[Congressional Bills 109th Congress]
[From the U.S. Government Publishing Office]
[S. 757 Reported in Senate (RS)]







                                                       Calendar No. 530
109th CONGRESS
  2d Session
                                 S. 757

                          [Report No. 109-290]

To amend the Public Health Service Act to authorize the Director of the 
National Institute of Environmental Health Sciences to make grants for 
      the development and operation of research centers regarding 
  environmental factors that may be related to the etiology of breast 
                                cancer.


_______________________________________________________________________


                   IN THE SENATE OF THE UNITED STATES

                             April 11, 2005

Mr. Chafee (for himself, Mr. Reid, Mr. Talent, Mrs. Clinton, Mr. Hatch, 
 Ms. Cantwell, Mr. Allen, Ms. Collins, Mr. Grassley, Mr. Corzine, Mr. 
   Harkin, Mrs. Murray, Mr. Bingaman, Mr. Kennedy, Mr. Cochran, Mr. 
DeWine, Mr. Warner, Mr. Coleman, Mr. Lautenberg, Mr. Dayton, Mr. Biden, 
Mr. Voinovich, Mr. Johnson, Mr. McCain, Mrs. Feinstein, Mr. Smith, Ms. 
  Mikulski, Mr. Reed, Mr. Feingold, Mr. Sarbanes, Mr. Lieberman, Mr. 
   Kohl, Mr. Schumer, Mr. Sununu, Mrs. Hutchison, Ms. Murkowski, Ms. 
    Stabenow, Mr. Carper, Mr. Specter, Mr. Kerry, Mr. Jeffords, Ms. 
Landrieu, Mr. Dodd, Mrs. Lincoln, Mrs. Boxer, Mr. Bayh, Mr. Dorgan, Mr. 
 Pryor, Mr. Hagel, Mr. Bennett, Mr. Conrad, Ms. Snowe, Mr. Leahy, Mr. 
 Vitter, Mr. Salazar, Mr. Wyden, Mr. Lugar, Mr. Graham, Mr. Domenici, 
  Mr. Cornyn, Mr. Baucus, Mrs. Dole, Mr. Menendez, Mr. Santorum, Mr. 
  Burns, Mr. Kyl, and Mr. Nelson of Florida) introduced the following 
  bill; which was read twice and referred to the Committee on Health, 
                     Education, Labor, and Pensions

                             July 24, 2006

                Reported by Mr. Enzi, with an amendment
 [Strike out all after the enacting clause and insert the part printed 
                               in italic]

_______________________________________________________________________

                                 A BILL


 
To amend the Public Health Service Act to authorize the Director of the 
National Institute of Environmental Health Sciences to make grants for 
      the development and operation of research centers regarding 
  environmental factors that may be related to the etiology of breast 
                                cancer.

    Be it enacted by the Senate and House of Representatives of the 
United States of America in Congress assembled,

<DELETED>SECTION 1. SHORT TITLE.</DELETED>

<DELETED>    This Act may be cited as the ``Breast Cancer and 
Environmental Research Act of 2005''.</DELETED>

