klausner. I am told that this was not, this study was 
not considered under the jurisdiction of ACERS. I have since 
had discussions with Dick Jackson and Henry Falk from the CDC 
so that we can establish a memorandum of understanding, which 
we are doing now, so that we can completely share all the 
information of all the activities that the NCI is engaged in 
related to radiation.
    But my understanding is that this particular study was 
interpreted as not under the purview of ACERS.
    Senator Harkin. I am sorry to belabor this so long. I just 
do not understand why. I mean, it concerns the public health. 
It concerns the very reason why it was established, and that is 
to get information out to the public when we have these health 
studies. I do not understand that. I just do not, and I do not 
know what we have to do to make sure this does not happen 
again.
    Dr. Klausner. Well, this is what we are moving on. For a 
lot of this, I am in the position of----
    Senator Harkin. Who would have made that decision, Dr. 
Klausner, that NCI and this report was not under ACERS, that 
study?
    Dr. Klausner. Well, when I have spoken to the people at 
CDC, they tell me that they did not expect that this study 
would come under that jurisdiction, that the original 
memorandum of understanding covered the studies that were being 
moved from the DOE to the CDC, and the agreement as part of 
that movement was that there would be an oversight.
    So in the original charter, in the original memorandum of 
understanding, there was not the expectation. As I have queried 
the CDC officials to find out, well, where did this fall 
through the cracks, they said their expectation was that this 
was not under the purview of ACERS. Now, ACERS in this letter 
asks for information about that, and I think that is quite 
reasonable and that is why I have now moved to develop a 
separate memorandum of understanding between the CDC and NCI.
    Senator Harkin. So you say the basic responsibility lies 
with--if CDC had said yes, this should be under ACERS, that 
would have made all the difference in the world? Is that what 
you are saying?
    Dr. Klausner. Well, I assume that then that would have been 
brought to the NCI at the time as their interpretation of what 
should come under ACERS. That is the only thing I can surmise 
from trying to understand the past history.
    Senator Harkin. Do you have any observations on this, Dr. 
Lyon? You are a member of that committee.
    Dr. Lyon. My observations are more of an outsider, but the 
sense was when this memo was put in place that there were still 
other entities in the Federal Government that were pursuing 
their own interests in radiation research. I think particularly 
the Russian studies were viewed as an NCI preserve and did not 
come under this, and that some of the residual studies, such as 
this thyroid study, were pretty well considered.
    So there was very little effort made to try to even bring 
them under. We finally asked for a briefing on the matter.
    Dr. Klausner. Right.
    Senator Harkin. One last thing. Do you believe that we 
should encourage you to move ahead, Dr. Klausner, in studying 
the other two areas that Dr. Beyea spoke about? And that is the 
nodularities and the autoimmune thyroid diseases that have not 
been covered.
    Dr. Klausner. I think the NIH ought to consider that. As 
Dr. Beyea I think has pointed out, not all of this is under the 
expertise of the NCI, and I think that would be a problem. I 
think it is one of the reasons to try to move us to a new page 
where this is very public, and why we have asked for a rapid 
response from the IOM, so we can get a public hearing about 
where we stand now, what studies are going to need to be done, 
and, very importantly, to answer Dr. McGuire's most important 
concern: What information do we give, the ``we'' being the 
entire community, to health physicians, families, patients, 
communities, public health officials, to answer the questions? 
Not that we are going to have a perfect and definitive answer 
to everything, but the answers; as much as we can, we have the 
information there and it is available to everyone.
    I think that is the most important thing and that is what 
we are trying to do.
    Dr. McGuire. Senator, right now, I went to the Internet to 
try to get some information on this and called the 800 number 
for the NCI, and I was told basically that there was no 
problem, but if you were concerned you could go to your doctor. 
So that is not what I am hearing here, so we definitely need to 
get some information out.
    Senator Harkin [reading]:

    Even then, the number of children and grandchildren with 
cancer in their bones, with leukemia in their blood, or with 
poison in their lungs might seem statistically small to some in 
comparison with natural health hazards. But this is not a 
natural health hazard and it is not a statistical issue. The 
loss of even one human life or the malformation of even one 
baby who may be born long after we are all gone should be of 
concern to us all. Our children and grandchildren are not 
really statistics toward which we can be indifferent.

    That is from President John F. Kennedy's speech on ending 
the above-ground tests in 1963.
    Senator Craig [presiding]. Senator, thank you.
    Let me turn to Senator Gorton, who has just come in and 
needs to be off to another committee. Senator.

                       REMARKS OF SENATOR GORTON

    Senator Gorton. Thank you. I simply wanted to welcome my 
constituent Mr. Connor here and say I am sorry. We are at the 
very end of coming up with the Interior appropriations 
conference report, but I have got to get back to that. But I 
have read his testimony. I am obviously very much aware of the 
concerns of the downwinders all over eastern Washington.
    I think the presentation he has made is a thoughtful one 
and the recommendations he has made are recommendations in the 
alternative, at least, one or the other ought to be adopted. I 
thank him for coming and sharing his experience and wisdom with 
the committee here today.
    Thank you, Senator Craig.
    Senator Craig. Senator Gorton, thank you.
    Questions of you, Dr. Klausner, and Dr. Lyon, and any of 
the rest of you who would wish to comment. You have heard the 
chairman and the ranking member speak of the frustrations that 
I think all of this committee shares as to the flow of 
information or the lack of flow or the unwillingness to provide 
factual information or in some instances the allegations of 
varying information.
    As this information emerged in August, I mentioned in my 
opening comments that four counties in my State appear at this 
moment to have experienced elevated levels of fallout. Under 
some weather scenarios, we are termed downwind of Nevada, and 
of course Nevada is a bordering State.
    Based on the current situation, the current knowledge, lack 
of knowledge, coverup of knowledge, the failure to disseminate 
and-or interpret, whatever it is we are trying to understand 
here--and I am not sure what it is yet--what do I tell the 
citizens of those four counties, Dr. Klausner, at this moment? 
What should they know? What should they expect to know in the 
future?
    Dr. Klausner. I think the citizens should know that they 
were exposed. They should know how to understand who was 
exposed and try to--it depends on how old you were. What is 
most important in the individuals who were exposed is children.
    I think the public health officials need to know. We have 
discussed with the public health officials of your State about 
getting information and disseminating information about thyroid 
cancer, about thyroid exams, about this study. We have been 
working with them. We will continue to work with them. We have 
asked them what their plans are in terms of monitoring and 
public health activities in all of the most heavily exposed 
States.
    As I said, there is and will continue to be--and this is 
very important--a tremendous amount of information and press 
coverage and awareness about this, to reawaken awareness that 
has sort of come and gone about radiation, to emphasize that to 
those areas. And those individuals should consult with their 
physicians.
    Our recommendation now, along with the American Thyroid 
Association, is that individuals who were exposed--and they can 
find out their exposures by looking at those maps and knowing 
what their ages were--should see their physicians, talk to 
their physicians, and what we recommend is a manual thyroid 
exam. Those remain, I think, the most reasonable interim 
recommendations until we get as rapidly as possible a set of 
broader national recommendations as to whether there are other 
recommendations in terms of public health or medical 
intervention or surveillance from the Institute of Medicine 
study.
    Senator Craig. Dr. Lyon.
    Dr. Lyon. I would agree with Dr. Klausner. I think that is 
a very responsible recommendation at this point in time. I do 
want to add one very brief comment that I hate to bring up, but 
one of the issues here is how is this going to be investigated 
from a public health standpoint, what specific types of 
scientific studies.
    Again going back into the earlier era, part of our fallout 
study in the 1980's included a case control study to examine 
the risk of thyroid cancer in northern Utah that would have 
been, we thought from the contamination, well outside the 
southwestern corner of the State. We were well into the study, 
developed the methodology, had not yet begun collecting cases, 
and we were given a Hobson's choice on our funding, which was 
basically you can do the cohort down in southwestern Utah or 
you can have the case control. We chose the cohort.
    I think in hindsight it is unfortunate, because that would 
have provided a methodology well worked out that could be 
applied to the rest of the United States. We probably can 
resurrect some of that material from our files and we had 
actually gotten to the point of writing a questionnaire and 
defining exposures, and this may be helpful in terms of getting 
fairly quick answers for what risk, what the actual risk may 
be, at least on a State by State basis.
    Senator Craig. Dr. Connor.
    Mr. Connor. Senator Craig, one of the things about the 
study that is most disturbing to me is that it was apparent 
that, much earlier than the past year, the researchers had the 
capacity to know where the highest risk people were. If I can 
read from--this is a paper that Mr. Wachholz wrote for the 
Journal of Health Physics in 1990 that was apparently based on 
an earlier presentation at a conference: ``Completion of the 
exposure and dosimetric segments of the study is anticipated in 
1990-91.'' Which indicates to me that, much earlier than the 
past year or two, that they have the capacity in-house and the 
understanding in-house, or should have had the understanding, 
to know where the people at highest risk were.
    Why did they not contact public health officials and engage 
in an immediate dialog to find out how they were going to 
contact those people and their physicians, if only the advice 
was, check with your physician on this at your next doctor's 
visit, have your thyroid examined? Those things were very basic 
things that could have happened, that could have made a 
difference in people's lives, perhaps have prevented longer 
illnesses or deaths. And it did not happen.
    I would encourage you to look at this to find out what in 
the protocol of NIH, NCI, prevented them from acting at that 
threshold. Again, at some point this ceased being a scientific 
study, when there was evidence to indicate that people were at 
substantial risk and that we had the means to locate them, 
perhaps not locate them directly in those counties, but knowing 
that they were in those areas at the time of the exposure.
    We have known who the vulnerable folks are. It is small 
children and particularly the females that were at the highest 
risk. Why were they not notified and why were they not given a 
chance to do more for their health?
    Senator Craig. Does anyone else wish to comment on that? 
Dr. Beyea?
    Dr. Beyea. I would just like to make one or two points. 
First of all, I do not want to--I hope the impression is not 
gotten across here that we have to do more scientific studies 
before we will know what kind of recommendations to make to 
medical health providers. There is a great deal of information 
already available that can do that. It may be that later 
studies will help refine those recommendations, but we do not 
have to wait for that.
    The other thing: I think you have a very difficult time, 
Senator, in telling your constituents as to what they should 
do. It seems to me I would feel in a very difficult position if 
I were in your place, because the Government could have done 
something a long, long time ago. They could have issued 
advisories in the fifties and the sixties. They could have had 
people not take fresh milk. They could have had farmers not 
feed fresh food.
    So I think that some apology is in order perhaps to the 
American public for what has gone on during that cold war 
period. We have to recognize that it was different times, 
different concerns. But there are still some things that were 
done that we probably will be ashamed of.
    Senator Craig. Let me conclude with this, because the 
American Thyroid Association has been mentioned. I am reading 
from a copy off their web page, and this is a press release, 
``Radiation exposure from past Nevada atomic bomb tests.'' The 
second paragraph: ``Radioactive iodine has been used for more 
than 50 years in almost 10 million individuals as part of 
routine thyroid function tests in amounts far greater than that 
delivered by fallout and careful long-term follow-up studies of 
these individuals have not shown any evidence of excess thyroid 
cancer attributed to radiation exposure.''
    Senator Craig. Is that inconsistent with what we are now or 
any of you are saying?
    Dr. Beyea. No, because you have to make a distinction 
between adults and children.
    Senator Craig. And therein lies the difference?
    Dr. Beyea. There lies the major difference. Now, you have 
to recognize that the ratios are enormously different. As an 
adult your risks are way, way down, maybe a factor of 10 times 
lower, than if you are a child.
    Plus I do not think the American Thyroid Association in 
this country is the last word on thyroid health effects. They 
after all, they are good doctors, they do good things. They do 
not want, I think----
    Senator Craig. The problem is the public might view them as 
the last word. They pack an official title.
    Dr. Beyea. That is right. But we have the various National 
Academy reports that are put out periodically. It is a problem 
that radiologists, particularly in this country, have a mind 
set that radioiodine is good for you, and in many cases it is 
good for you. If you have hyperthyroidism, radioiodine may be 
very helpful to you.
    But we can make that a choice. We do not have to have 
individuals be given that against their will.
    Dr. McGuire. Senator, typically as a physician, typically 
the family physician or internal medicine doctor is going to be 
the first person who is going to see a patient with a nodule, 
and I am not sure they are reading the American Thyroid 
Association's web page. So I think you are exactly right, that 
information needs to go through different channels.
    Senator Craig. Thank you.
    Senator, do you have any further questions?
    Senator Harkin. Senator, just a couple.
    Senator Craig. I will let you follow up and conclude and 
adjourn the hearing, if you would.
    Senator Harkin. I appreciate that, and I will very shortly, 
because I know staff has to get over to the conference 
committee, and so do I.
    I do have a question that Senator Daschle wanted asked. He 
has an intense interest in this, has expressed it to me 
personally, and he had a written question, which basically--I 
will just read a summary of it. He says:

