II 109th CONGRESS 1st Session S. 2115 IN THE SENATE OF THE UNITED STATES December 15, 2005 Ms. Stabenow (for herself, Mr. Smith, Mr. Lautenberg, Mrs. Murray, Mr. McCain, Mr. Coleman, and Mr. Dayton) introduced the following bill; which was read twice and referred to the Committee on Health, Education, Labor, and Pensions A BILL To amend the Public Health Service Act to improve provisions relating to Parkinson's disease research.

1.

Short title

This Act may be cited as the Morris K. Udall Parkinson's Disease Research Act Amendments of 2005.

2.

Morris K. Udall Parkinson's Disease Research Act of 1997

(a)

Findings

Subsection (b) of section 603 of the Morris K. Udall Parkinson's Disease Research Act of 1977 (42 U.S.C. 284f note) is amended by striking paragraph (1) and inserting the following: (1)

Finding

Congress finds that, to take full advantage of the tremendous potential for finding a cure or effective treatment, the Federal investment in Parkinson's must be expanded, as well as the coordination strengthened among the National Institutes of Health research institutes. . (b)

Public Health Service Act

Section 409B of the Public Health Service Act (42 U.S.C. 284f) is amended— (1)in subsection (b), by striking paragraph (2) and inserting the following: (2)

Conference

(A)

In general

The Director of NIH shall convene a coordinating and planning conference every 2 years with relevant institutes and non-governmental organizations to conduct a thorough investigation of all Parkinson’s research that is funded in whole or in part by the National Institutes of Health and to identify shortcomings and opportunities for more effective treatments and a cure for Parkinson’s disease. The Director shall report to Congress on the coordination among the institutes in carrying out such research. (B)

Research investment plan

(i)

In general

The results of each conference convened under subparagraph (A) shall be included in a research investment plan that provides for measurable results with the goals of better treatments and a cure for Parkinson's disease being the determining factors in the allocation of Parkinson's disease research dollars. The plan shall include an outline of the manner in which to fully utilize the Udall Center program to ensure the continuation of a particular focus on translational research, including a clinical component. (ii)

Budget and implementation strategy

The plan submitted under clause (i) shall include a budget (that includes both programmatic and dollar line items) and implementation strategy (that incorporates the use of special initiatives such as Requests for Applications, Program Announcements with set-asides or similar directed research mechanisms) together with results to be reported back to Congress. (C)

Submissions to congress

The plan under subparagraph (B) (including the budget and implementation strategy) and the expected results of plan implementation shall be submitted to Congress not later than 3 months after the conference is convened under subparagraph (A). Reports on the outcomes of the plan, including actual spending and actual results, shall be submitted to Congress on an annual basis. (D)

Funding

The Secretary shall ensure that adequate funding is available under this section to carry out the activities described in the investment plan under subparagraph (B). ; (2)in subsection (c)— (A)in paragraph (1)— (i)by striking not more than 10; and (ii)by adding at the end the following: The Director shall ensure that an additional center shall be funded under this paragraph to serve as the coordinating center to coordinate the activities conducted by each of the centers funded under this paragraph to further focus and manage the interdisciplinary efforts of such centers.; (B)in paragraph (2)(A)(ii), by striking conduct basic and clinical research and inserting in carrying out research, ensure that a significant clinical component is provided for in addition to ongoing basic research; and (C)by adding at the end the following: (5)

Review process

The Director of NIH shall establish a review process with respect to applications received for grants under paragraph (1). Such process shall provide for the evaluation of applicants in a manner that recognizes the unique aspects of the clinical, coordination, and multidisciplinary components of the applicants. ; (3)in subsection (d)— (A)by striking is authorized to establish a grant program and inserting shall award grants; and (B)by inserting before the period at the end the following: and shall be awarded in a manner consistent with the research investment plan under subsection (b)(2)(B); and (4)by striking subsection (e) and inserting the following: (e)

Report

The Director of NIH, in consultation with the Director of the Centers for Disease Control and Prevention, shall conduct an investigation, and prepare and submit to the appropriate committees of Congress a report, on the incidence of Parkinson's disease, including age, occupation, and geographic population clusters, and related environmental factors relating to such disease. (f)

Authorization of appropriations

For the purposes of carrying out this section, section 301, and this title with respect to research focused on Parkinson's disease, there are authorized to be appropriated not to exceed such sums as may be necessary for each of fiscal years 2007 through 2012. .