<DELETED>SEC. 2. FINDINGS.</DELETED>

<DELETED>    The Congress finds as follows:</DELETED>
        <DELETED>    (1) Breast cancer is the second leading cause of 
        cancer deaths among American women.</DELETED>
        <DELETED>    (2) More women in the United States are living 
        with breast cancer than any other cancer (excluding skin 
        cancer). Approximately 3,000,000 women in the United States are 
        living with breast cancer, about 2,000,000 of which have been 
        diagnosed and an estimated 1,000,000 who do not yet know that 
        they have the disease.</DELETED>
        <DELETED>    (3) Breast cancer is the most commonly diagnosed 
        cancer among women in the United States and worldwide 
        (excluding skin cancer). In 2005, it is estimated that 269,730 
        new cases of breast cancer will be diagnosed among women in the 
        United States, 211,240 invasive breast cancers and 58,490 cases 
        of ductal carcinoma in situ (DCIS).</DELETED>
        <DELETED>    (4) Approximately 40,410 women in the United 
        States will die from the disease in 2005. Breast cancer is the 
        leading cause of cancer death for women in the United States 
        between the ages of 20 and 59, and the leading cause of cancer 
        death for women worldwide.</DELETED>
        <DELETED>    (5) A woman who lives into her 80s in the United 
        States has a 1 in 7 chance of developing invasive breast cancer 
        in her lifetime. This risk was 1 in 11 in 1975. In 2005, a new 
        case of breast cancer will be diagnosed every 2 minutes and a 
        woman will die from breast cancer every 13 minutes.</DELETED>
        <DELETED>    (6) All women are at risk for breast cancer. About 
        90 percent of women who develop breast cancer do not have a 
        family history of the disease.</DELETED>
        <DELETED>    (7) The National Action Plan on Breast Cancer, a 
        public private partnership, has recognized the importance of 
        expanding the scope and breadth of biomedical, epidemiological, 
        and behavioral research activities related to the etiology of 
        breast cancer and the role of the environment.</DELETED>
        <DELETED>    (8) To date, there has been only a limited 
        research investment to expand the scope or coordinate efforts 
        across disciplines or work with the community to study the role 
        of the environment in the development of breast 
        cancer.</DELETED>
        <DELETED>    (9) In 2003, the National Institute of 
        Environmental Health Sciences awarded grants to four research 
        centers to begin to study the prenatal-to-adult environmental 
        exposures that may predispose a woman to breast cancer. The 
        currently funded research is examining the mammary tissue in 
        animals and young girls and study the subjects' life exposures 
        to environmental, nutritional, and social factors that impact 
        menarche. Early menarche, beginning menstruation before the age 
        of 12, has been shown to increase breast cancer risk later in 
        life.</DELETED>
        <DELETED>    (10) The National Cancer Institute and the 
        National Institute of Environmental Health Sciences have paired 
        together to make those four centers possible. The two 
        institutes work well together, combining their respective areas 
        of expertise to the best advantage of the research.</DELETED>
        <DELETED>    (11) In order to take full advantage of the 
        tremendous potential for avenues of prevention, the Federal 
        investment in the role of the environment and the development 
        of breast cancer should be expanded. The research conducted at 
        the four centers, while critically important, is one small 
        facet of the many issues that must be addressed in order to 
        gauge the link between environmental factors and breast 
        cancer.</DELETED>
        <DELETED>    (12) In order to understand the effect of 
        chemicals and radiation on the development of cancer, multi-
        generational, prospective studies are probably 
        required.</DELETED>

<DELETED>SEC. 3. NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; 
              AWARDS FOR DEVELOPMENT AND OPERATION OF RESEARCH CENTERS 
              REGARDING ENVIRONMENTAL FACTORS RELATED TO BREAST 
              CANCER.</DELETED>

<DELETED>    Subpart 12 of part C of title IV of the Public Health 
Service Act (42 U.S.C. 285 l et seq.) is amended by adding at the end 
the following section:</DELETED>

<DELETED>``SEC. 463C. RESEARCH CENTERS REGARDING ENVIRONMENTAL FACTORS 
              RELATED TO BREAST CANCER.</DELETED>