    On July 27 I contacted you, Dr. Klausner, with four 
straightforward requests, all of them directed toward providing 
the public with the answers it was promised years ago and 
assuring that future public mandates will be handled with more 
accountability, responsiveness, and basic respect for the very 
real concerns of people exposed to the iodine-131 fallout.
    Specifically, I asked you to assess and report to the 
Congress about the apparent delays surrounding the study

    That is what we are talking about now----

    Take whatever steps are necessary to ensure that similar 
delays do not undermine future NCI projects, establish a date 
certain for the Institute of Medicine's evaluation of the 
appropriate medical response to the various exposure levels 
associated with the fallout, and to evaluate whether there was 
a significant change in the incidence of thyroid cancer in the 
wake of the nuclear testing, particularly in hot spot areas.

    Basically, he says: ``To my knowledge, you have not made 
appreciable progress toward fulfilling any of these requests.'' 
I believe some of that has been done here today, but would you 
please respond to Senator Daschle's questions that he wrote on 
July the 27. I will make that a part of the record.
    [The information follows:]
                 Letter From Richard D. Klausner, M.D.
           Department of Health and Human Services,
                             National Institutes of Health,
                                 Bethesda, MD, September, 30, 1997.
Hon. Thomas Daschle,
U.S. Senate,
Washington, DC.
    Dear Senator Daschle: Thank you for your letters to Secretary 
Shalala and to me pertaining to the release of the National Cancer 
Institute (NCI) study on the iodine-131 fallout from atmospheric 
nuclear weapons tests at the Nevada Test Site in the 1950's and early 
1960's. I hope the following information is helpful.
    We at NCI share your concern that the information available in this 
report be made available to the public as soon as possible. Our 
objective has been to provide the report in its entirety (several 
hundred pages of descriptive text and mathematical models, and over 
100,000 pages of data and results) no later than October 1, 1997. While 
these technical arrangements are being completed, estimated average 
thyroid doses of I-131 in every county of the 48 contiguous states were 
released on August 1 in an ``Interim Final'' form on the NCI's World 
Wide Web site (http://rex.nci.nih.gov; or http://nci.nih.gov) in the 
``What's New'' link.
    The data and mathematical modeling contained in the full report 
were essential to reaching the national average estimated dose. They 
will also serve as tools for public health officials and researchers to 
use to determine exposures and to develop individual dose estimates. In 
fact, it is widely known that fallout from atmospheric weapons tests 
was indeed carried nationwide and that Americans in the contiguous 48 
states at that time experienced some level of exposure. The fallout 
report itself was not intended to provide risk assessments of thyroid 
cancer from iodine-131.
    Unfortunately, a determination of what, if any, health effects 
might result as a consequence of I-131 exposure will require further 
research. Although it has been widely known for many years that 
radionuclides (including I-131) were deposited across the United States 
following atmospheric nuclear bomb tests, what has never been clear is 
the role these varying levels of fallout play in the development of 
cancers, particularly among persons who might have been exposed as 
children. It was hypothesized that if we knew the risk coefficient 
correlating thyroid cancer to I-131 exposure and thyroid doses, and if 
we knew how to estimate how much fallout each individual had been 
exposed to, those population groups who might have been at highest risk 
for developing cancer could be determined. They could then be provided 
with information needed to monitor their health. A preliminary review 
by NCI of regions estimated to have higher overall exposures to I-131 
shows no increased rate of thyroid cancer incidence or mortality in the 
40 years since the Nevada Test Sites began. Further followup is 
underway, and our statistical and registry experts have provided advice 
to state health departments interested in pursuing their own analyses.
    With the passage of Public Law 97-414, NCI was asked to develop 
methodologies to assess the amount of I-131 from fallout to which the 
American people were exposed; to estimate the radiation dose to the 
thyroid from the exposures; and to assess the risk of thyroid cancer 
from this exposure. We have completed two of the three tasks--we have 
successfully developed mathematical models using data and calculations 
from many Federal and private sources. The human I-131 exposure data 
and the few health consequences observed thus far among exposed 
populations studied have not been adequate to calculate thyroid cancer 
risk from these exposures. It had been anticipated that a follow-up 
study of persons living downwind from the Nevada Test Site would 
accomplish this; however, the results of that study, published in 1993, 
were suggestive but not conclusive with respect to thyroid cancer. The 
Chernobyl nuclear accident provides a tragic opportunity to obtain the 
very information needed to make these risk estimates. These data 
together with those from on-going epidemiologic studies in Hanford, 
Washington may be sufficient to provide an estimate of cancer risk that 
can be applied to the estimated doses from I-131 fallout from the 
Nevada Test Site.
    The NCI and the Department of Health and Human Services (DHHS) of 
course recognize that there are potential implications of the I-131 
exposure study for the health of the American people. There was never 
any intention to conceal the results. In fact, the raw data and 
preliminary formulae have been made available upon request during this 
period of preparation and refinement. In addition, the methodologies 
used in the study and preliminary results have been presented at 
scientific meetings and published in the scientific literature since 
1990. Updates to the NCI's Board of Scientific Counselors were frequent 
and open to the public. Periodic progress reports to Congress were 
drafted and forwarded to NIH for transmittal to the Secretary, HHS. The 
Thyroid/Iodine-131 Assessment Committee was chartered in 1984 with 
experts in all the fields of science relevant to this study to advise 
the NCI staff on the conduct of this study. Meetings of the advisory 
committee were open meetings, and it served until 1993 as a place where 
presentations and discussions of the latest findings of the study and 
more broadly in the scientific arena could be aired publicly.
    As I mentioned earlier, the data available to link I-131 fallout to 
specific cancers are not conclusive. All currently available data 
relating to a statistically significant increased risk of thyroid 
cancer are from external irradiation. Therefore, care must be taken to 
craft a public health message to increase awareness of possible health 
effects without creating alarm or undue harm. In the late 1970's, NCI 
undertook a public health campaign to alert people to the possibility 
of developing medical irradiation-related thyroid cancer. The campaign 
was designed to: (1) brief physicians about how to examine, diagnose 
and treat irradiation-related thyroid tumors, and (2) to urge the 
special population in the United States that was at increased risk of 
developing thyroid cancer to be examined by a physician. Because there 
is no established risk coefficient for I-131 and thyroid dose exposure, 
the Department of Health and Human Services has requested that the 
Institute of Medicine (IOM) at the National Academy of Sciences review 
the data to assess whether risks can be determined, and to develop 
recommendations for physicians on how to identify, evaluate, and treat 
persons who might be at risk of thyroid disease because of the 
exposures to radioactive iodine. The IOM estimates that its 
recommendations will be available in June 1998.
    The Department has pledged to pursue the establishment of a task 
force or working group of appropriate Federal agencies to discuss and 
implement the next steps in addressing the public health concerns. In 
the meantime, we are suggesting that concerned individuals consult with 
their physician during their next visit.
    The NCI will be pleased to keep you informed as these matters 
evolve.
            Sincerely,
                                 Richard D. Klausner, M.D.,
                               Director, National Cancer Institute.
                                 ______


