Defines an "HIZ" as an integrated health care delivery network that works with local employers, community leaders, and private and governmental payors in a geographic region and that: (1) provides a full spectrum of care, including inpatient, outpatient, post-acute, and preventive care, to individuals, including Medicare beneficiaries; (2) has an academic medical center that provides tertiary and quaternary care, has existing capabilities to conduct health services research, and provides clinical training for health professionals; and (3) is able to accept alternative payment structures beyond fee-for-service and per diem amounts.

Directs the Secretary to award between 10 and 25 grants of $250,000 to $1 million each to eligible entities for purposes of researching and preparing an HIZ model plan. Lists required contents of a plan, including: (1) a description of innovative models of care that improve quality and decrease costs; (2) a provider network that will provide the full spectrum of care; and (3) a target population and mechanisms to enroll such population.

Directs the Secretary to: (1) establish an HIZ demonstration project to test the effectiveness of HIZs in increasing health care provider integration, improving health care services, and reducing health care costs; and (2) select project participants from HIV model plan grant recipients. Requires the project to operate for at least three years, subject to renewal at the Secretary's discretion.

Requires an HIZ established under this Act to provide comprehensive health care services to individuals who voluntarily enroll to receive such services for multi-year periods from the HIZ.