<DELETED>    ``(a) In General.--The Director of the Institute, based on 
recommendations from the Breast Cancer and Environmental Research Panel 
established under subsection (b) (referred to in this section as the 
`Panel') shall make grants, after a process of peer review and 
programmatic review, to public or nonprofit private entities for the 
development and operation of not more than 8 centers for the purpose of 
conducting multidisciplinary and multi-institutional research on 
environmental factors that may be related to the etiology of breast 
cancer. Each such center shall be known as a Breast Cancer and 
Environmental Research Center of Excellence.</DELETED>
<DELETED>    ``(b) Breast Cancer and Environmental Research Panel.--
</DELETED>
        <DELETED>    ``(1) Establishment.--The Secretary shall 
        establish in the Institute of Environmental Health Sciences a 
        Breast Cancer and Environmental Research Panel.</DELETED>
        <DELETED>    ``(2) Composition.--The Panel shall be composed 
        of--</DELETED>
                <DELETED>    ``(A) 9 members to be appointed by the 
                Secretary, of which--</DELETED>
                        <DELETED>    ``(i) six members shall be 
                        appointed from among physicians, and other 
                        health professionals, who--</DELETED>
                                <DELETED>    ``(I) are not officers or 
                                employees of the United 
                                States;</DELETED>
                                <DELETED>    ``(II) represent multiple 
                                disciplines, including clinical, basic, 
                                and public health sciences;</DELETED>
                                <DELETED>    ``(III) represent 
                                different geographical regions of the 
                                United States;</DELETED>
                                <DELETED>    ``(IV) are from practice 
                                settings or academia or other research 
                                settings; and</DELETED>
                                <DELETED>    ``(V) are experienced in 
                                biomedical review; and</DELETED>
                        <DELETED>    ``(ii) three members shall be 
                        appointed from the general public who are 
                        representatives of individuals who have had 
                        breast cancer and who represent a constituency; 
                        and</DELETED>
                <DELETED>    ``(B) such nonvoting, ex officio members 
                as the Secretary determines to be 
                appropriate.</DELETED>
        <DELETED>    ``(3) Chairperson.--The members of the Panel 
        appointed under paragraph (2)(A) shall select a chairperson 
        from among such members.</DELETED>
        <DELETED>    ``(4) Meetings.--The Panel shall meet at the call 
        of the chairperson or upon the request of the Director, but in 
        no case less often than once each year.</DELETED>
        <DELETED>    ``(5) Duties.--The Panel shall--</DELETED>
                <DELETED>    ``(A) oversee the peer review process for 
                the awarding of grants under subsection (a) and conduct 
                the programmatic review under such 
                subsection;</DELETED>
                <DELETED>    ``(B) make recommendations with respect to 
                the funding criteria and mechanisms under which amounts 
                will be allocated under this section; and</DELETED>
                <DELETED>    ``(C) make final programmatic 
                recommendations with respect to grants under this 
                section.</DELETED>
<DELETED>    ``(c) Collaboration With Community.--Each center under 
subsection (a) shall establish and maintain ongoing collaborations with 
community organizations in the geographic area served by the center, 
including those that represent women with breast cancer.</DELETED>
<DELETED>    ``(d) Coordination of Centers; Reports.--The Director of 
the Institute shall, as appropriate, provide for the coordination of 
information among centers under subsection (a) and ensure regular 
communication between such centers, and may require the periodic 
preparation of reports on the activities of the centers and the 
submission of the reports to the Director.</DELETED>
<DELETED>    ``(e) Required Consortium.--Each center under subsection 
(a) shall be formed from a consortium of cooperating institutions, 
meeting such requirements as may be prescribed by the Director of the 
Institute. Each center shall require collaboration among highly 
accomplished scientists, other health professionals and advocates of 
diverse backgrounds from various areas of expertise.</DELETED>
<DELETED>    ``(f) Duration of Support.--Support of a center under 
subsection (a) may be for a period not exceeding 5 years. Such period 
may be extended for one or more additional periods not exceeding 5 
years if the operations of such center have been reviewed by an 
appropriate technical and scientific peer review group established by 
the Director of the Institute and if such group has recommended to the 
Director that such period should be extended.</DELETED>
<DELETED>    ``(g) Geographic Distribution of Centers.--The Director of 
the Institute shall, to the extent practicable, provide for an 
equitable geographical distribution of centers under this 
section.</DELETED>
<DELETED>    ``(h) Innovative Approaches.--Each center under subsection 
(a) shall use innovative approaches to study unexplored or under-
explored areas of the environment and breast cancer.</DELETED>
<DELETED>    ``(i) Authorization of Appropriations.--For the purpose of 
carrying out this section, there is authorized to be appropriated 
$30,000,000 for each of the fiscal years 2006 through 2011. Such 
authorization is in addition to any other authorization of 
appropriations that is available for such purpose.''.</DELETED>

SECTION 1. SHORT TITLE.

    This Act may be cited as the ``Breast Cancer and Environmental 
Research Act of 2006''.

SEC. 2. NATIONAL INSTITUTES OF HEALTH; AWARDS FOR DEVELOPMENT AND 
              OPERATION OF RESEARCH CENTERS REGARDING ENVIRONMENTAL 
              FACTORS RELATED TO BREAST CANCER.

    Part A of title IV of the Public Health Service Act (42 U.S.C. 281 
et seq.) is amended by adding at the end the following:

``SEC. 404H. RESEARCH CENTERS REGARDING ENVIRONMENTAL FACTORS RELATED 
              TO BREAST CANCER.