                                 
                    Letter From Senator Tom Daschle
                                               U.S. Senate,
                                   Washington, DC, August 27, 1997.
Hon. Donna Shalala,
Secretary, Department of Health and Human Services,
Washington, DC.
    Dear Madam Secretary: Enclosed is a copy of my letter to Dr. 
Klausner reiterating my concerns regarding NCI's handling of its 1982 
congressional mandate to assess the impact of iodine-131 fallout 
associated with open-air nuclear testing between 1951 and 1962. I feel 
strongly that the Institute's inadequate actions in the face of a 
potential threat to the health of thousands of individuals must be 
investigated and explained, both to prevent the situation from 
repeating itself and to demonstrate the government's fundamental 
accountability to the public it serves. Most importantly, NCI must 
fulfill an essential unmet requirement of its mandate: to provide 
insight and guidance on the long and short-term health implications of 
the nuclear testing.
    I am requesting that you work closely with Dr. Klausner and the 
National Cancer Institute to ensure that the public's interests are 
being served from here forward, and to identify and address any 
deficiencies that may account for the Institute's delayed and 
incomplete response to this serious problem.
    Thank you for your attention to this matter. Feel free to contact 
me directly if you have questions.
            Sincerely,
                                               Tom Daschle,
                                                      U.S. Senator.
                                 ______
                                 
                    Letter From Senator Tom Daschle
                                               U.S. Senate,
                                   Washington, DC, August 27, 1997.
Hon. Richard Klausner, M.D.,
Director, National Cancer Institute,
Bethesda, MD.
    Dear Dr. Klausner: As a follow-up to my inquiries over the past 
several months, I would like to reiterate my concerns regarding NCI's 
handling of its congressionally mandated assessment of iodine-131 (I-
131) fallout resulting from the 1950's radiation tests in Nevada. The 
events leading up to and surrounding the release of the National Cancer 
Institute's (NCI) study of I-131 raise serious questions about NCI's 
commitment to its statutory mandate to investigate, on a timely basis, 
the health impact of I-131 fallout.
    As NCI's July 25 press release states, ``In 1982, Congress passed 
legislation calling for the Department of Health and Human Services to 
develop methods to estimate I-131 exposure, to assess I-131 exposure 
levels across the country from the Nevada tests, and to assess risks 
for thyroid cancer from these exposures.'' Fifteen years later, that 
public mandate is still unfilled. Fifteen years later--more than 40 
years after the initial tests--those exposed to the tests have 
virtually no information about the probable impact of the tests on 
their health or the steps they should be taking to protect their 
health. Given NCI's proper emphasis on early detection of cancer and 
other illnesses, this situation is especially troubling.
    I am aware that the estimation process by which NCI calculated 
average radiation dosage required a significant amount of data. 
Nevertheless, that does not account for the lack of any information on 
the progress of the study or any attempt to monitor the incidence of 
thyroid cancer in high exposure areas during the 15-year interim 
period. Neither does it justify NCI's failure, even now, to meet the 
crucial requirement of the 1982 mandate: to access and inform the 
public about the potential health risks associated with the iodine-131 
fallout.
    The stakes are too high to allow this situation to be perpetrated, 
or to repeat itself. A delay in the delivery of crucial health 
information has the potential to manifest itself in very real health 
consequences. In this case, potentially exposed persons have neither 
the direct health information they need nor precautionary health 
guidelines that could serve them in the absence of such direct 
information. Furthermore, inordinate delays such as those that have 
plagued this study have a serious corrosive effect on public confidence 
in the government's commitment to providing them with timely, objective 
scientific information and protecting their health interests.
    I urge you to assess, and report to Congress about, the events 
surrounding the delays associated with this study, take whatever steps 
are necessary to ensure that similar delays do not undermine future NCI 
projects, and establish a date certain for the Institute of Medicine's 
evaluation of the appropriate medical response to the various exposure 
levels associated with the fallout. Finally, I ask that you evaluate 
whether there was a significant change in the incidence of thyroid 
cancer in the wake of the nuclear testing, particularly in ``hot spot'' 
areas. If this information is readily available, I ask that you share 
it with Congress and the public immediately. If it is not yet 
available, please estimate when it will be available and outline what 
precautionary steps should be taken in the meantime by those 
individuals who believe they may have been exposed to potentially 
dangerous levels of radiation. The public deserves a much clearer 
picture of the toll iodine-131 has taken on the Nation's health.
            Sincerely,
                                               Tom Daschle,
                                                      U.S. Senator.

                                ISOTOPE

    Senator Harkin [presiding]. The last couple of questions. 
We are talking here about one isotope. Are there other isotopes 
out there that we have to be concerned about? And if so, what 
are they? What do we know?
    Dr. Klausner. Overwhelmingly, I-131 is the major isotope 
released, but there are other isotopes: strontium-89, 
strontium-90, cesium-137, barium-140, plutonium. And some of 
those in aggregate were addressed by, I think, the important 
Utah leukemia study. These other isotopes are even more 
difficult to assess in terms of exposures, et cetera, 
especially at this time.
    The estimate that I have seen is that the amount of 
radioactivity that individuals were exposed to for any of those 
isotopes were much, much less, significantly less, than I-131. 
That is why the major concern has been about I-131.
    However, we are interested in health effects of these other 
isotopes. There are studies about them. They are very difficult 
studies. They are very controversial results. And we look to 
see whether there are places where we can learn about the 
health and risk estimates from these other studies, such as 
surrounding the Mayac plant at the Techa River in the former 
Soviet Union.
    There are estimates about strontium in particular, about 
its health effects. But as far as we can tell, the total 
exposures from these other radionuclides, as I said, are much, 
much lower to the American people than was I-131. Others here 
may have more expertise about this than I.
    Senator Harkin. Do we know about any other isotopes? 
Cesium, for example, I am told mimics calcium, so it is taken 
up in the bones and could lead to bone cancer. We have had 
increased incidence of bone cancer, we know, in certain areas.
    Dr. Lyon. We did very preliminary studies looking at 
osteogenic sarcomas, which would be assumed to have been--and 
tried to do it on a county by county basis. We found virtually 
no signal coming from it. We abandoned it because it really 
looked to be--the tumors are extraordinarily rare, very, very 
difficult to study. So we backed off on that.
    In our thyroid dose estimations, we took into account other 
forms of iodine, so it becomes radioiodines. There are several 
other, but they are much shorter-lived than iodine-131. 131 has 
a 8-day half-life. These have much shorter half-lives. But they 
were also included in our dose calculations.
    To my knowledge, we have not looked at strontium or cesium 
issues in any great detail.
    Mr. Connor. The only comment I would like to make at this 
time is that historically there was consideration of the total 
number of estimated cancers that would be caused by strontium 
and cesium during the time of the weapons tests, and the 
numbers--the numbers of excess cancer were fairly significant. 
That is one of the reasons that there was strong pressure for 
the test ban treaty.
    So there has been consideration in the past and recognition 
that a number of cancers would be caused, distributed among the 
population. But what was never recognized to the extent was 
this milk pathway. Even though it was known privately, it was 
never brought out publicly that this was a major issue.
    Senator Harkin. Anything else on this specific thing, other 
isotopes? I wanted to follow it up, and especially plutonium 
also. Plutonium is highly carcinogenic and, even though it may 
have been smaller releases, it is much higher and much more 
carcinogenic. And its half-life is 24,000 years. So we still 
have a lot of this stuff floating around.
    I am just wondering, of what concern should that be in 
terms of the amount of plutonium that was released in the 
atmosphere during all these tests?

STATEMENT OF ARJUN MAKHIJANI, COAUTHOR, ARTICLE, 
            ``BULLETIN OF ATOMIC SCIENTISTS''
    Mr. Connor. Senator Harkin, Arjun Makhijani is here today 
and he has done extensive research on isotopes and fallout. If 
you would not mind, could I turn over the mike to him to have 
him provide you with some information on this?
    Senator Harkin. I have a time constraint. That is my 
problem.
    Mr. Connor. We can provide the information for the record.
    Senator Harkin. Bring him up here, yes. I am interested in 
this.
    Just state your name and everything for the record here. 
State your name.
    Mr. Makhijani. My name is Arjun Makhijani, Senator Harkin.
    My colleague Ben Franke actually is the dosimetric expert 
in our shop, but since you called me. He actually compiled 
these numbers in a book we published with the ``International 
Physicians for the Prevention of Nuclear War in 1991.''
    Senator Harkin. Excuse me. Are you not the one that wrote 
the article for the ``Bulletin of Atomic Scientists?''
    Mr. Makhijani. I coauthored it. The principal author is 
back there.
    Senator Harkin. I just wanted to make sure I knew who I was 
talking to here. OK.
    Mr. Makhijani. These numbers are compiled from the United 
Nations Committee, Scientific Committee on the Effects of 
Atomic Radiation, which calculated the doses from atmospheric 
testing and published them. This is the authoritative committee 
on the subject globally.
    And if you take into account the testing from all 
countries--United States, Soviet Union, France, England, and so 
on, China--the cumulative global doses from radioiodine are 
estimated to be about 2 percent of the total doses from all 
radioisotopes released in atmospheric testing. The main 
contributors to dose are--these are integrated dose to the year 
2000 from the beginning of testing--are carbon-14, cesium-137--
in order; well, not quite in order; they are in different order 
in different years. But carbon-14, cesium-137, zirconium-95, 
strontium-90, ruthenium-106, tritium, cerium-144, iodine-131, 
plutonium-239, and then there are a number of others.
    Senator Harkin. All of these are--really, I do not know the 
half-lives and stuff. But do we know any of the health effects 
of all these?
    Mr. Makhijani. Yes, sir; I think quite a lot is known about 
the health effects of many of these isotopes.
    Dr. Beyea. Yes; we do know a great deal about the health 
effects, unfortunately, because of the A-bomb, the bombs that 
were dropped on Hiroshima and Nagasaki, 50 years of followup by 
the radiation health effects research. There is a huge body of 
literature out there that tells us something about the health 
effects of radiation.
    Of course we do not know everything, and that is why we 
need continued study of particularly some of these more obscure 
health effects that have not been as carefully studied.
    Senator Harkin. One last question. Why do you suppose it 
was that the Government of the United States saw fit to inform 
Kodak about fallout and to give them advance warnings on where 
the hot spots would be, but would not do so for the general 
public, especially in Utah and Idaho and places like that?
    I am speculating here. Why would the Government not say: 
Look, we are going to have an atomic bomb blast; for the next 
couple of months, people in this area, you ought not to drink 
milk. Why was that not done? I mean, they told Kodak to protect 
their films.
    Dr. Lyon. I can comment, Senator, on one other 
inconsistency that is even more interesting, and that is that 
the safety standards for the employees of the Federal 
Government working at the test site were substantially 
different than for the general population. The example of that 
was the radiation monitor working in St. George on Shot Harry 
on May 19, 1953, when almost 80 percent of the exposure 
occurred, who spent the whole day out in the stuff, was told 
when he got back that evening, after he put a geiger counter on 
himself and found out he was clicking along at a pretty good 
rate, to burn his clothes, to shower off very thoroughly, by 
his superiors at the Atomic Energy Commission.
    There was not one word said to the citizens that they could 
have done exactly the same thing. I can only assume that there 
was concern about the safety issue shutting down the test site.
    But it would have been a very simple, effective way, and I 
suspect if it had been done we would have found no excess 
leukemia deaths in that county 20 years later.
    Dr. Beyea. Mr. Harkin, I would like to comment on that, 
because over the last few years I have been involved in looking 
at documents, legal cases, discovery in legal cases, and have 
read document after document that suggests to me that there 
really needs to be a very important investigation, historical 
investigation of what happened in this country in terms of 
radiation and radiation research.
    From what I can tell, there basically has been a 
gentleman's agreement for a long, long time to keep from the 
public what is known, to channel research into certain 
circumstances, to make sure that an old boy network is always 
in charge of who is assigning research contracts. I say that as 
speculation. I say that based on limited access to documents.
    But it is a story that some day must be told. How was it 
that so much about radiation was kept from the public for so 
long? And in fact, it actually backfired, because had people 
been open from the very beginning I do not think we would have 
had the same suspicion that we have today, and that is a 
certain irony.
    But I hope that you and other Senators will look into these 
documents that we see in the plutonium injection cases, we see 
in the Oregon prisoners cases, where prisoners were irradiated 
and then had vasectomies. We see this in a number of cases. And 
we read the documents where American officials kept things 
very, very secret and did not pursue scientifically the right 
answers.
    I hope some day you will be able to help us find out the 
total truth.
    Senator Harkin. Well, I think this is the beginning of that 
process.
    Dr. McGuire. Senator, as a mother, I can only imagine what 
my mother-in-law feels like. She is a very educated woman and 
she would never have done anything to hurt her children, and 
she feels like she did it by giving them the cow's milk. So I 
think it certainly would have helped her if she had known.
    Dr. Beyea. Senator, I have just been passed a note that I 
think I should mention. I apparently have slandered the 
American Thyroid Association inappropriately, and it is pointed 
out to me that the American Thyroid Association has recently 
been pushing for stockpiling of potassium iodide in connection 
with reactor accidents. So I do want to mention that everything 
about the association is not bad.
    Senator Harkin. Well, I think I have a lot of other 
questions, but I think the basic answer to them. But out of 
this I hope comes follow up at least--and we will, my staff and 
I am sure the committee staff, will follow up on this to ensure 
that we put together, as I said, NIH, U.S. Public Health, 
Centers for Disease Control and Prevention, to get this 
information out to people. We have got enough information now 
that at least people ought to be aware of it. And I think there 
are certain guidelines that citizens can take right now in 
terms of having checkups.
    Beyond that, I am concerned about studies of other isotopes 
and what may be out there, again in the way of letting people 
know what they ought to do right now.
    I think there is another subset of what we are starting 
here, and that is what was just mentioned by you, Dr. Beyea, 
and that is to try to find out, get some historical research 
here, and find out just what happened and why. Why did it 
happen that way--again, not as a way of self-flagellating 
ourselves as a country, but to sort of set the stage for 
something in the future. In other words, let us make sure we do 
not repeat these kind of things again in the future in this 
country. Enough suspicion and stuff out there of the Federal 
Government. We do not need this kind of thing happening along 
with it.
    I am also concerned, following up, Dr. Lyon, with Senator 
Specter on those grant proposals, and we will definitely follow 
up on that.

                          PREPARED STATEMENTS

    I ask unanimous consent to place in the record the 
statement of the other witnesses who were not able to come 
today, and other statements made by other Senators who were not 
able to be here this morning also.