    ``(a) In General.--The Secretary, acting through the Director of 
NIH, based on recommendations from the Breast Cancer and Environmental 
Research Panel established under subsection (b) (referred to in this 
section as the `Panel'), shall make grants to public or nonprofit 
private entities for the development and operation of collaborative, 
multi-institutional centers for the purpose of conducting 
multidisciplinary and multi-institutional research on environmental 
factors that may be related to the etiology of breast cancer. Each such 
center shall be known as a Breast Cancer and Environmental Research 
Center of Excellence.
    ``(b) Breast Cancer and Environmental Research Panel.--
            ``(1) Establishment.--The Secretary shall establish within 
        the National Institutes of Health a Breast Cancer and 
        Environmental Research Panel.
            ``(2) Composition.--The Panel shall be composed of--
                    ``(A) 9 members to be appointed by the Secretary, 
                of which--
                            ``(i) six members shall be appointed from 
                        among physicians and other health 
                        professionals, who--
                                    ``(I) are not officers or employees 
                                of the United States;
                                    ``(II) represent multiple 
                                disciplines, including clinical, basic, 
                                and public health sciences;
                                    ``(III) represent different 
                                geographical regions of the United 
                                States;
                                    ``(IV) are from practice settings, 
                                academia, or other research settings; 
                                and
                                    ``(V) are experienced in peer 
                                review; and
                            ``(ii) three members shall be appointed 
                        from the general public who are representatives 
                        of individuals who have had breast cancer and 
                        who represent a constituency; and
                    ``(B) such nonvoting, ex officio members as the 
                Secretary determines to be appropriate.
            ``(3) Chairperson.--The members of the Panel appointed 
        under paragraph (2)(A) shall select a chairperson from among 
        such members.
            ``(4) Meetings.--The Panel shall meet at the call of the 
        chairperson or upon the request of the Director of NIH, but in 
        no case less often than once each year.
            ``(5) Duties.--The Panel shall--
                    ``(A) develop a comprehensive strategy concerning 
                collaborative centers that would--
                            ``(i) result in innovative approaches to 
                        study unexplored or underexplored areas of the 
                        environment and breast cancer;
                            ``(ii) outline key research questions, 
                        methodologies, and knowledge gaps concerning 
                        environmental factors that may be related to 
                        the etiology of breast cancer;
                            ``(iii) outline key issues concerning 
                        environmental factors that may be related to 
                        the etiology of breast cancer; and
                            ``(iv) result in an overall strategy to 
                        address environmental factors related to breast 
                        cancer;
                    ``(B) make recommendations to the Secretary with 
                respect to the mechanisms, peer review criteria, and 
                allocations under this section;
                    ``(C) assist in the overall program evaluation; and
                    ``(D) make recommendations for the dissemination of 
                information on program process.
    ``(c) Collaboration With Community.--Each center under subsection 
(a) shall include community organizations in the geographic area served 
by the center, including those that represent women with breast cancer, 
as integral collaborators involved at all levels of the decision-making 
and research in such center.
    ``(d) Coordination of Centers; Reports.--The Director of NIH shall, 
as appropriate, provide for the coordination of information among 
centers under subsection (a) and ensure regular communication between 
such centers, and may require the periodic preparation of reports on 
the activities of the centers and the submission of the reports to the 
Director.
    ``(e) Required Consortium.--Each center under subsection (a) shall 
be formed from a consortium of cooperating institutions and community 
groups, meeting such requirements as may be prescribed by the Director 
of NIH. Each center shall require collaboration among highly 
accomplished scientists, other health professionals and advocates of 
diverse backgrounds from various areas of expertise.
    ``(f) Duration of Support.--Support of a center under subsection 
(a) may be for a period not exceeding 5 years. Such period may be 
extended for one or more additional periods not exceeding 5 years if 
the operations of such center have been reviewed by an appropriate 
technical and scientific peer review group established by the Director 
of NIH and if such group has recommended to the Director that such 
period be extended.
    ``(g) Geographic Distribution of Centers.--The Director of NIH 
shall, to the extent practicable, provide for an equitable geographical 
distribution of centers under this section.
    ``(h) Authorization of Appropriations.--For the purpose of carrying 
out this section, there is authorized to be appropriated $30,000,000 
for each of the fiscal years 2007 through 2012. Such authorization is 
in addition to any other authorization of appropriations that is 
available for such purpose.''.
                                                       Calendar No. 530

109th CONGRESS

  2d Session

                                 S. 757

                          [Report No. 109-290]

_______________________________________________________________________

                                 A BILL

To amend the Public Health Service Act to authorize the Director of the 
National Institute of Environmental Health Sciences to make grants for 
      the development and operation of research centers regarding 
  environmental factors that may be related to the etiology of breast 
                                cancer.

_______________________________________________________________________

                             July 24, 2006

                       Reported with an amendment