             Prepared Statement of Senator Dirk Kempthorne

                           RADIATION EXPOSURE

    I would like to thank Chairman Specter for holding this 
important hearing. Today's testimony represents an important 
step forward in our effort to get all of the facts on the 
table.
    The National Institutes of Health (NIH) has released the 
results of a nationwide study of radioactive fallout from 
above-ground nuclear tests conducted during the 1950's in 
Nevada. A large amount of cancer-causing Iodine-131 was 
released into the atmosphere during these tests, raising many 
health concerns.
    Much of the radiation from the tests traveled northward, 
falling over the State of Idaho. In fact, four out of the five 
most exposed counties in the entire country are in Idaho. I 
find it appalling that only now are Idahoans discovering that 
they may have been exposed to dangerous levels of iodine over 
forty years after it occurred. This is simply unacceptable.
    It has been shown that children exposed to radiation can 
develop thyroid cancer later in life. Idahoans exposed to 
radioactive fallout from these nuclear explosions in the 1950's 
may be at risk. If this is the case, the federal government 
must take responsibility for its actions. This responsibility 
includes compensation for victims.
    I have sent letters to Secretaries Shalala and Pena calling 
on the Department of Health and Human Services to work with the 
Department of Energy and the NIH to further investigate this 
troubling disclosure to document all of the health impacts 
resulting from these tests. An aggressive examination 
dedicating all resources necessary is required to get to the 
bottom of this outrage. All options of remediation must be 
examined. At present, I have received a letter from Secretary 
Pena pledging to provide whatever data is necessary. I have 
also received an interim answer from the NIH. The NIH letter 
proposes a plan in which HHS will establish a task force to 
``discuss and implement the next steps in addressing public 
health concerns.''
    I applaud the efforts of the NIH to continue to work to 
provide answers to Americans exposed during these tests. 
Nonetheless, the Federal Government must be more responsive to 
the questions that I and many others have asked about this 
disturbing event.
                                ------                                


                  Prepared Statement of Peter G. Crane

    My name is Peter Crane, and I appreciate the opportunity to 
submit testimony for inclusion in the record of this hearing. 
The Subcommittee deserves the thanks of the American people for 
holding this hearing, and for bringing the attention of the 
public to the health effects of radioactive fallout on the 
thyroid glands of Americans. There can be little doubt that 
lives will be saved, and a great deal of human misery averted, 
because this hearing will have alerted the public and the 
medical community to be watchful for indications of radiation-
caused thyroid illness.
    The purpose of my testimony today is to discuss an issue 
closely related to the health effects of airborne 
radioactivity, and that is the prevention of such illnesses by 
means of the cheap and effective drug potassium iodide--``KI,'' 
in scientific shorthand. In submitting this statement, I am 
acting in my private capacity, as an interested private 
citizen, not in my official capacity as Counsel for Special 
Projects at the United States Nuclear Regulatory Commission.
    My interest in this subject began when I developed thyroid 
cancer, at the age of 26, undoubtedly because of x-ray 
treatments of my tonsils and adenoids when I was two. The 
disease recurred nine years ago, and then it took extensive 
radiation treatment--five hospitalizations over three years--to 
eradicate it. Illnesses of this kind affect not just the 
patient, but the whole family, as my wife could testify. Our 
experience, and that of other thyroid patients whom I know or 
have encountered, makes me believe that radiation-caused 
thyroid disease is worth preventing, if prevention can be 
achieved easily and cheaply--as it can.
    Americans tend to assume that the protection given our 
children is the most complete in the world. Where KI is 
concerned, this is not true. Countries all over the world 
stockpile the drug, in accordance with World Health 
Organization guidance and International Basic Safety Standards 
that the U.S. claims to support. The U.S. does not. And because 
the Government has kept very quiet on the subject of KI, 
comparatively few Americans realize that their children are not 
as well protected against radiation from nuclear accidents as 
children in France, Germany, Slovakia, Sweden, Canada, Japan, 
Switzerland, Poland, and a host of other countries.
    Stockpiling of KI was a major recommendation of the Kemeny 
Commission, which investigated the accident at Three Mile 
Island for President Carter in 1979. The Government promised to 
implement that recommendation but later reneged.
    In 1986, during the Chernobyl disaster, the Poles drew on 
their stockpiles of potassium iodide, gave out 18 million 
doses, and successfully protected their children. Side effects 
were minimal. In the former Soviet Union, however, KI 
stockpiling and distribution were haphazard. We are now seeing 
the tragic consequences: an upsurge of aggressive childhood 
thyroid cancer in children, frequently with spread to the lymph 
nodes, which means extensive surgery. The photographs of the 
young patients show incisions stretching from ear to ear. The 
number of reported cases passed the 1,000 mark sometime in 
1996.
    First and foremost, this is a medical issue, but I am not a 
doctor and do not pretend to be. What do the doctors say about 
potassium iodide? The American Thyroid Association voted 
unanimously last year to urge the Government to stockpile KI 
for nuclear accidents. It has made that recommendation for 
years, and its reasons are compelling. Here is a July 8, 1996, 
letter from Dr. Jacob Robbins, a world-famous thyroid cancer 
specialist with the National Institutes of Health.\1\ 
Describing KI stockpiling as ``long overdue,'' he explained:
---------------------------------------------------------------------------
    \1\ He wrote this letter on behalf of the American Thyroid 
Association, not in his official Government capacity.
---------------------------------------------------------------------------
    ``1. The Chernobyl experience has shown us that thyroid 
cancer is indeed a major result of a large reactor accident, 
even when evacuation is carried out;
    2. The Polish experience has shown us that large scale 
deployment of KI is safe;
    3. The Three Mile Island experience has shown us that it is 
not easy to obtain a good supply of KI in an emergency;
    4. The shelf life of properly packaged KI is extremely 
long;
    5. The advantage of having a supply on hand for immediate 
use far outweighs its moderate cost;
    6. The problems attendant on predistribution are immaterial 
for the matter of creating a stockpile;
    7. No one questions the ability of KI to protect the 
thyroid from radio iodine;
    8. Even though KI administration before any exposure is 
ideal, the Chernobyl experience also has shown us that the 
exposure can continue for days; institution of KI blockade at 
any time in this period is beneficial.''
    As cancers go, thyroid cancer is one of the better ones to 
have--the fatality rate is about five percent in children and 
ten percent in adults. But no cancer is good, and the 1,200 or 
so Americans who die of the disease each year are just as dead 
as those who die of statistically more lethal types of cancer. 
Moreover, even for those who survive the disease, it can have 
major adverse effects on the quality of life.
    You get to see a lot of fallout-caused disease in the 
Marshall Islands, the Central Pacific island group that 
includes Bikini and Eniwetok, where the United States tested 67 
atomic and hydrogen devices in the 1940's and 1950's. I was an 
administrative judge there in 1991 and 1992, serving as a 
member of the Nuclear Claims Tribunal, which administers 
compensation to Marshallese citizens harmed by the bomb tests.
    By far the major health effect of the bombs exploded in the 
Marshalls has been many hundreds of cases of thyroid disease. 
This includes cancer, benign nodules, and hypothyroidism. The 
last of these deserves special mention. Hypothyroidism--
underactivity of the thyroid--can cause irreversible 
retardation in children.\2\ When that happens, the results are 
tragic.
---------------------------------------------------------------------------
    \2\ To combat retardation caused by diet-related hypothyroidism 
(from iodine deficiency), the Kennedy Foundation, headed by Mrs. Eunice 
Kennedy Shriver, has been doing extraordinarily valuable and effective 
work in the Third World to promote iodization of salt. If there is a 
more cost-effective health program anywhere--vast numbers of people 
protected at minimal cost--I am unaware of it.
---------------------------------------------------------------------------
    As for hypothyroidism in adults, a standard medical 
textbook on the thyroid describes it as ``one of the most 
insidious'' of all illnesses. Why? Because it can develop so 
gradually and subtly that no one--not the sufferer, not the 
family--realizes that there is a treatable medical problem.
    In the Marshalls, for example, I was once presenting a 
compensation award to a woman from Eniwetok, and as a courtesy, 
asked her if there was anything she wanted to say. Yes, she 
said, her life was miserable: she was always cold. ``Cold?'' I 
asked, in some astonishment, for the Marshalls are near the 
Equator, and the climate is torrid and steamy all year round. 
``Yes,'' she said, ``even with my electric blanket on high I 
shiver and shake all night long.''
    It took only a few more questions to establish that she had 
all the classic symptoms of hypothyroidism--thyroid 
insufficiency. A Tribunal doctor tested her and prescribed 
synthetic thyroid hormone, and before long she was living a 
normal life. But for her, many years of her life had been 
blighted unnecessarily. There are undoubtedly people very much 
like her in this country too--people who are chronically cold, 
weak, and fatigued, who might be living normal lives if they 
and their families and their doctors knew what to look for.
    If ever there is a major nuclear accident in this country, 
there will probably be many more such people, with illnesses 
that might have been prevented by a dime's worth of medication 
sitting on the shelf of a hospital or fire station.
    The Food and Drug Administration KI ``safe and effective'' 
for use in nuclear accidents some 20 years ago. The drug works 
by saturating the thyroid with iodine in a harmless form, 
thereby ``blocking'' it against the absorption of inhaled or 
ingested radioactive iodine. It has a shelf life of at least 
five years, and costs approximately ten cents for each person 
protected. The NRC's technical staff estimated in 1994 that a 
supply sufficient to protect the combined population around all 
U.S. nuclear plants could be purchased for a total of a few 
hundred thousand dollars--and indeed, that it would be cheaper 
to buy stockpiles of the drug than go on studying whether to do 
so.
    That would seem to be the very definition of a ``no-
brainer.''
    Nevertheless, official U.S. policy still holds that it is 
more ``cost-effective'' to take a chance, and treat the cancers 
if and when they occur, than to spend even that tiny amount on 
prevention.
    The pressing need for stockpiling KI first became apparent 
during the Three Mile Island accident, in 1979. As this 
Subcommittee's Chairman no doubt remembers well, the fate of 
the plant hung in the balance for several nerve-wracking days. 
While reactor operators and Nuclear Regulatory Commission (NRC) 
officials fought to bring the plant under control, federal and 
state officials, fearing a major release that would disperse 
radioactive iodine from the reactor core into the atmosphere, 
searched for supplies of KI and discovered that they did not 
exist. A pharmaceutical company executive, responding to a 
middle-of-the-night plea from the Food and Drug Administration, 
started up the KI production line at 3 o'clock in the morning. 
Supplies of the drug were in Pennsylvania 24 hours later. 
Although the plant experienced a partial core meltdown, the 
accident fortunately was brought under control without the KI 
being needed--that time.
    Afterwards, the President's Commission on the Accident at 
Three Mile Island, headed by John Kemeny, was scathing in 
condemning the Government's failure to keep supplies of the 
drug available. Stockpiling, it said, was long overdue, and it 
recommended prompt corrective action.
    The NRC strongly endorsed that recommendation, and promised 
to make KI a mandatory part of emergency planning for every 
nuclear power plant. The Federal Emergency Management Agency 
(FEMA) made plans to buy national stockpiles of the drug.
    In the fall of 1982, however, FEMA and the NRC technical 
staff, in the space of just a few weeks, reversed themselves--
180 degrees. FEMA dropped KI from its budget, and the NRC 
technical staff hastily withdrew a pro-KI paper that it had 
sent to the NRC Commissioners and replaced it with a paper 
negative on KI. Why? The reasons were not given, but the 
circumstances suggest strongly that politics, and pressure from 
the nuclear industry, won out over health and safety.
    In 1983, at a briefing for the Commissioners and the 
public, senior NRC staff officials explained their new anti-KI 
position. The nuclear accidents in which KI would be useful 
were so rare, they said, and the consequences of a radiation-
caused thyroid ``nodule'' were so slight, that it would be 
cheaper to treat such disease after it occurred than to prevent 
it. One of the briefers was the Commission's Executive Director 
for Operations--the head of the NRC's technical staff--who 
offered the view that the staff's position was ``courageous.''
    The NRC Chairman, Nunzio Palladino, was skeptical of the 
briefers' presentation. He commented that if he survived an 
accident because of twenty cents' worth of KI, he would think 
it ``small change compared to the risk.'' One of the staff 
members quickly corrected him, explaining that ``the surviving 
question is not the question.'' Rather, he said, the issue was 
one of ``averting an illness.'' The briefers made this illness 
sound quite trivial, explaining: ``There's a few days' loss 
from--it's a relatively simple operation that's involved in 
removing the thyroid or removing the nodules.'' Another briefer 
compared KI to an ``amulet,'' and to an insurance policy that 
when read carefully, turns out to offer protection only against 
death by stampeding elephant.
    Given that some 40 percent of radiation-caused nodules are 
cancerous, and that 5 to 10 percent of the cancers are fatal, 
what the briefers were telling the NRC Chairman--their boss--
was poppycock. Only much later was it explained that in 
referring to ``nodules,'' they meant benign nodules only.
    This was as though you offered a public briefing on the 
value of seat belts in car accidents without mentioning that 
you were defining ``accidents'' as collisions occurring at 
under 5 miles per hour. For compared to cancer, a benign 
thyroid nodule is a fender-bender. And the briefers never 
discussed cancer at all.
    The NRC staff was successful in winning over the 
Commissioners, and the ultimate result was a 1985 Federal 
policy statement, still in place today, declaring it ``not 
worthwhile'' to require KI stockpiling. Thus the recommendation 
of the Kemeny Commission was quietly disposed of, at a time 
when memories of Three Mile Island had faded--except, perhaps, 
in Pennsylvania--and thoughts of nuclear accidents were far 
from most people's minds.
    It did not take long, however, for the Government's folly 
and irresponsibility to be revealed. In April 1986, just 9 
months after the policy statement was issued; the Chernobyl 
accident sent a cloud of radioactive iodine and other fallout 
across Europe. Inhaled and also ingested, through milk and 
vegetables, the radioactive iodine lodged in the thyroids of 
children and adults. In 1991, doctors in the vicinity of Minsk, 
in Belarus, began to see a pattern of increasing numbers of 
cases of childhood thyroid cancer.
    The medical crisis in the former Soviet Union is far from 
over. The number of childhood cancers continues to rise, and in 
addition, the latency period for adult thyroid cancer is longer 
than for children, so we can expect to see new thyroid cancers 
appearing in the Chernobyl-affected areas even 30 or more years 
from now.
    Why did Chernobyl and the cancers resulting from it not 
turn U.S. policy around? In an ideal world, they would have: 
The Federal Government would immediately have acknowledged that 
the President's Commission on Three Mile Island had been right 
all along about KI, and would promptly have made stockpiling a 
reality. But that didn't happen, perhaps because an admission 
of error might have raised awkward questions about why the 
recommendations of the President's Commission had been ignored 
in the first place. So the Government hunkered down, saying and 
doing nothing that would have raised public awareness of the KI 
issue. It is hard to escape the conclusion that protecting 
bureaucrats from embarrassment took priority over protecting 
children from cancer.
    In the years since Chernobyl, stockpiling of KI has become 
routine in countries around the world. In April 1996, there was 
an international conference in Vienna on the health effects of 
the disaster. An American radiologist described the epidemic of 
childhood thyroid cancer as a ``completely preventable 
problem,'' and said that the use of KI ``ought to be No. 1 on 
the list'' of the lessons of Chernobyl. He lamented that his 
own country continued to lag behind in protecting its people.
    The Government's silence ensures that most Americans are in 
the dark. Just last year, on the 10th anniversary of Chernobyl, 
a Congressional resolution called on the President to make sure 
that the health lessons learned from Chernobyl were made 
available to nations around the world. Congress clearly assumed 
that the U.S. was in the lead in applying the lessons of 
Chernobyl; I suspect that those who voted for the resolution 
would be quite surprised to discover that we are actually at 
the back of the pack. They might well ask why, if the Poles can 
afford to keep 90 million doses of KI on the shelf, we can't 
manage to do as well by our children.
    Is this a disease so trivial that it is not worth 
preventing? Ask some patients. They will tell you that thyroid 
cancer can have major effects on the quality of life. First, 
patients must take synthetic thyroid hormone daily for the rest 
of their lives, which for many is a serious economic burden. In 
preparation for diagnostic procedures and radiation treatments, 
moreover, they must switch for several weeks to a different 
thyroid hormone, with different physiological and psychological 
effects. Then they must stop taking medication altogether, 
which results in hypothyroidism. In this state, the patient--
like the Marshallese woman I described--is weak, chronically 
fatigued, and abnormally sensitive to cold, often shivering 
uncontrollably in temperatures that others in the same room 
find comfortable. After treatment, the patient needs to be 
reintroduced to medication, which for many is a difficult 
process, because there is great variation from one person to 
the next in the amount of hormone that the body needs.
    The result of these various changes often is a physical and 
emotional roller-coaster lasting weeks or months. Does anyone 
remember when President George Bush could not speak in public 
without dissolving in tears? It was just the ups-and-downs of a 
thyroid patient, getting back on medication after a radiation 
treatment.\3\ Some people never succeed in making the 
adjustment. The widow of a member of this body, the late 
Senator John East of North Carolina, was quoted as saying that 
it was his doctors' inability to get his thyroid medication in 
proper balance that drove him to take his own life.
---------------------------------------------------------------------------
    \3\ President Bush, and Mrs. Bush as well, had Graves' disease, in 
which the thyroid is overactive. It is an indication of how subtle and 
hard to detect thyroid problems can be that the President's extreme 
hyperthyroidism was not even noticed until it caused him to collapse 
and be hospitalized.
---------------------------------------------------------------------------
    Thyroid cancer, in sum, though it is usually curable--
emphasis on ``usually''--and though there are many much worse 
illnesses, nevertheless can be extremely disagreeable. It is 
also frightening to have any cancer. (If there are people who 
do not find it frightening, they are braver than I am, or 
dumber.) Is it worth preventing, if we can do so cheaply? Of 
course it is.
    Twice in recent years the Government has come close to 
rectifying its long failure to ensure KI stockpiling. In 1994, 
responding to a ``differing professional opinion'' that I had 
filed 5 years earlier, the NRC staff at last acknowledged that 
KI stockpiling was a ``prudent'' measure, and recommended a 
change in Federal policy. The NRC staff estimated that a few 
hundred thousand dollars would buy a stockpile of the drug 
sufficient for the entire country.
    Senators Joseph Lieberman and Alan Simpson--an Eastern 
Democrat and a Western Republican--weighed in on the issue, 
writing a letter to the NRC that made compelling arguments for 
stockpiling KI. (A copy is attached to this statement.) The 
Senators pointedly reminded the Commissioners of the 
Government's ``moral responsibility to provide the public with 
complete and accurate information regarding the risks from 
federally licensed activities and ways in which those risks may 
be reduced.''
    But their bipartisan advice was not taken. The NRC 
Commissioners divided 2 to 2, and under NRC rules, a tie vote 
on a staff proposal means the proposition fails. The old policy 
stayed in place, and the public remained no wiser than before.
    This year the issue was back before the NRC. On June 30, 
the Commissioners voted 3-2 in favor of a proposal under which 
the Federal Government would fund the cost of KI pills for any 
state requesting them. The two dissenters, who thought the 
majority had not gone far enough, were the Commission's newest 
members, Nils J. Diaz, a Republican, and Edward McGaffigan, 
Jr., a Democrat. They voted to make KI stockpiling a mandatory 
part of NRC emergency planning regulations.
    The Commission majority's approach sounds better than it 
is. Most states, having been assured by the Federal Government 
for 15 years that KI is undesirable, do not realize that it 
could be useful. So far, the NRC has not yet been willing to 
say out loud that stockpiling KI is a prudent and sensible 
measure, and to recommend in so many words that states avail 
themselves of the free KI. Will states and the public 
understand what the stakes are, when the July 1 NRC press 
release announcing the majority's decision did not even mention 
the word ``cancer?'' This was comparable to announcing the 
availability of ``Sabin vaccine'' without mentioning that its 
purpose is to prevent polio.
    Moreover, the majority's approach relies on the fact that 
the Government plans to establish caches of medicines and 
supplies in 27 cities as a defense against terrorism. KI will 
be among those medicines. But with no indication as to the 
amounts of stockpiled KI, or their locations, it is not 
realistic to expect that these stockpiles will be useful for 
nuclear power plant accidents, when there has been no planning 
at the state and local level to use the drug.\4\
---------------------------------------------------------------------------
    \4\ In fairness to the Commission, I should note that it 
specifically reserved judgment on whether to grant a petition for 
rulemaking, filed by me, that would have amended NRC's emergency 
planning rules to require facility emergency plans to make provision 
for evacuation, sheltering, and KI. Thus the Commission has not yet 
completed action on the KI issue, and it should not be assumed that it 
is close-minded on the subject.
---------------------------------------------------------------------------
    In Canada, nuclear utilities support stockpiling of KI in 
part because they consider it good public relations to show 
that they leave no stone unturned in protecting the public. The 
U.S. nuclear industry, on the other hand, has fought 
stockpiling adamantly, in part because--as it openly admits--it 
thinks that KI will make the public more apprehensive about 
nuclear power.
    The vacuum of leadership from the Federal Government on the 
KI issue has led some states to explore the question for 
themselves. Last winter, the Maine Advisory Commission on 
Radiation voted unanimously to recommend stockpiling of KI in 
evacuation centers near the state's only nuclear plant, and the 
Governor accepted that recommendation. Maine joins Tennessee 
and Alabama, which have long maintained supplies of the drug. 
New York and now Ohio have begun looking into the issue.
    All too many states, however, remain steadfast in their 
opposition to KI--an opposition often grounded in ignorance of 
basic facts. For example, in 1996, at a meeting at the Federal 
Emergency Management Agency on the subject, a representative of 
the Illinois Department of Nuclear Safety justified his 
opposition to KI by declaring, ``Loss of the thyroid is not 
life-threatening.'' \5\
---------------------------------------------------------------------------
    \5\ Curiously, the identical language appeared in the statement 
submitted separately by a representative of the state of South 
Carolina.
---------------------------------------------------------------------------
    The quoted statement is true only in the same limited sense 
in which it is true that loss of a breast is not life-
threatening. For the cancer that causes you to lose your 
thyroid, or your breast, can kill you. If the officials of 
Illinois and South Carolina still do not know that, it is a 
reflection of how badly the federal agencies have failed in 
their duty of giving states accurate and complete information.
    Can taking KI during an accident prevent all the health 
effects I have described? Yes, if you can get it to people in 
time. But can you get it to people in time? That may depend on 
the circumstances of the event. There is no guarantee you will 
get it to everyone. But if there are no KI stockpiles, then it 
is guaranteed that you won't get it to anyone.
    The question that readers may be asking by now is this: If 
the case for KI is as compelling as I have suggested, what are 
the arguments against it? The arguments one hears against KI 
fall into two classes. First, there are those that are just 
plain invalid--factually incorrect. The second are the 
objections that although they may be factually correct--for 
example, that evacuation is generally the best option--are 
still not a good reason to be without KI stockpiles.
    I will start with the invalid arguments, which number six.
    1. There is no new data challenging existing policy.--In 
fact, there is a wealth of new data since Chernobyl, such as 
the presentations at the April 1996 conference mentioned 
earlier, suggesting that airborne radiolodines are more 
dangerous to children's thyroids than previously suspected. But 
even if there were no new data, the existing policy was 
defective from the start, because it was based on 
misinformation.
    2. Loss of the thyroid is not life-threatening.--A March 
1996 publication of the nuclear industry's own lobbying group, 
the Nuclear Energy Institute, reported 550 cases of childhood 
thyroid cancer in the former Soviet Union, with five 
fatalities. (The numbers are higher now.) If it's life-
threatening in Minsk, it's life-threatening in Mason City and 
Middletown. In any case, who says a disease has to be life-
threatening to be worth preventing? That's not the standard we 
use when we have our kids immunized against mumps, measles, and 
chicken pox.
    3. KI is not cost-effective.--KI is an insurance policy--
backup protection in case of certain events that are unlikely 
but have serious consequences when they do occur. Is it ``cost-
effective?'' The problem with framing the issue that way is 
that if by ``cost-effective'' you mean ``likely to pay for 
itself over time,'' no insurance policy meets that test. The 
insurance companies would all be bankrupt if they didn't take 
in more from the average buyer than they pay out. Rational 
people, when deciding whether insurance is worthwhile, don't 
ask whether it is sure to pay for itself, but whether it 
provides valuable protection at a reasonable cost. Stockpiling 
of KI meets that test.
    4. KI could complicate evacuation.--You sometimes hear the 
argument that KI will diminish safety in an emergency, because 
people will ignore evacuation orders and go looking for KI 
instead. That's very farfetched. In fact, if you wanted to 
encourage evacuation, you might want to tell people over radio 
and television that when they get to the evacuation center, 
they will be checked out medically and given a medicine, 
potassium iodide, that will help protect them against 
radiation. And you add that this drug will not be available 
locally. So KI should not be a hindrance to an orderly 
evacuation; it might even be an incentive.
    5. KI carries a risk of serious side effects.--The best 
data on side effects comes from the Polish experience after 
Chernobyl, which is documented in a medical journal article co-
written by a Polish health official and an NIH scientist. The 
Poles gave out 18 million doses. Two people were hospitalized, 
briefly. Both of them had known iodine allergies and took the 
drug in spite of being warned not to. Our own FDA says the 
benefit outweighs the side effects. The doctors of the American 
Thyroid Association were well aware of the side effects issue 
when they unanimously endorsed stockpiling in November 1996.
    6. KI could increase state's risk of liability.--
Distribution of KI would take place only after an advisory from 
the federal government that it was appropriate. In that 
situation, with a state following federal directives and doing 
the best it could under emergency conditions, who would find a 
state liable? If I were a state, I would be much more worried 
about the consequences of not having a KI stockpile, given all 
that is known about the drug's value. If ever there were an 
accident, and it turned out a state had no KI to give out 
because it had taken its medical advice from lobbyists instead 
of doctors, that would be the time to worry about liability.
    The following are six arguments I consider factually 
accurate, but still not persuasive reasons to forgo 
stockpiling.
    7. Evacuation is preferable.--The most common argument 
against KI is also the most meritless: that evacuation is 
better, so we don't need KI and shouldn't even have it around 
as a precaution. The problem is that evacuation isn't always 
feasible. The NRC and FEMA have never claimed it was. KI is 
backup protection--Plan B--for those situations where 
evacuation cannot be completed in time to avoid a substantial 
radiation dose to the thyroid--for example, because of adverse 
weather conditions, blocked roads, or widely dispersed 
radioactivity. Also, people may be exposed to radiation while 
they are evacuating--automobiles don't afford much protection.
    Moreover, it is not an either/or proposition. You don't 
choose between backing evacuation and backing stockpiling of 
KI; you do both. The question is whether you have three weapons 
in your arsenal--evacuation, sheltering, and KI--or only two, 
in a situation when the third weapon costs only a pittance.
    The lifejackets on a ferryboat are a pretty close parallel 
to KI. Are ferryboat disasters common? No. Is the lifejacket 
the best way of escaping harm if a ferry sinks? No, you're 
better off being evacuated by lifeboat or helicopter--if that 
is possible. But does that mean we should dispense with 
lifejackets? Of course not. We have lifejackets because in the 
rare instance in which you need them, you are in grave danger 
without them. So we have lifeboats and lifejackets, because 
it's the sensible and prudent thing to do.
    8. Big accidents are unlikely.--It is true that big 
accidents are unlikely. Generally speaking, a combination of 
good design, good operation, and good regulation makes American 
nuclear reactors quite safe. But there is a big difference 
between saying that accidents are unlikely and saying that they 
cannot happen. If we could be sure that accidents would not 
happen, then all emergency planning--sirens, drills, and the 
like--could go out the window. The cost of KI is a drop in the 
bucket by comparison to what is already spent on emergency 
preparedness. The reason we have sirens and drills and the rest 
is that we know that accidents can happen. (So can acts of 
terrorism.) If we accept the idea that emergency preparedness 
makes sense, then our preparedness ought to be first-rate, not 
second-rate.
    9. Public confidence in the technology could be affected.--
That is a quotation from an industry ``White Paper'' on KI that 
was sent to the Nuclear Regulatory Commission in 1993. The same 
argument could be made to assert that we shouldn't have 
containments or emergency core cooling systems at nuclear 
plants, since both of those structures might remind people that 
accidents can happen.
    You don't hear the ferryboat operators complaining that 
having lifejackets on board will diminish confidence in 
ferryboat technology. If I were the industry, I would be 
embracing KI, and making the point that even though it is very 
unlikely that it would ever be needed, the industry is 
committed to ensuring that Americans are protected to the 
highest standard in the world.
    10. The logistics of distribution need more study.--The 
opponents of KI stockpiling sometimes try to change the subject 
from whether KI is a valuable protective measure (an argument 
they know they will lose) to the logistics of delivering the 
drug in an emergency. The idea is to make the delivery of KI 
sound just impossibly complicated, so as to put off, preferably 
forever, the question of whether it makes sense to have the 
drug at all. Those arguments were made at the June 1996 meeting 
at FEMA, and answered by Dr. Jacob Robbins of the National 
Institutes of Health, whom I quoted earlier. He observed that 
there were two issues: whether to stockpile KI, and how to 
deliver it to people in an emergency. He said:
    ``You're sort of asking the question: Which should come 
first? If you remember back to the Three Mile Island incident, 
there was no stockpile. It was requested. With a great deal of 
difficulty, in a rather inadequate way, it was finally made 
available. And it was ready to be used but with a delay. I 
think we have to think of both aspects. And what the American 
Thyroid Association has said is create the stockpiles, have 
them available, and then have expert groups developing the 
mechanisms of how to distribute this in time of need.''
    It's hard to quarrel with that advice: make the decision in 
principle that having KI makes sense, establish stockpiles, and 
then work out the logistics of how you want to distribute it. 
While you are thinking about logistics, the drug can be onsite 
in schools, or hospitals, or fire stations, or all three.
    11. The states don't want it.--This is an argument you hear 
again and again at the federal level. The Federal Government 
has been giving the states inaccurate and incomplete 
information about KI for 15 years, and it is small wonder that 
many of them believe that KI is undesirable. Once states begin 
to get full and up-to-date information about KI, their attitude 
toward stockpiling is likely to change, as Maine's did.
    12. People can buy it for themselves.--The argument can be 
made that people are free to buy the drug for themselves, and 
that the states and the Federal Government should not be 
involved. First, the drug is unlikely to be available locally. 
Second, people will know to buy the drug only if the 
authorities accept the obligation of informing them. It would 
probably be cheaper to buy a stockpile than to take on the task 
of telling people that they should consider buying it. Third, 
in an emergency, some people--such as schoolchildren--will not 
be at home. Fourth, do you really want to say that for the 
people who didn't have the foresight or money to buy the drug, 
it's their tough luck?
    To leave it up to individuals would be like telling 
ferryboat passengers that they are free to bring their own 
lifejackets. It's simpler, fairer, and better health policy to 
stockpile KI and bring it out for the entire affected 
population in time of need.
    In conclusion, Americans have a right, where nuclear 
hazards are involved, to expect their Government to ensure that 
they are protected adequately and that they are given accurate 
and complete information. In the case of potassium iodide, the 
Government has so far done neither. It is high time that the 
Federal Government lived up to its responsibilities, so that we 
can at last say that American children enjoy radiation 
protection second to none.
    Thank you.
    Attachment:
                                ------                                

      Letter from Senators Joseph I. Lieberman and Alan K. Simpson
                                       U.S. Senate,
                 Committee on Environment and Public Works,
                                    Washington, DC, April 20, 1994.
Hon. Ivan Selin,
Chairman, U.S. Nuclear Regulatory Commission,
Washington, DC.
    Dear Chairman Selin: We are writing to urge the Nuclear Regulatory 
Commission (NRC) to revise its current policy regarding the 
availability and use of potassium iodide (KI) in the event of an 
emergency at a nuclear power plant.
    The NRC's current policy is that state and local governments should 
consider stockpiling KI for emergency use by emergency workers and 
institutionalized persons, but not for the general public. This policy 
was established in the early 1980's. Since that time, however, new 
information has arisen and additional experience has been gained on the 
costs and benefits of the prophylactic use of KI by the general 
population. We believe that this new information and experience 
requires a new approach to this issue.
    It is well established scientifically that KI is extremely 
effective in preventing the uptake of radioactive iodine by the 
thyroid. If taken in the proper dose prior to exposure to radioactive 
iodine KI can completely block the uptake of the radioactive iodine.
    The distribution of KI to the general population in the event of 
nuclear emergency is a widely accepted protective measure. The World 
Health Organization has recommended its use for people living near a 
nuclear power plant if radiation levels are expected to exceed a 
predetermined dose. A number of foreign governments-- including the 
United Kingdom, the Czech Republic, Switzerland, Canadian provinces 
with nuclear power plants, and the former Soviet Union--stockpile KI 
for distribution to and use by the general public in the event of a 
nuclear emergency. In the United States, three States--Alabama, 
Tennessee, and Arizona--have plans to distribute or already have 
distributed KI to people living near one or more nuclear power plants 
within those States.
    A recent cost-benefit study of this issue conducted for NRC 
indicates that the costs of stockpiling KI for people who live within 
five miles of a nuclear power plant are minimal--approximately 10 cents 
per person per year. This means that for a typical population of 10,000 
people living within five miles of a nuclear power plant, it would cost 
approximately $1,000 to make KI available for distribution. The NRC 
staff projects that the cost of stockpiling KI for everyone in the 
country within five miles of a nuclear power plant would be on the 
order of several hundred thousand dollars per year. This is only a 
small fraction of the expenses already spent on emergency planning. As 
the NRC staff has noted, ``[c]osts in this range present no significant 
barrier to stockpiling and are probably less than the cost of the 
continued studies.''
    Some concern has been expressed that public education on the use of 
KI may result in a potentially significant negative public perception. 
However, no evidence has been provided that any of the existing 
policies in other nations or in the States that provide for the use of 
KI by the general population has caused any undue panic or apprehension 
to the general public. Moreover, the Federal Government has a moral 
responsibility to provide the public with complete and accurate 
information regarding the risks from federally-licensed activities and 
ways in which those risks may be reduced.
    In sum, therefore, KI can be an extremely effective countermeasure 
to prevent damage to the thyroid in the event of a radiological 
emergency. It can also be made available for the general population 
living near a nuclear power plant for minimal costs. The NRC should 
revise its policy to provide this additional potential protective 
measure for nuclear emergency planning.
    We thank you for your time and consideration.
            Sincerely,
                                   Alan K. Simpson,
                                           Ranking minority member, 
                                               Subcommittee on Clean 
                                               Air and Nuclear 
                                               Regulation.
                                   Joseph I. Lieberman,
                                           Chairman, Subcommittee on 
                                               Clean Air and Nuclear 
                                               Regulation.

                         CONCLUSION OF HEARING

    Senator Harkin. Anything else before we close the meeting 
down? Dr. Klausner, any final last observations or requests, 
advice, to this committee?
    [No response.]
    Senator Harkin. If not, we thank you all very much for your 
time and for your information, that concludes our hearing. The 
subcommittee will stand in recess subject to the call of the 
Chair.
    [Whereupon, at 10:40 a.m., Wednesday, October 1, the 
hearing was concluded, and the subcommittee was recessed, to 
reconvene subject to the call of the Chair.]

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